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Design of atto-vial based recombinant antibody arrays combined with a planar wave-guide detection system

Antibody microarray is a rapidly emerging, powerful approach with great promise within high-throughput proteomics. However, before a truly proteome-wide analysis can be performed, the antibody array format needs to be miniaturized even further in order to enable ultradense arrays to be fabricated. To this end, we have designed and generated proof-of-concept for the first generation of an atto-vial

A three-dimensional paradigm of fiber orientation in timber

Knowledge of the three-dimensional orthogonal directions of wood material at any position within a tree is necessary for the understanding of strength reducing effects of knots and essential for the continuation of research in areas which relate small clear wood specimen behavior to the behavior of full size structural timber. A complete three-dimensional paradigm describing the geometry of knots

Spectroscopy at N=Z with EUROBALL III

A complete study of the nuclear structure by means of gamma spectroscopy requires, in addition to the high resolution gamma measurement and accurate DCO's or angular distributions, the information concerning the Electric or Magnetic character of the transition. This information for transitions in nuclei far from stability valley is now reachable in the new generation of Ge-arrays based in composit

Detection of occult tumour cells in lymph nodes of colorectal cancer patients using real-time quantitative RT-PCR for CEA and CK20 mRNAS

The purpose of our study was to develop specific, sensitive, objective assays for early detection of disseminated tumour cells in patients with colorectal cancer (CRC). Carcinoembryonic antigen (CEA) and cytokeratin 20 (CK20) were chosen as markers because they are selectively expressed in epithelial cells with maintained expression in CRC. Real-time quantitative RT-PCR assays with RNA copy standa

CC chemokine ligand 20 partially controls adhesion of naive B cells to activated endothelial cells under shear stress

Chemokines are thought to control lymphocyte recruitment to the inflamed endothelium. To dissect chemokine-mediated adhesion, binding of ex vivo isolated splenocytes to tumor necrosis factor (TNF)-activated endothelial cells was analyzed under shear stress. We observed specific adhesion of naive follicular B cells, which could be blocked by pertussis toxin. This indicated a G protein-mediated bind

Fluorescence spectra provide information on the depth of fluorescent lesions in tissue

The fluorescence spectrum measured from a fluorophore in tissue is affected by the absorption and scattering properties of the tissue, as well as by the measurement geometry. We analyze this effect with Monte Carlo simulations and by measurements on phantoms. The spectral changes can be used to estimate the depth of a fluorescent lesion embedded in the tissue by measurement of the fluorescence sig

Scanning tunneling microscopy study of metal-free phthalocyanine monolayer structures on graphite

Low temperature scanning tunneling microscopy (STM) studies of metal-free phthalocyanine (H2Pc) adsorbed on highly oriented pyrolytic graphite (HOPG) have shown ordered arrangement of molecules for low coverages up to 1 ML. Evaporation of H2Pc onto HOPG and annealing of the sample to 670 K result in a densely packed structure of the molecules. Arrangements of submonolayer, monolayer, and monolayer

Biofilm photobioreactors for the treatment of industrial wastewaters.

A flat plate and a tubular packed-bed photobioreactor with an algal-bacterial biofilm attached onto Poraver((R)) beads carriers, a flat plate and a tubular photobioreactor with the biofilm attached onto the reactor walls, and an algal-turf reactor were compared in terms of BOD removal efficiencies, elimination capacities, and stability. A control column photobioreactor with suspended algal-bacteri

An Efficient Numerical Algorithm for Cracks Partly in Frictionless Contact

An algorithm for a loaded crack partly in frictionless contact is presented. The problem is nonlinear in the sense that the equations of linear elasticity are supplemented by certain contact inequalities. The location of a priori unknown contact zones and the solutions to the field equations must be determined simultaneously. The algorithm is based on a rapidly converging sequence of relaxed Fredh

Probing the nature of the G1 clump stellar overdensity in the outskirts of M31

We present deep Hubble Space Telescope ACS observations of the G1 clump, a distinct stellar overdensity lying at similar to 30 kpc along the southwestern major axis of M31, close to the G1 globular cluster ( from the work of Ferguson and coworkers). Our well-populated color-magnitude diagram reaches similar to 7 mag below the red giant branch tip with 90% completeness, and allows the detection of

Species-specific effects of vascular plants on carbon turnover and methane emissions from wetlands

Species composition affects the carbon turnover and the formation and emission of the greenhouse gas methane (CH4) in wetlands. Here we investigate the individual effects of vascular plant species on the carbon cycling in a wetland ecosystem. We used a novel combination of laboratory methods and controlled environment facilities and studied three different vascular plant species (Eriophorum vagina

School marks for Swedish children whose mothers had diabetes during pregnancy: a population-based study

Aims/hypothesis To study, at a population level, school performance when leaving compulsory school of Swedish children whose mothers had diabetes during pregnancy compared with a reference population. Mehtohds We linked the Swedish Medical Birth Register with the Swedish School Mark Register, which contains school marks for all children in Sweden when leaving compulsory school. A total of 6,397 ch

Loop-shaping design of PID controllers with constant Ti/Td ratio

This paper presents new tuning rules for PIDcontrollers based on loop shaping. Previous research has shownthat maximization of the integral gain subject to constraints on the maximumsensitivity is an efficient design method for PI controllers, but thatadditional constraints are needed for design of PID controllers. Inthis paper, an additional constraint is obtained by restricting theratio between

Protein reconstitution and three-dimensional domain swapping: Benefits and constraints of covalency

The phenomena of protein reconstitution and three-dimensional domain swapping reveal that highly similar structures can be obtained whether a protein is comprised of one or more polypeptide chains. In this review, we use protein reconstitution as a lens through which to examine the range of protein tolerance to chain interruptions and the roles of the primary structure in related features of prote

Negative neurofilament light and tau immunostaining in frontotemporal dementia

We investigated the immunohistochemical stainability of phosphorylated tau and the light (NFL), intermediate (NFM), and heavy (NFH) neurofilament proteins in postmortem brain tissue from 8 patients with frontotemporal dementia (FTD), for comparison with 6 patients with Alzheimer's disease (AD), and 6 normal controls. In the FTD group, the neuropathological diagnosis was pure frontal-lobe degenerat