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Atherosclerosis is a chronic inflammatory disease and the leading cause of myocardial infarction and stroke. Accumulation, aggregation and subsequent oxidation of LDL in the arterial wall are considered as key events in the development of atherosclerosis. The oxidation of LDL generates reactive aldehydes, including malondialdehyde (MDA) that modifies ApoB in LDL. Immune responses against MDA-modif
Förintelsens röfda nejlika behandlar framför allt Raoul Wallenbergs verkningshistoria, det vill säga hur han har diskuterats och representerats efter hans försvinnande 1945. En aspekt är det politiska och diplomatiska spelet kring honom, i Sverige, USA och Ungern. En annan är framställningen av honom i monument, på film och i tv-serier. Dessutom analyseras sambanden mellan det hemliga, diplomatisk
This article explains how infrastructures with a sustainability record may evolve over time into a lock-in that slows the emergence of more sustainable urban infrastructures. A study of waste incineration in the Goteborg Metropolitan Area, Sweden, serves as an illustrative case. Taking leads from Unruh (2000, 2002), four rationales of lock-in are identified in the case: institutional, technical, c
A concept for time-sensitive optical detectors is described that shows how to confirm whether the detection device is operating in the linear response regime. By evaluating the recorded time decay of a thermographic phosphor, even weak saturation effects far from obvious situations can be identified and further related to either optical or electrical saturation. The concept has been validated by r
It is well known that increased growth and survival of cancer cells often is a result of dysregulated kinase activity and aberrant kinase signaling. The receptor tyrosine kinase c-Kit and its ligand SCF are contributors to this phenomenon in a variety of human cancers, for example hematological malignancies, germ cell tumors and gastrointestinal stromal tumors. In this thesis I have investigated
Objective Systemic sclerosis (SSc) is associated with a significant reduction in life expectancy. A simple prognostic model to predict 5-year survival in SSc was developed in 1999 in 280 patients, but it has not been validated in other patients. The predictions of a prognostic model are usually less accurate in other patients, especially from other centres or countries. A study was undertaken to v
The filamentous bacterium Microthrix parvicella causes severe separation and foaming problems at wastewater treatment plants (WWTPs). An effective control of the bacterium in activated sludge WWTPs can be accomplished by dosage with polyaluminium chloride (PAX-14). The purpose of this study was to investigate whether addition of PAX-14 affects surface properties such as the hydrophobicity of the b
Acute myeloid leukemia (AML) is a highly malignant disease of myeloid cell line. AML is the most frequent adult leukemia with inadequate treatment possibility. The protein phosphatases are critical regulators of cell signaling, and deregulation of protein phosphatases always contribute to cell transformation. Although many studies established a relationship between protein phosphatases and leukemi
Background: Epidemiologic studies have produced conflicting results with respect to an association of dietary fat with breast cancer. Objective: We aimed to investigate the association between fat consumption and breast cancer. Design: We prospectively investigated fat consumption in a large (n = 319 826), geographically and culturally heterogeneous cohort of European women enrolled in the Europea
The cross section for the production of W bosons with subsequent decay W -> tau nu(tau) is measured with the ATLAS detector at the LHC. The analysis is based on a data sample that was recorded in 2010 at a proton-proton center-of-mass energy of root s = 7 TeV and corresponds to an integrated luminosity of 34 pb(-1). The cross section is measured in a region of high detector acceptance and then ext
There is a wide variation in sensitivity to lead (Pb) exposure, which may be due to genetic susceptibility towards Pb. We investigated whether a polymorphism (rs1800435) in the delta-aminolevulinic acid dehydratase (ALAD) gene affected the toxicokinetics and toxicodynamics of Pb. Among 461 Chinese Pb-exposed storage battery and 175 unexposed workers, allele frequencies for the ALAD1 and ALAD2 alle
The overall aim of this thesis was to investigate utilization of medical healthcare, i.e. hospital care and outpatient care, over a period of 1 to 5 years among people aged 65 years or older. The aim was further to investigate medical healthcare utilization in relation to the predisposal factors age and sex; the enabling factors functional ability, cognitive ability, informal care, municipal long-
Ett nationellt svenskt forskningsprogram HÖGPRESTERANDE BETONG finansierat av de statliga organisationerna NUTEK och BFR och ett antal företag i byggbranschen genomfördes under åren 1991‐1997. I programmet deltog forskare från de fyra tekniska högskolorna CTH, KTH, LuTH (nuvarande LTU) och LTH. Dessutom deltog forskare från Cement och Betongforskningsinstitutet, CBI, samt forskare från olika finanA national Swedish research program HIGH PERFORMANCE CONCRETE was sponsored by the governmental organizations NUTEK and BFR and by a number of private companies within the building sector. The program was performed during the years 1991‐1997. Researchers from four Swedish technical institutes, from the Swedish Cement and Concrete Research Institute and from private companies took part in the progr
Background: Animal migration requires adaptations in morphological, physiological and behavioural traits. Several of these traits have been shown to possess a strong heritable component in birds, but little is known about their genetic architecture. Here we used 454 sequencing of brain-derived transcriptomes from two differentially migrating subspecies of the willow warbler Phylloscopus trochilus
The O, N, and C 1s core level photoemission spectra of the nucleobases cytosine and uracil have been measured in the vapor phase, and the results have been interpreted via theoretical calculations. Our calculations accurately predict the relative binding energies of the core level features observed in the experimental photoemission results and provide a full assignment. In agreement with previous
