There is an increasing demand for real world evidence. The shift towards relative effectiveness assessment increasingly based on real world data is a natural consequence of the shift towards new adaptive pathways for development and introduction of new medicines in cancer care. The increasing number of alternative treatment options will further increase the need for outcomes data to help optimize

Background: The aim of this study was to evaluate the nationwide outcome of children with total colonic aganglionosis (TCA) during the last 20. years. Methods: This was an observational, cross-sectional study where all patients with TCA, including aganglionosis of 0-50. cm of ileum, born in Sweden 1995-2014 were included. Data were collected from the medical records. Patients>. 4. years old withou

Enligt en etablerad teori om utvecklingen av politiskt styre i Europas förflutna går beskattning hand i hand med folkrepresentation. Härskare i finansiella trångmål blev nämligen mer eller mindre tvungna att erbjuda politiska fri- och rättigheter i utbyte mot folkets bidrag till statskassan. I denna avhandling undersöker jag det rakt motsatta antagandet: är det även så att icke-skatter går hand i According to a venerable argument about the formation of political regimes in historical Europe, taxation goes hand in hand with representation, as financial needs forced rulers to trade rights for revenue. In this dissertation I explore the reverse assumption, asking whether it is the case that non-taxation went hand in hand with non-representation? I argue that early modern rulers who had access

We conduct a contest experiment where participants can invest in increasing both the mean and the spread of an uncertain performance variable. Subjects are treated with different prize schemes and in accordance with theory we observe substantial investments in spread. We find that both types of investments can be controlled with a three level prize scheme. However, the control is imperfect and beh

Sustainable and efficient management of a distribution system requires coordination between transportation planning and inventory control decisions. In this context, we consider a one warehouse multi-retailer inventory system with a time-based shipment consolidation policy at the warehouse. This means that there are fixed costs associated with each shipment, and retailer orders are consolidated an

Laser-induced fluorescence is an important technique to study photosynthesis and plants. Information on chlorophyll and other pigments can be obtained. We have been using a mobile laboratory in a Chinese experimental farm setting to study maize (Zea mays L.) leaves by reflectance and fluorescence measurements and correlated the spectroscopic signals to the amount of fertilizer supplied. Further, w

Historically, egg-bound reptile embryos were thought to passively thermoconform to the nest environment. However, recent observations of thermal taxis by embryos of multiple reptile species have led to the widely discussed hypothesis that embryos behaviorally thermoregulate. Because temperature affects development, such thermoregulation could allow embryos to control their fate far more than histo

Absorption of sunlight is the first step in photosynthesis, which provides energy for the vast majority of organisms on Earth. The primary processes of photosynthesis have been studied extensively in isolated light-harvesting complexes and reaction centres, however, to understand fully the way in which organisms capture light it is crucial to also reveal the functional relationships between the in

CO oxidation over Pd(100) and Pd75Ag25(100) has been investigated by a combination of near-ambient-pressure X-ray photoelectron spectroscopy, quadrupole mass spectrometry, density functional theory calculations, and microkinetic modeling. For both surfaces, hysteresis is observed in the CO2 formation during the heating and cooling cycles. Whereas normal hysteresis with light-off temperature higher

In this paper we analyze the double vector meson production in photon–hadron (γh) interactions at pp / pA / AA collisions and present predictions for the ρρ, J/ Ψ J/ Ψ , and ρJ/ Ψ production considering the double scattering mechanism. We estimate the total cross sections and rapidity distributions at LHC energies and compare our results with the predictions for the double vector meson production

The behaviour of sedimenting particles depends on the dust-to-gas ratio of the fluid. Linear stability analysis shows that solids settling in the Epstein drag regime would remain homogeneously distributed in non-rotating incompressible fluids, even when dust-to-gas ratios reach unity. However, the nonlinear evolution has not been probed before. Here, we present numerical calculations indicating th

One of the approaches to modify the McEliece cryptosystem to overcome its large key size is replacing binary Goppa codes with a new structured code. However, this modification makes such cryptosystems encounter some new attacks. There are a few modified McEliece cryptosystem variants which are known to be secure. One of them is the cryptosystem introduced by Baldi et al. which uses quasi-cyclic lo

Wings are a key trait underlying the evolutionary success of birds, bats, and insects. For over a century, researchers have studied the form and function of wings to understand the determinants of flight performance. However, to understand the evolution of flight, we must comprehend not only how morphology affects performance, but also how morphology and performance affect fitness. Natural and sex

Objective: To estimate and compare the lifetime risk of total knee replacement surgery (TKR) for osteoarthritis (OA) between countries, and over time. Method: Data on primary TKR procedures performed for OA in 2003 and 2013 were extracted from national arthroplasty registries in Australia, Denmark, Finland, Norway and Sweden. Life tables and population data were also obtained for each country. Lif

Aims: To compare long-term changes in healthcare utilization and costs for type 2 diabetes patients before and after insulin initiation, as well as healthcare costs after insulin versus non-insulin anti-diabetic (NIAD) initiation. Methods: Patients newly initiated on insulin (n. =2823) were identified in primary health care records from 84 Swedish primary care centers, between 1999 to 2009. First,

Differences in strategic decision making between CEOs and other people are interesting since CEOs make important economic decisions and impact values and norms in society. Our study combines a large stratified random sample of 199 CEOs of medium-size firms with a carefully selected control group of 200 comparable people. All subjects participated in three different incentivized strategic games — P