The bioassay-guided isolation of compounds from the aerial parts of Isodon lophanthoides (IL) resulted in the identification of five compounds (1–5). The chemical structures of 1–5 were determined through spectral analyses and compared to those identified in the literature to be 4-hydroxybenzoic acid (1), protocatechuic acid (2), rosmarinic acid (3), coetsoidin B (4), and coetsoidin A (5). Compoun

Exposure to infectious diseases in early life has been linked to increased mortality risk in later life in high-disease settings, such as eighteenth- and nineteenth-century Europe. Less is known about the long-term effects of early-life disease exposure in milder disease environments. This study estimates heterogeneous effects from disease exposure in infancy on later-life mortality in twentieth-c

Lipid-based nanoparticles (LNPs), ranging from nanovesicles to non-lamellar assemblies, have gained significant attention in recent years, as versatile carriers for delivering drugs, vaccines, and nutrients. Small-angle scattering methods, employing X-rays (SAXS) or neutrons (SANS), represent unique tools to unveil structure, dynamics, and interactions of such particles on different length scales,

The ArmazoNes high Dispersion Echelle Spectrograph (ANDES) is the optical and near-infrared high-resolution echelle spectrograph envisioned for the Extremely Large Telescope (ELT). We present a selection of science cases, supported by new calculations and simulations, where ANDES could enable major advances in the fields of stars and stellar populations. We focus on three key areas, including the

Background. The 2023 Duke-International Society of Cardiovascular Infectious Diseases (ISCVID) criteria for infective endocarditis (IE) were introduced to improve classification of IE for research and clinical purposes. External validation studies are required. Methods. We studied consecutive patients with suspected IE referred to the IE team of Amsterdam University Medical Center (from October 20

In this paper we investigate the ways in which a university, taking on the scale of a city of its own, affords meetings for researchers and teachers between disciplines. How does the continuous transformation and expansion of the university’s physical environment affect the everyday lives and serendipitous encounters of the researchers active within it? The aim of the paper is to develop a concept

Importance: Women with adverse pregnancy outcomes, such as preterm delivery or preeclampsia, have higher future risks of cardiometabolic disorders; however, little is known about their long-term mortality risks. A better understanding of such risks is needed to facilitate early identification of high-risk women and preventive actions. Objective: To determine long-term mortality risks associated wi

In the context of climate change and increasing water scarcity, adopting water demand-side management (DSM) policies has become necessary. This study advocates for utilizing agent-based modelling (ABM) as a robust simulation tool to assess the impact of nonprice (nudges) and price (changes in increasing block tariff) measures on urban water use. Overcoming challenges posed by insufficient high-qua

BakgrundVaccination är en av de viktigaste folkhälsoinsatserna för att rädda liv och hindra spridning av smittsamma sjukdomar. Tack vare vaccinationer har miljontals liv räddats världen över. Men det räcker inte att säkra och effektiva vaccin tas fram och tillgängliggörs. En förutsättning för framgångarna är att individer accepterar att bli vaccinerade. Under senare tid har forskningsområdet om vaThe vaccination coverage in Sweden's National Immunization Program (NIP) has been highand stable for decades. Although the coverage is high, few studies have assessed parental vaccineacceptance in Sweden. This doctoral thesis aimed to provide an in-depth understanding of currentparental vaccine acceptance, focusing particularly on Human papillomavirus (HPV) and measles, mumps and rubella (MMR) vac

Electroactive polymers (EAPs) deform when subject to an electric field, which is generated by two or more electrodes. To ensure proper function of the EAP, these electrodes are connected to a source and they are therefore required to be continuous such that no isolated islands exist. Increasing an EAP’s performance using topology optimization while ensuring electrode connectivity is the goal of th

Alla dör, men våra upplevelser av livets slut ser olika ut beroende på hur vårt liv och våra relationer sett ut. Denna avhandling undersöker hur genus, ålder och relationer påverkar människors erfarenheter och möjligheter under livets slutskede. I en tid då såväl hälso- och sjukvårdssystemen som informellt vård- och omsorgsgivande är satta under press är det extra viktigt att utveckla kunskap om hThe way that we die and care for the dying today is changing, related to extended life expectancy, neoliberalization, as well as shifting caring roles in relation to gender. In a time of “care crisis”, both formal and informal care resources are under duress, making the question of how to provide “a good death” complex and contested in new ways. Scholars in public health have posited a health prom

Corrosion results in large costs and environmental impact but can be controlled by thin oxide films that passivate the metal surfaces and hinder further oxidation or dissolution in an aqueous environment. The structure, chemistry, and thickness of these oxide films play a significant role in determining their anti-corrosion properties and the early-stage oxidation dynamics affect the properties of

Purpose: This study aims to investigate the adoption of the United Nations’ Sustainable Development Goals (SDGs) as the new performance perspective in cities. It also aims to understand how accounting for SDGs begins in city administrations by following Power’s (2015) fourfold development schema composed of policy object formation, object elaboration, activity orchestration and practice stabilizat

Purpose: This study addresses the implications of smart city development paths (techno-centric and human-centric) by investigating the evolution of a city strategy, focusing on how different actors in a dialogue centred on strategic planning documents for Saint Petersburg, Russia, visualised the smart city and then made it calculable. Design/methodology/approach: The authors conducted a case study

Koldioxidinfångning (CDR) har blivit en central komponent i de scenarier för klimatmitigation som IPCC har utvärderat. Dessa scenarier bygger på storskalig användning av bioenergi med avskiljning och lagring av koldioxid (BECCS) och skogsplantering för att hålla den globala medeltemperaturen under 2°C, trots betydande problem gällande genomförbarhet, skalbarhet och oönskade effekter. I den här avhCarbon dioxide removal (CDR) has become a central component in the climate change mitigation scenarios assessed by the IPCC. These scenarios rely on the large-scale deployment of Bioenergy with Carbon Capture and Storage (BECCS) and Afforestation to keep global average temperatures below 2°C of warming, despite substantial concerns about their feasibility, scalability, and unwanted impacts. In thi

The concept of smart city has been studied in a variety of forms and contexts. While previous studies highlight the extensive use of indicators of smartness, another stream of literature advocates the role of citizens in city transformations. In this viewpoint, we call for an extension of this dichotomous understanding and highlight the cross-sectoral collaborative nature of smart city; we also dr

This paper presents initial research within a broader discourse about smart cities. Despite the existence of various discussions about the concept many questions are still opened. We bridge the gap by investigating the role of local governments and their initiatives to integrate new technologies in a city context. The study aims to investigate the adoption of technological innovation in smart citi

Postural tachycardia syndrome (POTS) is a chronic autonomic disorder characterized by excessive heart rate elevation upon standing or head-up tilt, in the absence of orthostatic hypotension. This debilitating condition affects primarily young to middle-aged individuals, particularly women, and substantially influences quality of life. The main presenting symptoms are lightheadedness, palpitations,