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Mevalonate inhibits acid sphingomyelinase activity, increases sphingomyelin levels and inhibits cell proliferation of HepG2 and Caco-2 cells.

Sphingomyelin (SM) and cholesterol are two types of lipid closely related biophysically. Treating the cells with exogenous sphingomyelinase (SMase) induces trafficking of cholesterol from membrane to intracellular pools and inhibition of cholesterol synthesis. In the present work, we address a question whether increased cholesterol synthesis affects hydrolysis of SM by endogenous SMases.

Evaluation of particle measures relevant for powder bed porosity-A study of spray dried dairy powders

The formation of lumps during large scale wetting of spray dried powders is a common problem in the industry. The result is a large energy demand if an efficient mixing is to be achieved at the industrial scale. If more knowledge regarding the phenomena governing lump formation is obtained, the unit operation could be optimized and made more efficient. As a part of increasing the understanding of

Photocathode operation of a thermionic RF gun

The thermionic RF gun using a BaO cathode at the MAX-lab linac injector has been successfully commissioned for additional operation as a photocathode gun. By retaining the BaO cathode, lowering the temperature below thermal emission and illuminating it with a UV (263 nm) 9 ps laser pulse a reduced emittance and enhanced emission control has been achieved. Measurements show a normalised emittance o

Anti-Nazi 'superstar' or 'racist'? Sture Bolin's politics: continuity, change, and later evaluations

In the spring of 1945, survivors of the Nazi concentration camps arrived in southern Sweden. A project was launched to collect eye-witness accounts of their experiences and document them for posterity. The scholar in charge of this project was Sture Bolin, professor of history at Lund University After his death Erik Lonnroth hailed him as a 'world-famous' historian. By the turn of the century he w

Fog-basking behaviour and water collection efficiency in Namib Desert Darkling beetles

Background: In the Namib Desert fog represents an alternative water source. This is utilised by Darkling beetles (Tenebrionidae) that employ different strategies for obtaining the fog water. Some dig trenches in the sand, while others use their own bodies as fog collectors assuming a characteristic fog-basking stance. Two beetle species from the genus Onymacris have been observed to fog-bask on th

Thermohaline Mixing And Its Role In The Evolution Of Carbon And Nitrogen Abundances In Globular Cluster Red Giants: The Test Case Of Messier 3

We review the observational evidence for extra mixing in stars on the red giant branch (RGB) and discuss why thermohaline mixing is a strong candidate mechanism. We recall the simple phenomenological description of thermohaline mixing and aspects of mixing in stars in general. We use observations of M3 to constrain the form of the thermohaline diffusion coefficient and any associated free paramete

A mobile multi-depth borehole sensor set-up to study the surface-to-base seismic transfer functions

The best method to evaluate the seismic site response is by means of borehole vertical arrays that use earthquake records from different depths. In this paper we introduce the implementation of a single borehole sensor system (synchronized to a sensor on the surface) that is fixed at variable depths within a single well. This system is used for recording small amplitude earthquake signals at varia

Floorball-related eye injuries: The impact of protective eyewear.

Several previous studies have shown that floorball belongs to a high-risk group of sports in terms of eye injuries. Protective eyewear is available, but the extent of its use and impact on eye injuries are unknown. The purpose of this study was to investigate the current incidence of eye injuries caused by floorball and to compare it with the present use of protective eyewear. Medical records were

Fotblomflugor Platycheirus (Diptera, Syrphidae) längs den svenska fjällkedjan: en flerårig inventering.

The fauna of hoverflies in Boreal and Arctic parts of Scandinavia is still very poorly investigated. Therefore we performed an 11 year survey of the hoverfly genus Platycheirus Lepeletier & Serville, 1828 along the Caledonian mountain chain in Sweden (from Värmland northwards to the Torneträsk area). During 2003-2013 we annually performed two trips in order to survey various areas and to colle

Singular inverse Wishart distribution and its application to portfolio theory

The inverse of the standard estimate of covariance matrix is frequently used in the portfolio theory to estimate the optimal portfolio weights. For this problem, the distribution of the linear transformation of the inverse is needed. We obtain this distribution in the case when the sample size is smaller than the dimension, the underlying covariance matrix is singular, and the vectors of returns a

Äldre cyklister

Syftet med denna studie är att studera hur äldre personer ser på cykeln och vilka möjligheter cykeln ger, vad som får en äldre person att sluta cykla och vilken påverkan det får samt hur olycksbilden och hjälmanvändningen ser ut bland äldre personer. Tre delstudier genomfördes, en kvantitativ enkätundersökning bland personer som är 65 år och äldre, fokusgruppsintervjuer med äldre cyklister och ana

The influence of the local structure of Fe(III) on the photocatalytic activity of doped TiO2 photocatalysts-An EXAFS, XPS and Mossbauer spectroscopic study

Fe(III)-doped TiO2 based heterogeneous photocatalysts were prepared by the sol-gel technique (S samples) or flame hydrolysis (F samples). In photocatalytic phenol decomposition, the undoped F-sample performed much better, than the undoped S one. However, for the S samples, photocatalytic activity first increased with the increasing Fe(III) concentration, and then passed through a maximum, while Fe

Fyrtiotalisterna och äldreomsorgen - massmediala konstruktioner av en ny sorts omsorgstagare

Baby boomers and elderly care: expectations in print media about a new kind of care users The Swedish baby boomer generation known as the forties generation has been characterized as youthful and powerful. At present, members of this generation are entering the category of old age and in about ten years they will start reaching ages where the likelihood of encountering elderly care increases signi