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Origin of suppressed demixing in casein/xanthan mixtures

We explore the properties of casein/xanthan mixtures for xanthan concentrations beyond those inducing phase separation. Previous work has successfully described the onset of demixing by depletion theory in the protein limit, where the xanthan polysaccharides, the polymers, are larger than the caseins from skim milk powder, the colloids (S. Bhat et al., J. Phys.: Condens. Matter, 2006, L339). We no

A survey of biting midges of the genus Culicoides Latreille, 1809 (Diptera: Ceratopogonidae) in NE Bulgaria, with respect to transmission of avian haemosporidians

This study presents data from a molecular survey of the species of the genus Culicoides from the region of Kalimok Field Station (NE Bulgaria) and haemosporidian parasites occurring in them in order to investigate the host-parasite specificity of haemosporidians to their dipteran vectors. The identification of Culicoides spp. was carried out by morphological and molecular-genetic methods. We colle

Comparison of two strategies to reduce ventricular pacing in pacemaker patients

Background: Managed Ventricular Pacing (MVP) and Search AV+ (SAV+) are two pacing algorithms designed to reduce ventricular pacing, MVP promotes conduction by operating in AAI/R mode with backup ventricular pacing during atrioventricular block (AVB). SAV+ operates in DDD/R mode with a nominal AV extension of 290 ms during atrial sensing and 320 ms during atrial pacing. The reduction in ventricular

System Identification in GSM/EDGE Receivers Using a Multi-Model Approach

Model order selection is an important element in system identification. It is well known that common model order selection methods such as Akaike’s information criterion (AIC) and Bayesian’s information criterion (BIC) neglect relevant information that is available in models of order different from the one chosen. In this paper the model order selection problem for receivers similar to those found

Characterization of human dopaminergic neurons in the developing mesencephalon and upon differentiation of stem cells- for replacement therapy in Parkinson´s disease

Popular Abstract in Swedish Hjärnan är ett av människans viktigaste organ och är det centra som styr våra känslor, minnen och sociala färdigheter. Hjärnan är också det organ som signalerar till musklerna i kroppen att utföra rörelser. När en person drabbas av Parkinsons sjukdom minskar signaleringen till musklerna, vilket medför att det blir svårt att röra sig och stelhet uppstår. Sjukdomen beror Cell-replacement therapy is a promising approach for treating patients with Parkinson ́s disease (PD). For this purpose, there is a need for developing a protocol that can generate high numbers of human transplantable mesencephalic dopaminer- gic (mesDA) neurons. For decades, studies have therefore been made in mouse and other model organisms in order to elucidate key-factors that can be used for

Some open questions in TDDFT: Clues from lattice models and Kadanoff-Baym dynamics

Two aspects of TDDFT, the linear response approach and the adiabatic local density approximation, are examined from the perspective of lattice models. To this end, we review the DFT formulations on the lattice and give a concise presentation of the time-dependent Kadanoff-Baym equations, used to asses the limitations of the adiabatic approximation in TDDFT. We present results for the density respo

Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal beta-cell lines

Insulin secretion from pancreatic beta-cells is controlled by complex metabolic and energetic changes provoked by exposure to metabolic fuels. Perturbations in these processes lead to impaired insulin secretion, the ultimate cause of T2D (Type 2 diabetes). To increase our understanding of stimulus secretion coupling and metabolic processes potentially involved in the pathogenesis of T2D, a compreh

Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome

It is increasingly clear that asthma is a complex disease made up of number of disease variants with different underlying pathophysiologies. Limited knowledge of the mechanisms of these disease subgroups is possibly the greatest obstacle in understanding the causes of asthma and improving treatment and can explain the failure to identify consistent genetic and environmental correlations to asthma.

Elevated tolerance to aneuploidy in cancer cells: estimating the fitness effects of chromosome number alterations by in silico modelling of somatic genome evolution.

An unbalanced chromosome number (aneuploidy) is present in most malignant tumours and has been attributed to mitotic mis-segregation of chromosomes. However, recent studies have shown a relatively high rate of chromosomal mis-segregation also in non-neoplastic human cells, while the frequency of aneuploid cells remains low throughout life in most normal tissues. This implies that newly formed aneu

White-dwarf kicks and implications for barium stars

The formation mechanism of the barium stars is thought to be well understood. Barium-rich material, lost in a stellar wind from a thermally-pulsing asymptotic-giant branch star in a binary system, is accreted by its companion main-sequence star. Now, many millions of years later, the primary is an unseen white dwarf and the secondary has itself evolved into a giant which displays absorption lines

Prognostic and Treatment Predictive Markers Associated with Cyclin D1 Gene Amplification and Epithelial-Mesenchymal Transition in Breast Cancer

Endocrine resistant breast cancer is a major therapeutical challenge and accurate selection of patients susceptible to certain types of anti-hormonal treatment strategies is pivotal. Discovery of novel biomarkers potentially predicting treatment response as well as the clinical course of breast cancer is essential to effectively improve therapies and diagnosis. The main goal of this thesis was to

Abundances in bulge stars from high-resolution, near-IR spectra I. The CNO elements observed during the science verification of CRIRES at VLT

Context. The formation and evolution of the Milky Way bulge is not yet well understood and its classification is ambiguous. Constraints can, however, be obtained by studying the abundances of key elements in bulge stars. Aims. The aim of this study is to determine the chemical evolution of C, N, O, and a few other elements in stars in the Galactic bulge, and to discuss the sensitivities of the der

Use of Lung Weight as Biomarker for Assessment of Lung Toxicity in Rat Inhalation Studies

Subacute inhalation study (1 week or 2 weeks) is an important process for screening out inhaled compounds causing lung irritation. To investigate whether the lung weight can be used as an indicator for acute lung injury, we have analyzed retrospectively the lung weight data from 30 studies in rats exposed to dry powder inhalation. The lung weight change was correlated with lung histopathology in t

On squaring triangles - Structural motifs in Cu-In-Sb compounds

Two new ternary Cu-In-Sb compounds Cu7In2.5Sb0.5 and Cu2In0.75Sb0.25 are presented. Both compounds are Ni2In type superstructures with vacancies in the pseudohexagonal network. Additionally, the pseudocubic nature of the compounds and Ni2In type (super)structures, in general, is discussed. Remarkably, a large number of pseudo-five-fold and pseudo-three-fold axes contribute to generate a pseudocubi

Patterns of survival and causes of death following a diagnosis of monoclonal gammopathy of undetermined significance: a population-based study

Background There are limited data on survival patterns among patients with monoclonal gammopathy of undetermined significance. Design and Methods We compared the survival of 4,259 patients with monoclonal gammopathy of undetermined significance, collected from hematology outpatient units in Sweden, with the survival of the general population by computing relative survival ratios. We also compared