Type 2 diabetes (T2D) is characterized by insulin resistance and impaired insulin secretion, but the mechanisms underlying insulin secretion failure are not completely understood. Here, we show that a set of co-expressed genes, which is enriched for genes with islet-selective open chromatin, is associated with T2D. These genes are perturbed in T2D and have a similar expression pattern to that of d

Bmi1 was originally identified as a gene that contributes to the development of mouse lymphoma by inhibiting MYC-induced apoptosis through repression of Ink4a and Arf. It codes for the Polycomb group protein BMI-1 and acts primarily as a transcriptional repressor via chromatin modifications. Although it binds to a large number of genomic regions, the direct BMI-1 target genes described so far do n

Pancreatic endocrine cell differentiation depends on transcription factors that also contribute in adult insulin and glucagon gene expression. Islet cell development was examined in mice lacking MafB, a transcription factor expressed in immature alpha (glucagon(+)) and beta (insulin(+)) cells and capable of activating insulin and glucagon expression in vitro. We observed that MafB(-/-) embryos had

We present measurements of long-range angular correlations and the transverse momentum dependence of elliptic flow v2 in high-multiplicity p+Au collisions at sNN=200 GeV. A comparison of these results to previous measurements in high-multiplicity d+Au and He3+Au collisions demonstrates a relation between v2 and the initial collision eccentricity 2, suggesting that the observed momentum-space azimu

Extracts obtained from liquid mycelial fermentations of the Chilean fungus Stereum hirsutum (Sh134-11) showed antifungal activity against Botrytis cinerea. Two types of extracts were obtained: EtOAc-extract (liquid phase) and MeOH-extract (mycelial phase). Plate diffusion assay showed that EtOAc-extracts were more active than MeOH-extracts. A large-scale fermentation of Sh134-11 and chromatographi

Starch and hence, amylopectin is an important biomacromolecule in both the human diet as well as in technical applications. Therefore, accurate and reliable analytical methods for its characterization are needed. A suitable method for analyzing macromolecules with ultra-high molar mass, branched structure and high polydispersity is asymmetric flow field-flow fractionation (AF4) in combination with

The PHENIX Collaboration has measured the ratio of the yields of ψ(2S) to ψ(1S) mesons produced in p+p, p+Al, p+Au, and He3+Au collisions at sNN=200 GeV over the forward and backward rapidity intervals 1.2

The present volume brings together six articles which all address issues of censorship in music. While restrictions on free speech in popular music are often ascribed to the semantic content of lyrics or images, the authors in this special issue take their point of departure from the perception that the musical sound in its complexity rather plays a major role in silencing musicians and artists. D

We describe the finding of an urban roost of wintering Barn Swallows Hirundo rustica in Aveiro, Portugal, which remained stable with c.150 individuals from at least early December to mid-January 2015/16. The stability in numbers and the occurrence of freshly-shed primary feathers below the roost strongly indicate that these were indeed wintering birds that completed their annual moult and suffered

The dynamics of isolated-photon plus one-, two- and three-jet production in pp collisions at a centre-of-mass energy of 8 TeV are studied with the ATLAS detector at the LHC using a data set with an integrated luminosity of 20.2 fb−1. Measurements of isolated-photon plus jets cross sections are presented as functions of the photon and jet transverse momenta. The cross sections as functions of the a

The first study of ϕ-meson production in p–Pb collisions at forward and backward rapidity, at a nucleon–nucleon centre-of-mass energy sNN=5.02 TeV, has been performed with the ALICE apparatus at the LHC. The ϕ-mesons have been identified in the dimuon decay channel in the transverse momentum (pT) range 1

A nonlinear least squares method for continuous measurement ofthe air flow in a 'dynamic insulation' was presented. The methodis called the gradient method to indicate that the temperature gradientsin the insulation are used. The method includes one dimensionaltransient and steady state calculations ofthe heat transfer inthe insulation. The model was verified by analytical and numericalsimulations

Respiratory mechanics, using flow interruption, was previously studied during the complete breath in healthy ventilated man, numerical techniques relieving constraints regarding flow pattern. The classical linear model of non-Newtonian behaviour was found to be valid. The present study was extended to subjects with critical lung disease. Subjects with acute lung injury (ALI; n = 2), acute respirat

The classic model of the respiratory system (RS) is comprised of a Newtonian resistor in series with a capacitor and a viscoelastic unit including a resistor and a capacitor. The flow interruption technique has often been used to study the viscoelastic behavior under constant inspiratory flow rate. To study the viscoelastic behavior of the RS during complete respiratory cycles and to quantify visc

We examined the relationship between pulmonary density, measured with computerized tomography, and pulmonary mechanics (static pulmonary volume; pulmonary resistance) in 39 normal subjects (20 nonsmokers and 19 smokers). Pulmonary density decreased with increasing static elastic recoil pressure, and smokers consistently showed higher pulmonary density than nonsmokers. Pulmonary density, measured a

We present a supersymmetric (SUSY) model based on trinification [SU(3)]3 and family SU(3)F symmetries embedded into a maximal subgroup of E8, where the sectors of light Higgs bosons and leptons are unified into a single chiral supermultiplet. The common origin of gauge trinification and of the family symmetry from E8 separates the model from other trinification-based GUTs, as it protects, in parti

Same- and opposite-sign charge asymmetries are measured in lepton+jets tt¯ events in which a b-hadron decays semileptonically to a soft muon, using data corresponding to an integrated luminosity of 20.3 fb−1 from proton-proton collisions at a centre-of-mass energy of s=√8 TeV collected with the ATLAS detector at the Large Hadron Collider at CERN. The charge asymmetries are based on the charge of t