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Assessing the capabilites to manage risks in energy systems–analytical perspectives and frameworks with a starting point in Swedish experiences

In this study we conceptualise how a capability approach could be used for analysing the conditions for preserving security of energy supply. We derive a concept, ‘energy system capability’, to describe how well the system is designed for this purpose. Based on a socio-technical systems perspective, we suggest that this capability is composed of five categories of ‘building blocks’: technical stru

Binding and inhibition of spermidine synthase from Plasmodium falciparum and implications for in vitro inhibitor testing

The aminopropyltransferase spermidine synthase (SpdS) is a promising drug target in cancer and in protozoan diseases including malaria. Plasmodium falciparum SpdS (PfSpdS) transfers the aminopropyl group of decarboxylated S-adenosylmethionine (dcAdoMet) to putrescine or to spermidine to form spermidine or spermine, respectively. In an effort to understand why efficient inhibitors of PfSpdS have be

The influence of magnetic steps on bulk superconductivity

We study the distribution of bulk superconductivity in presence of an applied magnetic field, supposed to be a step function, modeled by the Ginzburg-Landau theory. Our results are valid for the minimizers of the twodimensional Ginzburg-Landau functional with a large Ginzburg-Landau parameter and with an applied magnetic field of intensity comparable with the Ginzburg-Landau parameter.

Thermal enhancement by using grooves and ribs combined with delta-winglet vortex generator in a solar receiver heat exchanger

A good heat transfer performance with moderate pressure drop penalty, as well as a high mixing effect contributes to the increase of a solar receiver thermal efficiency. In this study, delta-winglet vortex generators (DWVGs), and the combination of DWVGs and obstacles are numerically studied to reveal the effects on a solar receiver heat exchanger and the heat transfer, friction factor and mixing.

Paradoxical role of hmgb1 in pancreatic cancer : Tumor suppressor or tumor promoter?

Pancreatic cancer has a dismal prognosis and there is an increasing and unmet need to identify better diagnostic and therapeutic targets in order to ameliorate the course of the disease. HMGB1, a nuclear DNA-binding protein that acts as a transcription factor, is currently in the limelight. HMGB1 exhibits a dual role in pancreatic cancer; when intracellular, it acts as an anti-tumor protein stabil

α-Synuclein is a Novel Microtubule Dynamase

α-Synuclein is a presynaptic protein associated to Parkinson's disease, which is unstructured when free in the cytoplasm and adopts α helical conformation when bound to vesicles. After decades of intense studies, α-Synuclein physiology is still difficult to clear up due to its interaction with multiple partners and its involvement in a pletora of neuronal functions. Here, we looked at the remarkab

Manufacturing backshoring : a systematic literature review

The purpose of this research is to review and analyze in a systematic manner the current research published in peer-reviewed international scientific journals on the backshoring of manufacturing. We identify 20 articles published from 2009 to early 2016. We classify and discuss the literature according to publication year, research methodology, industry type, and firm size. Using content analysis,

Variable residence time-based model for BOD removal in free-water surface wetlands

Constructed wetlands have been increasingly used for treatment of secondary wastewater containing various contaminants. This paper presents a Variable Residence Time (VART)-based model, called VART-BOD model, for simulation of BOD removal processes in constructed wetlands with free water surface (FWS). Mathematically, the VART-BOD model describes a free water surface wetland with three vertical la

Update on hereditary colorectal cancer

In the past two decades, significant advances have been made in our understanding of colorectal (CRC) tumors with DNA mismatch (MMR) repair deficiency. The knowledge from molecular and genetic alterations in a variety of clinical conditions has refined the disease terminology and classification. Hereditary non-polyposis colorectal cancer (HNPCC) encompasses a spectrum of conditions that have signi

GaAsP Nanowires Grown by Aerotaxy

We have grown GaAsP nanowires with high optical and structural quality by Aerotaxy, a new continuous gas phase mass production process to grow III-V semiconductor based nanowires. By varying the PH3/AsH3 ratio and growth temperature, size selected GaAs1-xPx nanowires (80 nm diameter) with pure zinc-blende structure and with direct band gap energies ranging from 1.42 to 1.90 eV (at 300 K), (i.e., 0

