Background: Studies have shown conflicting associations between the salivary amylase gene (AMY1) copy number and obesity. Salivary amylase initiates starch digestion in the oral cavity; starch is a major source of energy in the diet. Objective: We investigated the association between AMY1 copy number and obesity traits, and the effect of the interaction between AMY1 copy number and starch intake o

BACKGROUND: The risk of spinal haematoma in patients receiving epidural catheters is estimated using routine coagulation tests, but guidelines are inconsistent in their recommendations on what to do when results indicate slight hypocoagulation. Postoperative patients are prone to thrombosis, and thromboelastometry has previously shown hypercoagulation in this setting. We aimed to better understand

An unresolved issue in innovation studies is to what extent and how innovation is affected by changes in the economic environment of firms. This study elaborates on a theoretical framework that unites theories of innovation as creative response and the economics of complexity. In the empirical section, results from a new micro-based database on Swedish product innovations, 1970–2007, are introduce

Background: Given that metformin is the most common pharmacological therapy for type 2 diabetes, understanding the function of this drug is of great importance. Hepatic metformin transporters are responsible for the pharmacologic action of metformin. However, epigenetics in genes encoding metformin transporters has not been fully elucidated. We examined the DNA methylation of these genes in the li

Western firms locating in China face a business environment that differs from their home country environment. The differences increase uncertainties and are negative for economic performance. However, firms may differ in their ability to overcome the difficulties, depending on their previous experience. In particular, firms with experience from regions similar to China might exhibit relatively bet

Hailed by economists as an idea whose time has come, the `new economic geography' has not been quite as favourably received by geographers. Frequently seen as a prime case of academic imperialism, few appear willing to concede that economists may have something to contribute to economic geography. Conversely, beyond the token reference to vintage publications, economistsoften dismiss geographers'

A fundamental research experiment for thermal fluid-structure-interaction for the verification of a partitioned approach with non-linear material properties is examined. In the following, a specimen is heated as well as cooled within a wind tunnel. The thermal fluid-structure-interaction is first experimentally investigated and subsequently numerically validated. For the numerical simulation, two

Stakeholder participation is considered a key principle for sustainable development in the context of natural resource and disaster risk management. Participatory modelling (PM) is an interactive and iterative process in which stakeholder involvement is supported by modelling and communication tools. Planning and decision-making for sustainable development (SD)integrate three substantive dimension

Denna artikel argumenterar för användandet av prototyping vid utveckling av ABC-modeller för att bli anpassade efter organisationens förutsättningar. Genom att engagera controllers och deras medarbetare i prototypingprojekten kan deras erfarenheter av verksamheten byggas in i ABC-prototyper. På så sätt ökas sannolikheten för att det framväxande informationssystemet också svarar mot medarbetarnas i

The calculation of absorbed dose within patients during external photon beam radiotherapy is reviewed. This includes the modelling of the radiation source i.e. in most cases a linear accelerator (beam modelling) and examples of dose calculation algorithms applied within the patient i.e. the dose engine. For the first part - the beam modelling, the different sources in the treatment head as target,

Arabinofuranosidases degrade arabinose-containing oligo and polysaccharides, releasing l-arabinose, which is a potentially useful sugar, shown to reduce glycemic response under certain conditions. Arabinofuranosidases (Arafs) are frequently found in GH43, one of the most common GH-families encoded in genomes in gut microbiota, and hence it is of interest to increase understanding of the function o

Spices are rich in distinct polyphenols which might act on the gut by inhibiting glucose uptake and modulating appetite responses. To investigate this hypothesis, healthy adults were randomly assigned to receive isovolumetric (220 ml) spice-based (contained total polyphenol concentration to 185 mg gallic-acid equivalents) or control beverages followed by a standard bread breakfast containing 50 g

Recent advancements in almost all aspects of hemophilia treatment have vastly improved patient care and management, and new and emerging treatments hold the promise of further progress. However, there remains a scarcity of data on long-term outcomes in hemophilia, particularly among those patients with inhibitors, for whom no validated outcome assessment tools are currently available. At the 15th

SH-SY5Y neuroblastoma cells are susceptible to differentiation using retinoic acid (RA) and brain-derived neurotrophic factor (BDNF), providing a model of neuronal differentiation. We compared SH-SY5Y cells proteome before and after RA/BDNF treatment using iTRAQ and phosphopeptide enrichment strategies. We identified 5587 proteins, 366 of them with differential abundance. Differentiated cells expr

OBJECT: Subcutaneously intermittent administration of low molecular weight heparin (LMWH-Fragmin®) - (120IU/kgx2 BW) - in unstable angina was introduced clinically during the last year at our Hospital, after reports of the FRISC and FRIC studies as an alternative to continous infusion of standard heparin. In such patients with need for CABG, no data on haemostasis or anticoagulation during CBP had

The article aims to illustrate the multifaceted interlink between climate change, heat, and human rights and discuss in what ways international human rights law may be used to support the development and implementation of policy at various levels to limit adverse effects of climate change on humans in general and right to health in particular. This is done by overviewing the possibilities and limi