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Nonagenarians qualify for total knee arthroplasty : a report on 329 patients from the Swedish Knee Arthroplasty Register 2000–2016

Background and purpose — The nonagenarian (those aged 90 years and older) population is expected to double in the next 20 years. This demographic age quake may have a significant impact on the incidence of total knee arthroplasty (TKA), although current literature provides limited data. We examined death and revision rates, patient-reported outcomes (PROs) and bias on patient selection of nonagena

Thymic Stroma and T Cell Development. Impacts of Retinoic Acid Signaling

The development of functionally competent, self-tolerant T cells in the thymus is an essential prerequisite for the formation of adaptive immune responses against foreign pathogens. Thymic epithelial cells (TECs) form specialized stromal microenvironments in the cortex (cTEC) and medulla (mTEC) of the thymus that support all stages of T cell development, from the entry of thymocyte progenitors to

The burden of disease in Greece, health loss, risk factors, and health financing, 2000-16 : an analysis of the Global Burden of Disease Study 2016

BACKGROUND: Following the economic crisis in Greece in 2010, the country's ongoing austerity measures include a substantial contraction of health-care expenditure, with reports of subsequent negative health consequences. A comprehensive evaluation of mortality and morbidity is required to understand the current challenges of public health in Greece.METHODS: We used the results of the Global Burden

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016 : A Systematic Analysis for the Global Burden of Disease Study

Importance: The increasing burden due to cancer and other noncommunicable diseases poses a threat to human development, which has resulted in global political commitments reflected in the Sustainable Development Goals as well as the World Health Organization (WHO) Global Action Plan on Non-Communicable Diseases. To determine if these commitments have resulted in improved cancer control, quantitati

Budgetary Impact of Medicinal Therapies for Rare Diseases in Bulgaria

BACKGROUND: Rare diseases have been continually outlined as one of the causes for the National Health Insurance Fund's (NHIF) deficit spending in Bulgaria.AIM: To estimate the budgetary impact of rare disease medicinal therapies from NHIF perspective for 2014 and 2016.MATERIALS AND METHODS: Budgetary impact of rare diseases is calculated as a percentage of NHIF total pharmaceutical spending. Total

Paleolithic diets

If, as indicated by some studies, prudent diets such as the Mediterranean or DASH diets can be further improved, an evolutionary approach may be helpful. Paleolithic diets represent the food habits during more than two million years of hominid and human evolution before the development of agriculture. Fruits, tubers, nuts, lean meat, larvae, insects, fish, shellfish, eggs, honey, and a large varie

Using the thermal mass of a building to reduce the magnitude of the peak power demand of the primary heating system : A whole building simulation with parametric analysis

The idea of using the thermal mass of a building to maintain a more constant indoor climate is not new. This particular propertyof a building, including its exterior envelope, plays an important part in the reduction of peak power demands, which is becomingan increasingly urgent issue for the heating energy suppliers. The latest smart-grid technology creates new opportunities wherecommunication be

Navigating the Activity Based Working Environment : Relationships of self-leadership, autonomy and information richness with cognitive stress and performance

In Activity Based Working Environment (ABWE) offices, employees are allowed increased autonomy and are expected to choose where, when, with whom, and to some degree with what, to work; in other words, employees are expected to self-lead to a higher degree and to coordinateand align with colleagues. Effectsof these expectations on employees’cognitive stress and performanceare understudied. In the p

Syndicated Lending: The Role of Relationships for the Retained Share

The finance literature offers ambiguous predictions about the impact of lending relationships on the share retained by lead arrangers in syndicated loans. While some literature indicates that lending relationships can help to alleviate post contractual agency conflicts, others imply that relationship lead arrangers may use their information advantage to exploit syndicate participants. Using syndic

A protein complex from human milk enhances the activity of antibiotics and drugs against Mycobacterium tuberculosis

Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB), has surpassed HIV/AIDS as the leading cause of death from a single infectious agent. The increasing occurrence of drug-resistant strains has become a major challenge for health care systems and, in some cases, has rendered TB untreatable. However, the development of new TB drugs has been plagued with high failure rates and

Electrical Properties of Vertical InAs/InGaAs Heterostructure MOSFETs

Vertical InAs/InGaAs nanowire MOSFETs are fabricated in a gate-last fabrication process, which allows gate-lengths down to 25 nm and accurate gate-alignment. These devices demonstrate high performance with transconductance of 2.4 mS/μm, high on-current, and off-current below 1 nA/μm. An in-depth analysis of the heterostructure MOSFETs are obtained by systematically varying th

Test method for de-icing salt-frost scaling in high-performance concrete

This paper describes a de-icing salt-frost scaling test method for analysis of the salt-frost scaling behaviour in high-performance concrete with various binders. The method was therefore designed to result in considerable scaling damage for the concrete considered to be salt-frost resistant. In addition, the experimental set-up was designed to avoid leakage, and to allow testing of a large number

Facilitators to support the implementation of injury prevention training in youth handball - A concept mapping approach

There is a need for research to identify effective implementation strategies for injury prevention training within real-world community sports. The aim of this ecological participatory study was to identify facilitators, among stakeholders at multiple levels, that could help injury prevention training become part of regular training routines in youth team handball. Concept mapping, a mixed-method