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A chimeric reporter gene allowing for clone selection and high-throughput screening of reporter cell lines expressing G-protein-coupled receptors

Efficient screening of ligands interacting with G-protein-coupled receptors is central for modern drug development. Here, we describe an optimized reporter vector primarily intended for use in reporter cell lines expressing such receptors. The construct consists of a synthetic enhancer containing 9x TRE (12-O-tetradecanoylphorbol-13-acetate-responsive elements) fused to a minimal CMV (cytomegalovi

Detection of acute ischemia from the EASI-derived 12-lead electrocardiogram and from the 12-lead electrocardiogram acquired in clinical practice

ST-segment measurements in the standard 12-lead electrocardiogram (ECG) of patients with acute coronary syndromes are crucial for these patients' management. Our objective was to determine whether the 12-lead ECG derived from the 3-lead EASI system can attain a level of diagnostic performance similar to that of the Mason-Likar (ML) 12-lead ECG acquired in clinical practice (CP) by paramedics and e

Plasma apolipoprotein M is reduced in metabolic syndrome but does not predict intima media thickness

Background: Apolipoprotein (apo) M may exert anti-atherogenic properties in experimental studies. Its hepatic gene expression may be linked to glucose and lipid metabolism. Plasma apoM is decreased in obese mouse models. We hypothesized that plasma apoM is lower in metabolic syndrome (MetS) subjects, and determined whether intima media thickness (IMT) is associated with apoM. Methods: In 19 non-di

Gram-positive anaerobic cocci - commensals and opportunistic pathogens.

Among the Gram-positive anaerobic bacteria associated with clinical infections, the Gram-positive anaerobic cocci (GPAC) are the most prominent and account for approximately 25-30% of all isolated anaerobic bacteria from clinical specimens. Still, routine culture and identification of these slowly growing anaerobes to the species level has been limited in the diagnostic laboratory, mainly due to t

Effect of Compressed Offline Foveated Video on Viewing Behavior and Subjective Quality

Offline foveation is a technique to improve the compression efficiency of digitized video. The general idea behind offline foveation is to blur video regions where no or a small number of previewers look without decreasing the subjective quality for later viewers. It relies on the fact that peripheral vision is reduced compared to central vision, and the observation that during free-viewing humans

Affective stress responses during leisure time: Validity evaluation of a modified version of the Stress-Energy Questionnaire.

Psychosocial stress at work is one of the most important factors behind increasing sick-leave rates. In addition to work stressors, it is important to account for non-work-related stressors when assessing stress responses. In this study, a modified version of the Stress-Energy Questionnaire (SEQ), the SEQ during leisure time (SEQ-LT) was introduced for assessing the affective stress response durin

Labour Market Externalities and Regional Growth in Sweden: The Importance of Labour Mobility between Skill-Related Industries

Regional Studies. This study investigates the relationship between labour market externalities and regional growth based on real labour flows. In particular, it tests for the importance of labour mobility across so-called skill-related industries between 435 four-digit industries within 72 Swedish functional regions (1998-2002). Both the fixed-effect models and generalized method of moments (GMM)

Neuropsychiatric and behavioral profiles of 2 adults with williams syndrome: response to antidepressant intake.

Background: Individuals with Williams syndrome, a rare genetic disorder, are characterized by specific medical, cognitive, and behavioral phenotypes and often have high anxiety levels as well as phobia. Studies of the psychiatric phenotype in adults affected by Williams syndrome or literature on the management of their mental pathologies are lacking. Method: In this article, we report the neuropsy

Extent and characteristics of self-reported pain in patients with systemic lupus erythematosus

Objective: Patients' own experiences of subjective symptoms are scarcely covered, and the objective of this study was to investigate the extent and characteristics of self-reported pain in patients with systemic lupus erythematosus (SLE). Methods: This study comprised a cross-sectional design where 84 patients with SLE were asked to complete self-assessments: visual analogue scale of pain and the

Simultaneous detoxification and enzyme production of hemicellulose hydrolysates obtained after steam pretreatment

In the process of making ethanol from lignocellulosic materials, compounds inhibitory to microorganisms are generated during steam pretreatment of the wood. Water-soluble inhibitors and pentoses are liberated and washed from the cellulose structure which is further enzymatically hydrolyzed. To make the process economically feasible, rite pentoses have to be fermented to ethanol. A major drawback w

Diktaren i medieåldern: Om relationen mellan film och lyrik i Bruno K. Öijers verk

ag arbetar för närvarande på ett projekt om relationer mellan film och lyrik. Detta är ett tämligen outforskat område, inte minst vad gäller fenomenet ”den filmatiserade diktsamlingen”. vanligtvis diskuteras och undersöks prosaberättelsens relation till filmmediet, och mer sällan lyrikens dito. I mitt paper kommer jag att behandla två aspekter: poesi på/i film, samt filmanknytningar i lyrik. Mitt

Formation of internally nanostructured triblock copolymer particles

Particles with an internal structure have been found in dilute water solutions of a triblock copolymer of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), which has short hydrophilic PEO endblocks compared to the central hydrophobic PPO block (EO5PO68EO5, L121). The properties of the block copolymer particles (i.e., their structure, size, and time stability) have been investigated using

Synovial fluid acidosis correlates with radiological joint destruction in rheumatoid arthritis knee joints

Metabolic variables in samples of synovial fluid (SF) from 33 rheumatoid arthritis (RA) knees were analyzed. These variables were correlated with radiological destruction and SF proteoglycan concentrations. SF acidosis correlated with radiological involvement (rs = 0.62, p less than 0.002), but not with proteoglycan concentrations. A weak correlation was found between SF acidosis and granulocyte c

Early response predicts thalidomide efficiency in patients with advanced multiple myeloma

Sixty-five patients who were primary or secondary refractory to melphalan/prednisone or other type of chemotherapy, or relapsed within 6 months after high dose chemotherapy with stem cell support, were given thalidomide at a dose of 200 mg/d escalating to 800 mg. The patients were followed for a median of 2 years and 22 weeks. Response was evaluated according to M-protein reduction combined with i

Norms in international relations: some theoretical and methodological reflections

Acknowledging the social constructivist turn in the study of norms, this article offers to demonstrate that the notion of norms is useful as an analytical tool and likely to become a lasting element in international relations theory. Ideational causality and the independent explanatory power of norms are methodological issues that have been debated widely. Despite arguing that norms matter, social