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Loss of TGFβ Receptor Type 2 Expression Impairs Estrogen Response and Confers Tamoxifen Resistance.

One third of the patients with estrogen receptor alpha (ER alpha)-positive breast cancer who are treated with the antiestrogen tamoxifen will either not respond to initial therapy or will develop drug resistance. Endocrine response involves crosstalk between ER alpha and TGF beta signaling, such that tamoxifen non-responsiveness or resistance in breast cancer might involve aberrant TGF beta signal

Developing a thermophilic hydrogen-producing co-culture for efficient utilization of mixed sugars

Previous studies on the extreme thermophile Caldicellulosiruptor saccharolyticus revealed that the organism produces high yields of hydrogen on glucose and xylose, the major components of lignocellulosic hydrolysates. Preliminary experiments on mixed sugar substrates, however, indicated that xylose was preferred over glucose. The sugar preference of some other extreme thermophiles, including Caldi

Rivet user manual

This is the manual and user guide for the Rivet system for the validation and tuning of Monte Carlo event generators. As well as the core Rivet library, this manual describes the usage of the rivet program and the AGILe generator interface library. The depth and level of description is chosen for users of the system, starting with the basics of using validation code written by others, and then cov

A New Pedagogical Approach for Integrating Social Work Students and Service Users

This paper analyses recent experiences at the School of Social Work, Lund University, the first in Sweden to use an innovative pedagogical approach for integrating social service users with social work students in the classroom (an EU-funded project). The concept of gift exchange was used to make sense of the approach. Gift exchange is based on the norm of reciprocity and the principles of gift ec

Fogelström och hans stad

Recension av Karl-Olof Andersson, Per-Anders Fogelström – ett liv för litteraturen, freden och miljön.

Operation and performance of the ATLAS semiconductor tracker

The semiconductor tracker is a silicon microstrip detector forming part of the inner tracking system of the ATLAS experiment at the LHC. The operation and performance of the semiconductor tracker during the first years of LHC running are described. More than 99% of the detector modules were operational during this period, with an average intrinsic hit efficiency of (99.74 +/- 0.04)%. The evolution

The stability of alexithymia during work in a high-stress environment: A prospective study of Swedish peacekeepers serving in Kosovo.

Larsson, M. R., Bäckström, M., Michel, P.-O. & Lundh, L.-G. (2010). The stability of alexithymia during work in a high-stress environment: A prospective study of Swedish peacekeepers serving in Kosovo. Scandinavian Journal of Psychology. We applied a prospective design to reinvestigate the issue whether the sub-domains of alexithymia could be considered stable traits or distress-related states

South Swedish bog pines as indicators of Mid-Holocene climate variability

Dendroclimatic investigations of subfossil Scots pine (Pinus sylvestris) from two raised bogs in southern Sweden yielded a continuous floating 1492-year long tree-ring record. By cross-dating with bog-pine chronologies from Lower Saxony, Germany, the South Swedish record was assigned an absolute age of 5219-3728 BC. The cross-match between ring-width chronologies from these two regions, separated

STrengthening the Reporting of OBservational studies in Epidemiology - Molecular Epidemiology (STROBE-ME): An extension of the STROBE statement

Advances in laboratory techniques have led to a rapidly increasing use of biomarkers in epidemiological studies. Biomarkers of internal dose, early biological change, susceptibility and clinical outcomes are used as proxies for investigating interactions between external and / or endogenous agents and body components or processes. The need for improved reporting of scientific research led to influ

Scattering by inhomogeneities in parallel plate waveguides

Electromagnetic scattering by a bounded object located inside a parallel plate waveguide is the subject of this paper. The exciting field in the waveguide is either an arbitrary source located at a finite distance from the obstacle or a plane wave generated in the far zone. The analytic treatment of the problem relies on an extension of the null field approach or Tmatrix method.

The Undercut Criterion of Pinion Shaper Cutters: And an Improvement by Modifying the Basic Rack Profile

The fillet of the gear tooth is highly stressed in operation; so for heavily loaded gears, the fillet geometry must be controlled. The manufacturer's task is to, within acceptable tolerances, produce the gear to the designer's specifications regardless of the manufacturing method. Most often gear cutting tools are used that work under generating conditions. The tool will form the gear tooth; so to

Teenagers want to be told when a parent's death is near: A nationwide study of cancer-bereaved youths' opinions and experiences

Background. We aimed to investigate cancer-bereaved youths' opinions and experiences of being told about a parent's imminent death from cancer and of barriers to this communication. Material and methods. This nationwide population-based survey included 622/851 (73%) youths (aged 18 -26) who at age 13-16, 6-9 years earlier had lost a parent to cancer. Results. In total 595 of 610 (98%) of the parti

Heat integration of a fermentation-based hydrogen plant connected with sugar factory

The paper is concerned with heat integration of a conceptual hydrogen plant connected with a sugar factory. The sugar factory serves as a source of sucrose-containing thick juice for the hydrogen plant, where this feedstock is processed to hydrogen. Moreover, this connection gives an opportunity to utilize waste heat from the sugar factory. Hydrogen is produced by two-stage fermentation, that is,

Diagnostic Methods

Non-invasive vascular studies can provide crucial information on the presence, location, and severity of critical limb ischaemia (CLI), as well as the initial assessment or treatment planning. Ankle-brachial index with Doppler ultrasound, despite limitations in diabetic and end-stage renal failure patients, is the first-line evaluation of CLI. In this group of patients, toe-brachial index measurem

Can Skylarks Alauda arvensis discriminate a parasite nestling? Possible case of nestling Cuckoo Cuculus canorus ejection by its host parents

The Common Cuckoo Cuculus canorus is an obligate brood parasite and many studies have dealt with egg rejection by host species. However, evidence for ejection of Cuckoo nestlings by host parents has not been reported. Here we describe an observation of a Skylark Alauda arvensis pair that probably ejected a young Cuckoo and subsequently raised their own offspring. This was the only case we detected