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OBJECTIVE - Impaired muscular mitochondrial function is related to common insulin resistance in type 2 diabetes. Mitochondrial diseases frequently lead to diabetes, which is mostly attributed to defective beta-cell mitochondria and secretion. RESEARCH DESIGN AND METHODS - We assessed muscular mitochondrial function and lipid deposition in liver (hepatocellular lipids [HCLs]) and muscle (intramyoce

This paper explores strategic change communication, framed by the idea that managers can be viewed as rhetoricians. The purpose of this paper is to present and discuss senior managers’ subjective experiences of rhetorical aspects of change management. The paper draws on a case study from ABB Sweden (a power and automation technology company). In-depth interviews with senior managers, with vast ex

Introduction to special issue on Business Ethics, in the Journal of Business Anthropology. Today, business ethics can be found everywhere. But how can we define it intellectually? What does this concept include? How can we define it in explicitly anthropological terms? For the manager as well as the anthropologist, business ethics – in thoughts or in actions – involves dealing with opposing notion

Rab7 is a member of small GTP-binding protein family involved in intracellular vesicle trafficking from late endosome to vacuole, some of them are found to be responsive by different environmental stresses. Here we report the isolation of a Rab7 (RabG3b) cDNA from peanut (Arachis hypogaea). Overexpression of the open reading frame (ORF) of Rab7 cDNA encoding 205 amino acids in E. coli conferred th

Background. Sporadic cases of abdominal pain and dysmotility has been described after treatment with gonadotropin-releasing hormone (GnRH) analogs. The aim of the present study was to scrutinize for patients with severe gastrointestinal complaints after treatment with GnRH analogs, to describe the expression of antibodies against progonadoliberin-2, GnRH1, GnRH receptor (GnRHR), luteinizing hormon

Background: We previously reported significant associations between genetic variants in insulin receptor substrate 1 (IRS1) and breast cancer risk in women carrying BRCA1 mutations. The objectives of this study were to investigate whether the IRS1 variants modified ovarian cancer risk and were associated with breast cancer risk in a larger cohort of BRCA1 and BRCA2 mutation carriers. Methods: IRS1

A Mathematica package for color summed calculations in QCD (SU(N-c)) is presented. Color contractions of any color amplitude appearing in QCD may be performed, and the package uses a syntax which is very similar to how color structure is written on paper. It also supports the definition of color vectors and bases, and special functions such as scalar products are defined for such color tensors.

Background: The effect of the macronutrient composition of the usual diet on long term weight maintenance remains controversial. Methods: 373,803 subjects aged 25-70 years were recruited in 10 European countries (1992-2000) in the PANACEA project of the EPIC cohort. Diet was assessed at baseline using country-specific validated questionnaires and weight and height were measured at baseline and sel

In Russia, as in some other countries around the world, we are currently witnessing a wave of politically sanctioned homophobia, most concretely manifested in the 2013 law against “homosexual propaganda”. By examining Russian mainstream media reporting, this article aims to reconstruct a dominant narrative on homosexuality and LGBT rights. It is found that this narrative revolves around three trop

We consider the operator -d(2)/dr(2) - V in L-2(R+) with Dirichlet boundary condition at the origin. For the moments of its negative eigenvalues we prove the bound [GRAPHICS] for any alpha is an element of [0, 1) and gamma >= (1 - alpha)/2. This includes a Lieb-Thirring inequality in the critical endpoint case.

Mathematical modelling has proven to be very useful in process design, operation and optimisation. A recent trend in WWTP modelling is to include the different subunits in so-called plant-wide models rather than focusing on parts of the entire process. One example of a typical plant-wide model is the coupling of an upstream activated sludge plant (including primary settler, and secondary clarifier

Signal crayfish (Pacifastacus leniusculus) have become increasingly widespread in rivers in Great Britain since their introduction in the late 1970s, causing extensive losses of indigenous white-clawed crayfish and negative impacts on communities of aquatic plants, invertebrates and benthic fish. Angling interests are increasingly concerned about possible impacts of signal crayfish on brown trout,

Kuannersuit Glacier, a valley glacier on Disko Island in west Greenland, experienced a major surge from 1995 to 1998 where the glacier advanced 10.5 km and produced a similar to 65 m thick stacked sequence of debris-rich basal ice and meteoric glacier ice. The aim of this study is to describe the tectonic evolution of large englacial thrusts and the processes of basal ice formation using a multipr

Fluids of spherical colloids possessing an off-centered embedded magnetic dipole were investigated by using Monte Carlo simulations. Systems of colloids with different strengths and directions of the embedded dipole moment confined in a 2D space without and with an external magnetic field applied were considered. The fluids were characterized by radial distribution functions, angular distribution

Cationic polymers are used in anionic surfactant formulations to deposit and co-deposit actives on hair or skin surfaces. A series of cationic polymers, natural and synthetic, were investigated with surface and bulk techniques, turbidity measurements and in situ null-ellipsometry on silica surfaces in order to understand three key areas: the relation between the complex that is formed at a surface

Selection on proteins is typically measured with the assumption that each protein acts independently. However, selection more likely acts at higher levels of biological organization, requiring an integrative view of protein function. Here, we built a kinetic model for de novo pyrimidine biosynthesis in the yeast Saccharomyces cerevisiae to relate pathway function to selective pressures on individu

BACKGROUND AND OBJECTIVES: Transfusion of blood products in particular older products is associated with patient morbidity. Previously, we demonstrated a higher incidence of acute lung injury in lipopolysaccharide-treated sheep transfused with stored blood products. As transfusion following haemorrhage is more common, we aimed to determine whether a 'first hit' of isolated haemorrhage would prec