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Ecolodge Tourism Dynamics : A Village-Level Analysis of Marketing and Policy Indicators in Iran’s Hawraman Region

Despite growing interest in community-based ecotourism as a pathway to sustainable development, there is a critical lack of research on how localized configurations of marketing and policy factors shape ecolodge performance at the village level. This study addresses this gap by pioneering a comprehensive, contextually grounded analysis of the availability and desirability of key marketing and poli

Use of point-of-care tests in pharyngotonsillitis–a registry-based study in primary health care

Background: Point-of-care (POC) tests, including C-reactive protein (CRP) tests and rapid antigen detection tests (RADT) for group A streptococci (GAS), are widely used in Swedish primary health care (PHC). This study quantifies their use in pharyngotonsillitis and explore their association with antibiotic prescribing. Material and methods: Retrospective data from 2012–2016 in Region Kronoberg, Sw

Long-term clinical outcomes and prognosis

This chapter presents the long-term clinical outcomes and prognosis of COVID-19. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered a global pandemic infecting over 773 million people and causing over seven million deaths worldwide as of December 2023 (WHO Coronavirus). Despite the United Nations proclaimed the coronavirus disease 19 (COVID-19) pandemic officially over on M

The Potential of Hydrogeodesy to Address Water-Related and Sustainability Challenges

Increasing climatic and human pressures are changing the world's water resources and hydrological processes at unprecedented rates. Understanding these changes requires comprehensive monitoring of water resources. Hydrogeodesy, the science that measures the Earth's solid and aquatic surfaces, gravity field, and their changes over time, delivers a range of novel monitoring tools that are complement

First dose of misoprostol administration at home or in hospital for medical abortion between 12–22 gestational weeks in Sweden (PRIMA) : a multicentre, open-label, randomised controlled trial

Background: Medical abortion after 12 gestational weeks often requires a stay in hospital. We hypothesised that administering the first misoprostol dose at home could increase day-care procedures as compared with overnight care procedures, shorten inpatient stays, and improve patient satisfaction. Methods: This multicentre, open-label, randomised controlled trial was done at six hospitals in Swede

“Everyone decided to declare war on the forest”: between territorial peace and pacification in the Colombian Andean-Amazon

In post-peace agreement Colombia, everyone declared war on the forest. In the Putumayo region, these wars take their own particular forms. Scientifically, the Putumayo is described as an Andean-Amazonic rainforest. For the indigenous and local inhabitants of the Putumayo, it is the Andean-Amazonic selva. We present three wars on the forest with material and discursive specificities and critically

Microglia undergo disease-associated transcriptional activation and CX3C motif chemokine receptor 1 expression regulates neurogenesis in the aged brain

Adult neurogenesis continues throughout life but declines dramatically with age and in neurodegenerative disorders such as Alzheimer's disease. In parallel, microglia become activated resulting in chronic inflammation in the aged brain. A unique type of microglia, suggested to support neurogenesis, exists in the subventricular zone (SVZ), but little is known how they are affected by aging. We anal

Profiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney Disease

Diabetic kidney disease (DKD) is the leading cause of end stage kidney failure worldwide, of which cellular insulin resistance is a major driver. Here, we study key human kidney cell types implicated in DKD (podocytes, glomerular endothelial, mesangial and proximal tubular cells) in insulin sensitive and resistant conditions, and perform simultaneous transcriptomics and proteomics for integrated a

Surgery Combined with Local Implantation of Doxorubicin-Functionalized Hydroxyapatite Halts Tumor Growth and Prevents Bone Destruction in an Aggressive Osteosarcoma

Osteosarcoma treatment comprises pre-surgical chemotherapy followed by radical surgery and further chemotherapy cycles, but the prognosis has been far from satisfactory. No new drugs or treatment modalities have been developed for clinical use in the last four decades. We describe a nano-hydroxyapatite (HA)-based local drug delivery platform for the delivery of doxorubicin (DOX), a cornerstone dru