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It is unclear how telomere-binding protein TPP1 interacts with human telomerase reverse transcriptase (hTERT) and influences cervical cancer development and progression. This study included all eligible 156 cervical cancers diagnosed during 2003-2008 and followed up through 2014, 102 cervical intraepithelial neoplasia (CIN) patients, and 16 participants with normal cervix identified at the same pe
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is commonly diagnosed at an advanced stage. Liquid biopsy approaches may facilitate detection of early stage PDAC when curative treatments can be employed.DESIGN: To assess circulating marker discrimination in training, testing and validation patient cohorts (total n=426 patients), plasma markers were measured among PDAC cases and patients with ch
One of the most prominent tools to explore sustainable futures are integrated assessment models (IAMs). Although IAMs have analytical strengths, their limitations risk closing-down imaginaries of sustainable futures. Critics therefore argue for a more ‘reflective’ IAM practice, where modellers critically question and reconsider their assumptions and explore futures and their role in climate policy
BACKGROUND: Gene mutations are responsible for a sizeable proportion of cases of heart failure. However, the number of patients with any specific mutation is small. Repositioning of existing US Food and Drug Administration-approved compounds to target specific mutations is a promising approach to efficient identification of new therapies for these patients. METHODS: The National Institutes of Heal
Background: Testicular torsion (TT) is a scrotal emergency that needs urgent detection for successful treatment. Purpose: To investigate the diagnostic value of acute ultrasound and the possibility of more effective detection. Material and Methods: This retrospective study included patients assessed with ultrasound for suspicion of TT between 2019 and 2023. Registration of parameters included symp
Introduction: Malaria remains a persistent challenge in global health, disproportionately affecting populations in endemic regions (eg, sub-Saharan Africa). Despite decades of international collaborative efforts, malaria continues to claim hundreds of thousands of lives each year, with young children and pregnant women enduring the heaviest burden. This concise review aimed to provide an up-to-dat
In what ways could cellular massive MIMO be improved? This technology has already been shown to bring huge performance gains, however, coverage holes and difficulties to transmit multiple streams to multi-antenna users because of insufficient channel rank remain issues. Distributed MIMO, also known as cell-free massive MIMO, might be the ultimate solution. However, while being a powerful technolog
This edited volume critically investigates women’s knowledge about war and explores the epistemic agency of women in a range of contemporary settings across the globe. Women are deeply affected by war, participate in war and resist war. At the same time, knowledge production often ignores and marginalizes women’s experiences and gendered ways of knowing war. From Colombia to Israel and Palestine,
In recent years, the number of people with Alzheimer's disease (AD) has grown worldwide. Since no cure has yet been found for the disease, detection and initiation of treatment is the best way to prevent the disease from progressing behavioral and physical symptoms in the patient. There are several methods to diagnose AD, and neuroimaging, as a noninvasive approach, reveals changes in the brain du
Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of genetic variability. However, mechanistic analysis of whether and how L1s contribute to human developmental programs is lacking, in part due to the challenges associated with specific profiling and manipulation of human L1 expression. Here, we show that thousands of hominoid-specific L1 integrants are expressed in
Combining multiple III-V materials into axial nanowire heterostructures has enabled the fabrication of custom nanowire-based devices useful for a wide range of applications. However, our ability to form axial heterostructures between arbitrary combinations of III-V compounds is impeded by a lack of information on the dynamics of the heterojunction formation process, often resulting in suboptimal h
Satellite-based Synthetic Aperture Radar Interferometry (InSAR) monitoring is a potential complement to conventional Structural Health Monitoring (SHM) methods, due to its non-invasive nature and high spatial coverage. These characteristics allow for continuous monitoring without disrupting bridge operations and enable the exploration of historical data for trend analysis and proactive maintenance
Eastern New South Wales (NSW), Australia, is a region prone to frequent and intense droughts. An unprecedented episode of high temperatures and low rainfall in 2017–2019 culminating in the 2019-2020 summer triggered massive canopy dieback of eucalypt forests throughout the region. Subsequent high rainfall in 2020 offered a unique and rare opportunity to study the process of vegetation recovery fol
RNA modifying enzymes play a pivotal role in reshaping gene expression programs in response to diverse intracellular and extracellular cues, thereby maintaining cellular homeostasis. When dysregulated, these enzymes are increasingly implicated in the onset and progression of various diseases. While traditionally recognised for their catalytic functions, mounting evidence suggests that many RNA mod
Pixel sensors in 3D technology equip the outer ends of the staves of the Insertable B Layer (IBL), the innermost layer of the ATLAS Pixel Detector, which was installed before the start of LHC Run 2 in 2015. 3D pixel sensors are expected to exhibit more tolerance to radiation damage and are the technology of choice for the innermost layer in the ATLAS tracker upgrade for the HL-LHC programme. While
The human brain is a complex and finely tuned organ, constantly monitored and maintained by its resident immune cells.Among these, microglia are the primary regulators of the brain immune environment under physiological conditions, and monocyte-derived macrophages contribute mainly to pathological states such as ischemic stroke and neuronopathic Gaucher’s disease (GD). These two diseases, although
