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Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22

Objectives Osteoarthritis (OA) is the most prevalent form of arthritis and accounts for substantial morbidity and disability, particularly in older people. It is characterised by changes in joint structure, including degeneration of the articular cartilage, and its aetiology is multifactorial with a strong postulated genetic component. Methods A meta-analysis was performed of four genome-wide asso

Troponin I and Creatine Kinase MB do not provide comparable information after PCI

Objectives. To compare cardiac troponin I (cTnI) and creatine kinase-MB (CK-MB) after PCI in cases with normal baseline levels of both biomarkers. Design. cTnI and CK-MB after PCI were stratified as multiples of the 99 3x99%URL in 58/486 patients (12%) and cTnI > 3x99%URL in 292/487 patients (60%). cTnI was > 10x99%URL in all cases with infarction according to CK-MB but CK-MB was often normal desp

Frequency Modulation in mm-Wave InGaAs MOSFET/RTD Wavelet Generators

Co-integration of an InGaAs MOSFET and an RTD is performed to realize a wavelet generator. The large transconductance of the MOSFET (1.9 mS/mu m) is used to switch the current in an oscillator circuit and coherent wavelets down to 41 ps are generated in the frequency domain of 50 to 100 GHz. The lowest power consumption measured is 1.9 pJ/pulse. It is found that the supply bias can be used to modu

Simulation of a suite of generic long-pulse neutron instruments to optimize the time structure of the European Spallation Source

We here describe the result of simulations of 15 generic neutron instruments for the long-pulsed European Spallation Source. All instruments have been simulated for 20 different settings of the source time structure, corresponding to pulse lengths between 1 ms and 2 ms; and repetition frequencies between 10 Hz and 25 Hz. The relative change in performance with time structure is given for each inst

Novel Cutaneous Human Papillomaviruses and Biomarkers in the Skin Lesions

Non-melanoma skin cancer (NMSC), comprising of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), is the most prevalent cancer amongst Caucasians. The main risk factor for the development of NMSC is UV-irradiation but human papillo-mavirus (HPV) might be a co-factor. We extended the heterogeneity of the genus Betapapillomavirus by characterizing six putative types, HPV93 (species 1), 96

Increased abdominal obesity, adverse psychosocial factors and shorter telomere length in subjects reporting early ageing; the MONICA Northern Sweden Study

Background: The rate of biological ageing is individual and represents the steady decrease in physiological and mental functions. Adverse social factors have been shown to influence this process. Self-perceived early ageing (SEA) might be a useful indicator of early biological ageing and increased mortality risk. The aim of this population-based study was to identify markers of SEA, including telo

Individual differences in processing styles: validity of the Rational-Experiential Inventory.

In Study 1 (N= 203) the factor structure of a Swedish translation of Pacini and Epstein's Rational-Experiential Inventory (REI-40) was investigated using confirmatory factor analysis. The hypothesized model with rationality and experientiality as orthogonal factors had satisfactory fit to the data, significantly better than alternative models (with two correlated factors or a single factor). Inclu

Computational fluid dynamics model development on transport phenomena coupling with reactions in intermediate temperature solid oxide fuel cells

A 3D model is developed to describe an anode-supported planar solid oxide fuel cell (SOFC), by ANSYS/Fluent evaluating reactions including methane steam reforming (MSR)/water-gas shift (WGSR) reactions in thick anode layer and H-2-O-2/CO-O-2 electrochemical reactions in anode active layer, coupled with heat, mass species, momentum, and ion/electron charges transport processes in SOFC. The predicte

Contrasting Short-Term Antibiotic Effects on Respiration and Bacterial Growth Compromises the Validity of the Selective Respiratory Inhibition Technique to Distinguish Fungi and Bacteria.

The selective inhibition (SI) technique has been widely used to resolve fungal and bacterial biomass. By studying bacterial growth (leucine/thymidine incorporation) and respiration simultaneously, this study demonstrates that the inhibitors the SI technique is based on do not efficiently or specifically resolve fungal and bacterial contributions to respiration. At concentrations that completely in

Child healthcare nurses believe that bilingual children show slower language development, simplify screening procedures and delay referrals

AimA significant number of children living in Sweden are bilingual, but how language screening is performed in this group is unknown. We investigated child healthcare nurses' perceptions of the language screening of bilingual children aged 30-36months, together with their clinical practices. MethodsAn online questionnaire was completed by 863 nurses who performed language screening of bilingual ch

Acupuncture compared with placebo acupuncture in radiotherapy-induced nausea-a randomized controlled study

It is not known if verum (real) acupuncture is effective for nausea and vomiting (emesis) during radiotherapy. We randomly treated 215 blinded cancer patients with verum: penetrating 'deqi' creating acupuncture (n = 109) or non-penetrating sham needles (n = 106) two to three times per week. The patients documented emesis daily during the radiotherapy period. Primary end point was the number of pat

On the New Passive

The so-called New Passive in Icelandic takes the form 'it was elected us' (or, e.g., 'then was elected us', without an expletive), instead of the standard passive form 'we were elected'. It has neither A-movement to subject nor acc-to-nom conversion, which are otherwise diagnostic of the canonical passive in Icelandic and related languages. Some researchers have argued that "passive" is in fact a

On the strategies for incorporating nanosilica aqueous dispersion inthe synthesis of waterborne polyurethane/silica nanocomposites:Effects on morphology and properties

In this work the synthesis of waterborne polyurethane/nanosilica nanocomposites by using two differ-ent strategies is presented, starting from a vinyl terminated polyurethane prepolymer (PUP) based onisophorone diisocyanate and polypropylene glycol, and varying the nanosilica content. In one case, thePUP was dispersed in an aqueous solution containing glycerol-functionalized colloidal nanosilica p

Large Eddy Simulation of a premixed jet flame stabilized by a vitiated co-flow: Evaluation of auto-ignition tabulated chemistry

A tabulation technique assuming an auto-ignition dominated reaction pathway for highly turbulent premixed combustion is presented, implemented in an LES framework and evaluated. The tabulation method enables the reduction of the chemical system dimension to two scalars, allowing a computationally efficient model implementation, yet still retaining a sufficiently accurate representation of the chem