Sökresultat

Filtyp

Din sökning på "*" gav 530420 sökträffar

Structural Parameters determined by microCT in normal and osteoporotic human trabecular Bone are Affected Differently by image resolution

Abstract in Undetermined This study employed microCT to investigate whether image resolution affects bone structural parameters differently in healthy normal and osteoporotic trabecular bone. With increasing image voxel size, the originally detected differences between sample groups diminished. The results suggest that structural differences may not be reliably detected with clinical scanners.

Synthesis of P1 '-Functionalized Macrocyclic Transition-State Mimicking HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol

Seven novel tertiary alcohol containing linear HIV-1 protease inhibitors (PIs), decorated at the para position of the benzyl group in the P1' side with (hetero)aromatic moieties, were synthesized and biologically evaluated. To study the inhibition and antiviral activity effect of P1-P3 macro-cyclization, 14- and 15-membered macrocyclic Pis were prepared by ring-closing metathesis of the correspond

ASSOCIATION OF BTG2, CYR61, ZFP36, AND SCD GENE POLYMORPHISMS WITH GRAVES' DISEASE AND OPHTHALMOPATHY.

Background: Environmental and genetic factors predispose an individual to the development of Graves' disease (GD). In an expression study of intraorbital tissue, adipocyte-related immediate early genes (IEGs) and immunomodulatory genes were found to be overexpressed in patients with Graves' ophthalmopathy (GO). We hypothesized that genetic variations in these genes could be associated with GD and/

Effects of blood ΔR(2)* non-linearity on absolute perfusion quantification using DSC-MRI: Comparison with Xe-133 SPECT.

PURPOSE: To evaluate whether a non-linear blood ΔR(2)*-versus-concentration relationship improves quantitative cerebral blood flow (CBF) estimates obtained by dynamic susceptibility contrast (DSC) MRI in a comparison with Xe-133 SPECT CBF in healthy volunteers. MATERIAL AND METHODS: Linear as well as non-linear relationships between ΔR(2)* and contrast agent concentration in blood were applied to

Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade.

Mitotic index is an important component of histologic grade and has an etiologic role in breast tumorigenesis. Several small candidate gene studies have reported associations between variation in mitotic genes and breast cancer risk. We measured associations between 2,156 single nucleotide polymorphisms (SNPs) from 194 mitotic genes and breast cancer risk, overall and by histologic grade, in the B

Proficiency of drug susceptibility testing of Mycobacterium tuberculosis against pyrazinamide: the Swedish experience

BACKGROUND: Pyrazinamide (PZA) is a key drug in the treatment of tuberculosis (TB), including multidrug-resistant TB. Drug susceptibility testing (DST) of Mycobacterium tuberculosis against PZA is not included in the World Health Organization's yearly proficiency testing. There is an increasing need to establish quality control of PZA DST. OBJECTIVE: To evaluate the performance of PZA DST and to i

Microstructural and Swelling Properties of Ca and Na Montmorillonite: (In Situ) Observations with Cryo-TEM and SAXS

Aqueous dispersions of pure sodium and calcium smectite clays with platelet sizes on the order of a few hundred nanometers were characterized using a combination of cryo-transmission electron microscopy (cryo-TEM) and small-angle X-ray scattering (SAXS). With monovalent sodium counterions the clay is dispersed as individual platelets, as seen by cryo-TEM, that order into a nematic phase. From SAXS

Predicting fear of crime: A test of the shadow of sexual assault hypothesis

Criminologists have indicated that gender is one of the strongest predictors of fear of crime. The leading explanation for gender differences in fear of crime levels is the shadow of sexual assault hypothesis, claiming that women’s fear of sexual assault is one of the most salient factors influencing their fear of other crimes. Using a sample of 1,051 university students, this study examines the p

Mechanisms of the CO2 Insertion into (PCP) Palladium Allyl and Methyl sigma-Bonds. A Kinetic and Computational Study

The reaction of the sigma-bonded (PCP)Pd-Me complex (PCP = 2,6-bis[(di-tert-butylphosphino)methyl]phenyl) with CO2 is first-order in palladium and first-order in CO, with a rate constant k(s) = 8.9 +/- 0.8 M-1 s(-1) at 353 K. Activation parameters are Delta H double dagger = 73 7 kJ/mol and Delta S double dagger = 118 +/- 19 J/K mol. Based on this and theoretical calculations we propose an S(E)2 m

Gloss measurements of raw agricultural products using image analysis

Gloss is considered one of the most important visual attributes of many foods, which is difficult to measure objectively. In this paper, a gloss imaging system (GIS) was implemented to evaluate the suitability of four indexes for measuring gloss from intensity images in flat and curved surfaces and to analyze gloss of some fruits and vegetables. Three indexes were computed from goniometric curves:

Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic-Uremic Syndrome

Background Atypical hemolytic-uremic syndrome is a genetic, life-threatening, chronic disease of complement-mediated thrombotic microangiopathy. Plasma exchange or infusion may transiently maintain normal levels of hematologic measures but does not treat the underlying systemic disease. Methods We conducted two prospective phase 2 trials in which patients with atypical hemolytic-uremic syndrome wh

Infection dynamics of the tick-borne pathogen 'Candidatus Neoehrlichia mikurensis' and co-infections with Borrelia afzelii in bank voles in Southern Sweden.

The tick-borne bacterium 'Candidatus Neoehrlichia mikurensis' has recently been recognized as a human pathogen. Together with Borrelia afzelii, it is one of the most common pathogens found in the tick Ixodes ricinus. Here, we compared the epidemiology of 'Candidatus N. mikurensis' and B. afzelii by longitudinal sampling from May to September in one of their most abundant vertebrate hosts, the bank

Warm climate isotopic simulations: what do we learn about interglacial signals in Greenland ice cores?

Measurements of Last Interglacial stable water isotopes in ice cores show that central Greenland delta O-18 increased by at least 3 parts per thousand compared to present day. Attempting to quantify the Greenland interglacial temperature change from these ice core measurements rests on our ability to interpret the stable water isotope content of Greenland snow. Current orbitally driven interglacia

Methods for individualising factor VIII dosing in prophylaxis

Haemophilia A is a sex-linked disorder characterised chiefly by recurrent, spontaneous joint and muscle bleedings resulting from deficiency of factor VIII (FVIII). Recurrent joint bleeds result in haemophilic arthropathy. Unless treated with factor replacement therapy, many patients with severe haemophilia become disabled. The first clinical evidence favouring prophylaxis originated from the studi

Can One Distinguish Quantum Trees From The Boundary?

Schrodinger operators on metric trees are considered. It is proven that for certain matching conditions the Titchmarsh-Weyl matrix function does not determine the underlying metric tree; i.e. there exist quantum trees with equal Titchmarsh-Weyl functions. The constructed trees form one-parameter families of isospectral and isoscattering graphs.