Colorectal cancer (CRC) is one of the major causes of cancer globally. Recent studies proposed a role for cancer initiating cells (CICs), a small subset of replication-competent cells, in colon carcinogenesis. Although the role of inflammatory lipid-mediators in CRC progression is well known, their role in the promotion of cancer-initiating cells remains to be elucidated. For this thesis, we inves

High-pressure homogenizers (HPHs) are used to create sub-micron emulsions in low-viscosity fluids. As the flow in a real HPH is very extreme, with gaps ranging from 10 to 100 pm and high velocities, it is almost impossible to visualize the drop break-up process. In this study a plastic scale model of a HPH was made, allowing the visualization of drop deformation and break-up. Great care was taken

A critical review of Carlos Castaneda's work.

T lymphocytes are a critical cellular component of the adaptive immune response. They are generated in the thymus from bone marrow derived progenitors, where they undergo commitment to the T cell lineage and differentiate and mature into naïve CD4+ and CD8+ T cells. Naïve CD4+ and CD8+ T cells activation takes place in lymphoid organs after recognition of cognate antigen in the context of major hi

A new method for calibrating the hadron response of a segmented calorimeter is developed and successfully applied to beam test data. It is based on a principal component analysis of energy deposits in the calorimeter layers, exploiting longitudinal shower development information to improve the measured energy resolution. Corrections for invisible hadronic energy and energy lost in dead material in

A parasite's ability to be a specialist vs. a generalist may have consequences for its prevalence within one or more if its host species. In this study we investigated the relationship between host specialization and prevalence in the highly species diverse avian blood parasites of the genera Plasmodium and Haemoproteus. Contrary to trade-off hypotheses that may explain host specialization, within

Background: The teenage years are the years when adolescents seek their identity, and part of this involves experimenting with tobacco. The use of tobacco as such, and norms among their friends, is more important to the adolescents than the norms of parents when it comes to using tobacco or not. The aim was to explore the significance of using snus for adolescents, and attitudes to snus, as well a

The deswelling behavior of cross-linked DNA gels reports on DNA-cosolute interactions and gives a basis for the development of responsive DNA formulations. An investigation of the deswelling kinetics shows that an increase in the surfactant tail length gives a pronouncedly slower deswelling kinetics. In the same conditions, single stranded gels exhibited faster deswelling kinetics when compared wi

Sverige har ett mäktigt parlament, kanske det mäktigaste i den demokratiska världen. I avsaknad av alla de viktiga instrumenten för horisontell maktdelning har all offentlig makt samlats i riksdagen. Det är dock inte liktydigt med att de svenska riksdagsledamöterna är inflytelserika i motsvarande grad. I vad mån så är fallet bestäms av en rad faktorer, inte minst av valsystemet. Men också riksdage

The current and future emissions regulations and demands on internal combustion engines have increased the need for improvement of the thermal design and engine ef ciency. This paper reports an initial investigation concerning in-cylinder heat transfer. In addition, a literature review in this eld is presented. It was found that no extensive application studies have been performed on full cylinder

Many aspects of human physiology and behavior are seasonally related. Although there are many studies using self-ratings of, for example, subjective health and stress, few involve adjusting effects for seasonal differences. To estimate the need of adjusting for season in field studies, 24 healthy men and women were studied in a design that required them to fill in questionnaires on one workday eve

This paper analyses a specific stage in the development of alignment system in Indo-European languages. It is argued that one of the most crucial stages is the appearance of binary features, which allows the language to develop into a form ready for dealing with complex functional demands.

Popular Abstract in Swedish Hjärnan är ett organ som utgör 2 % av kroppsvikten men som mottar ca 20 % av hjärtats minut volym och har en mycket hög energi konsumtion. I samband med en blodpropp i något av hjärnas blodkärl eller att ett av hjärnans kärl brister får man en stroke eller cerebral ischemi. Man har under många decennier inriktad sig på den akuta behandlingen på att finna ett sätt att reCerebral arteries participate actively in the response that follows an episode of cerebral ischemia in man and rat. It has been shown that the vascular endothelin receptor expression is increased in stroke and organ culture. Furthermore, studies have demonstrated the intracellular signalling pathways, leading to the enhanced expression of vascular endothelin receptors. We have revealed that both c

Stigma and discrimination are still prominent features of the life situation of persons with mental illness, adding to the burden of the illness, causing a lowered self-esteem, quality of life and affecting possibilities of adequate housing and work. It is also a major barrier to help seeking. The deinstitutionalization of mental health services has led to a significant increase in contacts betwee