Long-term oxygen therapy 24 vs 15 h/day and mortality in chronic obstructive pulmonary disease

Long-term oxygen therapy (LTOT) ≥ 15 h/day improves survival in hypoxemic chronic obstructive pulmonary disease (COPD). LTOT 24 h/day is often recommended but may pose an unnecessary burden with no clear survival benefit compared with LTOT 15 h/day. The aim was to test the hypothesis that LTOT 24 h/day decreases all-cause, respiratory, and cardiovascular mortality compared to LTOT 15 h/day in hypo

Improving the mix of institutional and community care for older people with dementia : an application of the balance of care approach in eight European countries

Objectives: To examine whether the mix of community and institutional long-term care (ILTC) for people with dementia (PwD) in Europe could be improved; assess the economic consequences of providing alternative services for particular groups of ILTC entrants and explore the transnational application of the ‘Balance of Care’ (BoC) approach. Method: A BoC study was undertaken in Estonia, Finland, Fra

Computational characterization of competing energy and electron transfer states in bimetallic donor-acceptor systems for photocatalytic conversion

The rapidly growing interest in photocatalytic systems for direct solar fuel production such as hydrogen generation from water splitting is grounded in the unique opportunity to achieve charge separation in molecular systems provided by electron transfer processes. In general, both photoinduced and catalytic processes involve complicated dynamics that depend on both structural and electronic effec

Bumblebees perform well-controlled landings in dim light

To make a smooth touchdown when landing, an insect must be able to reliably control its approach speed as well as its body and leg position—behaviors that are thought to be regulated primarily by visual information. Bumblebees forage and land under a broad range of light intensities and while their behavior during the final moments of landing has been described in detail in bright light, little is

Enhancing the productivity of the bi-enzymatic convergent cascade for ɛ-caprolactone synthesis through design of experiments and a biphasic system

A two-step Design of Experiments (DoE) strategy followed by a two-liquid-phase system (2LPS) was applied to enhance the ɛ-caprolactone yield in the cyclohexanone monooxygenase (CHMO)-alcohol dehydrogenase (ADH) convergent cascade system. The key reaction parameters were identified and optimized for the determination of an optimal operational window for the aqueous media. In the 2LPS system, high p

Translocation of 40 nm diameter nanowires through the intestinal epithelium of Daphnia magna

Nanowires (NWs) have unique electrical and optical properties of value for many applications including lighting, sensing, and energy harnessing. Consumer products containing NWs increase the risk of NWs being released in the environment, especially into aquatic ecosystems through sewage systems. Daphnia magna is a common, cosmopolitan freshwater organism sensitive to toxicity tests and represents

NURBS based form finding of efficient shapes for shells

This paper presents ongoing research on using non-uniform rational b-splines(NURBS) based isogeometric analysis for form finding of efficient shapes for shells. The form finding is made using dynamic relaxation together with NURBS based membrane elements. The method is employed directly to design geometry, without the need for any further discretization. The method is implemented in two plug-ins f

Nano electrospray gas-phase electrophoretic mobility molecular analysis (nES GEMMA) of liposomes : Applicability of the technique for nano vesicle batch control

Liposomes are biodegradable nanoparticle vesicles consisting of a lipid bilayer encapsulating an aqueous core. Entrapped cargo material is shielded from the extra-vesicular medium and sustained release of encapsulated material can be achieved. However, application of liposomes as nano-carriers demands their characterization concerning size and size distribution, particle-number concentration, occu

IGF-I in the clinics : Use in retinopathy of prematurity

Retinopathy of prematurity is a potentially blinding disease, which is associated with low neonatal IGF-I serum concentrations and poor growth. In severe cases impaired retinal vessel growth is followed by pathologic neovascularization, which may lead to retinal detachment. IGF-I may promote growth even in catabolic states. Treating preterm infants with recombinant human (rh) IGF-I to concentratio