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Antibiotics are crucial in treating infectious diseases, particularly in intensive care unit patients, but they can lead to side effects such as ototoxicity. A mechanism for this is antibiotics targeting mitochondrial components in eucaryotic cells, due to their resemblance of those in bacteria. Here we investigate how five classes of antibiotics (carbapenems, fluoroquinolones, aminoglycosides, gl

Introduction: Two large multicentre European hospital networks have estimated vaccine effectiveness (VE) against COVID-19 since 2021. Aim: We aimed to measure VE against PCR-confirmed SARS-CoV-2 in hospitalised severe acute respiratory illness (SARI) patients≥20 years, combining data from these networks during Alpha (March–June)- and Delta (June–December)dominant periods, 2021. Methods: Forty-six

Stingless bees (Meliponini) are important pollinators in tropical ecosystems and very abundant in the Bolivian Yungas region; yet little is known about their foraging behavior and floral preferences. In this study, we combined melissopalynology, pollen analysis from honey, with plant-pollinator interactions network to investigate foraging behavior and niche overlap of three rescued stingless bee s

Constans (CO), one of the key transcription factors of the zinc finger family, plays a crucial role in the photoperiodism-dependant flowering pathway. A systematic structural and functional analysis of the CO gene homologs need to be conducted in mango cultivars with contrasting bearing behaviors: ‘Amrapali’ (regular) and ‘Chausa’ (irregular). RNA-Seq leaf transcriptomes were mined for CO homologs

IntroductionEquitable access to maternal and reproductive health (MRH) services remains a major challenge in low- and lower-middle-income countries (LLMICs), including Zambia. Despite health system reforms such as the National Health Insurance Scheme (NHIS) and family planning (FP) communication strategies, disparities persist, particularly among socioeconomically disadvantaged populations. This t

Axonal injuries commonly contribute to poor functional outcomes following traumatic brain injury (TBI). To assess cerebral blood flow (CBF) and energy metabolic disturbances in a TBI model of widespread axonal injury, we exposed 105 adult mice to the central (midline) fluid percussion injury (cFPI) diffuse TBI model, or sham injury, and used 9.4 T magnetic resonance (MR) arterial spin labeling (AS

Spontaneous symmetry breaking, driven by nonadiabatic electron-nuclear coupling, can lead to geometric com plexity in molecules and solids. While structural distortion from symmetry breaking occurs in femtoseconds, the timescale to lift electronic state degeneracy has remained elusive. We use the vibrationally resolved attosecond chronoscope to capture the electronic symmetry breaking induced by t

Attosecond photoelectron interferometry, based on the measurement of photoelectron spectra generated by a two-colour field, provides access to the photoionisation dynamics of quantum systems. In general, due to the entanglement between the wave function of the emitted photoelectron and that of the parent ion, the dynamics driven by the infra-red field in the photoion can affect the properties of t

Forward osmosis (FO) and membrane distillation (MD) have emerged as promising processes for seawater desalination. One of the key factors influencing the FO process is the selection of a suitable draw solution (DS), which should exhibit high osmotic pressure and easy regeneration through a secondary process such as MD. Thermo-responsive polymers having ethylene oxide (EO) and propylene oxide (PO)

Messenger RNA (mRNA) vaccines based on lipid nanoparticles (LNPs) are stabilized with cholesterol, which is thought to be a critical LNP component because it is essential for membrane integrity and endosomal escape. Here, it is shown that cholesterol in LNPs can be replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C-type lectin receptor agonist monomycoloyl glycerol (MMG

This paper proposes a conceptual model of decision-making tying specific preferences to broader individual goals. Specifically, we consider terminal goals, representing fundamental objectives, and instrumental goals, serving as complexity-reducing intermediate steps toward achieving terminal goals and determining eventual preferences. Notably, the hierarchical goal structure allows for contextual

The invention pertains to a process for preparing a random co- poly(hydroxycarbonate) comprising reacting a 6-membered di-cyclic carbonate with a polyol, or a monohydric alcohol, via a ring-opening polymerization (ROP) by catalytic control for carbonate unit formation, in the presence of a catalyst, through a ring- opening polymerization reaction. Also, the invention pertains to a random co- poly(

Poor acoustic conditions in learning spaces have a detrimental effect on the speaker's health and constitute a risk factor for voice disorders. Previous research indicates that an acoustic refurbishment of the learning space has the potential to increase well-being and decrease voice-related health problems among teachers, but the research is scarce. In this study, we aim to investigate how differ

In the last three field seasons the Geological Survey of Denmark and Greenland (GEUS) has undertaken mapping in the south-eastern part of the Nuuk region in southern West Greenland, and here we present new zircon ages that help constrain the northern boundary of the Tasiusarsuaq terrane. The Archaean geology of the Nuuk region is commonly interpreted as a tectonic collage assembled through lateral