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How smart is specialisation? An analysis of specialisation patterns in knowledge production

To understand how the specialisation patterns of cities differ among scientific fields, we study patterns of knowledge production in Astrophysics, Biotechnology, Nanotechnology and Organic Chemistry in the period 1996-2012. Using keywords from journal publications, we find systematic differences across scientific fields, but remarkable similarities across cities within each field. Biotechnology sh

Squaring attacks on McEliece public-key cryptosystems using quasi-cyclic codes of even dimension

We present a general purpose algorithm for finding low-weight codewords as well as for decoding a received codeword in any quasi-cyclic code whose length and dimension is a multiple of a power of 2. In this paper, we apply the algorithm on a McEliece variant recently proposed by Misoczki et al. (MDPC-McEliece: New McEliece variants from moderate density parity-check codes, 2013). In their paper, t

Svåra samtal med patienter tränas på kurs med skådespelare : En medveten strategi hjälper både läkare och patient

The physician’s communication skill influences the patient’s mental and physical wellbeing, as well as the physician’s own experience of stress. Most patients wish to be informed about their disease, by physicians who are honest, gives time, sustains hope, listens and shows compassion and empathy. Even though there are established guidelines on how to break bad news, the physician must find out an

Mid-term Outcomes of Renal Branches Versus Renal Fenestrations for Thoraco-abdominal Aneurysm Repair

Objective/Background The objective was to investigate renal outcomes following endovascular repair of thoraco-abdominal aortic aneurysms (TAAA) comparing fenestrations with branches for the renal arteries. Methods Renal outcomes following TAAA endovascular repair performed with renal branches were collected from five high volume European centers and compared with renal outcomes following TAAA endo

INFORMEG, a new evaluation system for family medicine trainees : Feasibility in an Italian rural setting

Introduction: In Italy the course to become a general practitioner (GP) lasts 3 years and includes both theoretical and practical study. Different from the theoretical part, until recently the practical activity has not been assessed at all. The Emilia Romagna Regional Health Authority has developed a special program called INFORMEG (Management of Tutoring during the Triennial Specific Training in

Sub-Cycle Control of Strong-Field Processes on the Attosecond Timescale

This PhD thesis deals with the sub-cycle nature of ultrafast phenomena that occur in strong-field light–matter interactions. As it is of interest to control these phenomena, we must understand them in order to manipulate them. The tools at our disposal are intense laser pulses of short duration, and the systems we study are atoms. A host of exotic phenomena may occur in strong-field light–matter i

Long-Time Voice Accumulation During Work, Leisure, and a Vocal Loading Task in Groups With Different Levels of Functional Voice Problems

Objective: The study aimed to examine the vocal behavior and self-assessed vocal health in women with varying everyday vocal load and functional voice problems, including patients with functional dysphonia, in three conditions: work, leisure, and a vocal loading task (VLT). Study Design: This is a longitudinal controlled, clinical trial. Methods: Fifty (n = 50) female subjects were tracked during

Alzheimer's disease cerebrospinal fluid biomarkers predict cognitive decline in lewy body dementia

Introduction: Alzheimer's disease pathologies are common in dementia with Lewy bodies, but their clinical relevance is not clear. CSF biomarkers amyloid beta 1-42, total tau, and tau phosphorylated at threonine 181 reflect Alzheimer's disease neuropathology antemortem. In PD, low CSF amyloid beta 1-42 predict long-term cognitive decline, but little is known about these biomarkers as predictors for

Irreversibility of t-cell specification : Insights from computational modelling of a minimal network architecture

Background/Objectives A cascade of gene activations under the control of Notch signalling is required during T-cell specification, when T-cell precursors gradually lose the potential to undertake other fates and become fully committed to the T-cell lineage.We elucidate how the gene/protein dynamics for a core transcriptional module governs this important process by computational means. Methods We

Sub-cycle ionization dynamics revealed by trajectory resolved, elliptically-driven high-order harmonic generation

The sub-cycle dynamics of electrons driven by strong laser fields is central to the emerging field of attosecond science. We demonstrate how the dynamics can be probed through high-order harmonic generation, where different trajectories leading to the same harmonic order are initiated at different times, thereby probing different field strengths. We find large differences between the trajectories

Spatially and spectrally resolved quantum path interference with chirped driving pulses

We measure spectrally and spatially resolved high-order harmonics generated in argon using chirped multi-cycle laser pulses. Using a stable, high-repetition rate laser we observe detailed interference structures in the far-field. The structures are of two kinds; off-axis interference from the long trajectory only and on-axis interference including the short and long trajectories. The former is rea

Complement inhibitor CSMD1 acts as tumor suppressor in human breast cancer

Human CUB and Sushi multiple domains 1 (CSMD1) is a membrane-bound complement inhibitor suggested to act as a putative tumor suppressor gene, since allelic loss of this region encompassing 8p23 including CSMD1 characterizes various malignancies. Here, we assessed the role of CSMD1 as a tumor suppressor gene in the development of breast cancer in vitro and in vivo. We found that human breast tumor

Genetic Predisposition to Poor Opioid Response in Preterm Infants : Impact of KCNJ6 and COMT Polymorphisms on Pain Relief after Endotracheal Intubation

Background: Single-nucleotide polymorphisms in genes involved in pain control might predispose to exaggerated sensitivity or difference in opioid analgesic effect. The relevance of the KCNJ6 -1250G>A (rs6517442, c.-1787G>A) and the catecholamine-O-methyltransferase (COMT) c.472G>A (rs4680, Val 158 Met) single-nucleotide polymorphisms were studied in preterm infants needing intubation and randomize