We demonstrate the extent to which modern detector technology, coupled with a high flux constant wavelength neutron source, can be used to obtain high quality diffraction data from short data collections, allowing the refinement of the full structures (including hydrogen positions) of hydrous compounds from in situ neutron powder diffraction measurements. The in situ thermodiffractometry and contr

Prostate-specific antigen (PSA or kallikrein-related peptidase-3, KLK3) exerts chymotrypsin-like proteolytic activity. The main biological function of PSA is the liquefaction of the clot formed after ejaculation by cleavage of semenogelins I and II in seminal fluid. PSA also cleaves several other substrates, which may explain its putative functions in prostate cancer and its antiangiogenic activit

The present work is based on the Kantian (AaO)-axiom and conceptualised as textbook. As scientific method in the true sense of the notion science, the Vertex version of Perspective Text Analysis represents a completely new approach to text-based studies. The core of Vertex is introduced by means of instructions to a stepwise procedure. The steps are richly illustrated. The inter-lingual character

Abstract in UndeterminedOn millennial or even centennial time scales, the activity of rapid flowing ice can affect climate variability and global sea level through release of meltwater into the ocean and positive feedback loops to the climate system. At the surge-type glacier Bruarjokull, an outlet of the Vatnajokull ice cap, eastern Iceland, extremely rapid ice flow was sustained by overpressuriz

In this review holographic interferometry and electron speckle pattern interferometry are discussed as efficient techniques for diffusion measurements in biochemical and pharmaceutical applications. Transport phenomena can be studied, quantitatively and qualitatively, in gels, liquids and membranes. Detailed information on these phenomena is required to design effective chromatography bioseparatio

A subset of populations of the European taxa of Carex sect. Digitatae, including Carex digitata, C. pallens, C. ornithopoda, C. pediformis ssp. rhizodes and C. humilis have been investigated for allozyme variation. The (presumably) distantly related C. pendula was used a's a reference taxon. Carex digitata, C. pallens and C. ornithopoda on the one hand, and C. humilis and C. pediformis on the othe

The aim was to study the outcome of Basic Body Awareness Therapy (Basic BAT) added to treatment as usual (TAU) compared to TAU only, for patients with mood, somatoform or personality disorders in psychiatric outpatient services. Seventy-seven patients were randomized to Basic BAT and TAU (n=38) or TAU only (n=39). Patients were assessed at baseline and after 12 sessions of Basic BAT, 3 months afte

Previous studies have suggested that amplification of genes, notably the TOP2A gene, on chromosome arm 17q may be important for the development of malignant peripheral nerve sheath tumour (MPNST). In order to study the frequency, distribution, and chromosomal organization of rearrangements at 17q, interphase and metaphase fluorescence in situ hybridization (FISH) were used to evaluate copy number

A shear-enhanced, cross-flow ultrafiltration module was used to separate cells and proteins from the fermentation broth. Three (fermented) media were studied: rich medium, rich medium with hydrolytic enzymes added after fermentation, and wheat flour hydrolysate. To find a membrane with as high a flux as possible, but still capable of separating cells and proteins from the lactic acid containing br

In this study, a potentiometric glucose biosensor was fabricated by immobilization of glucose oxidase on to zinc oxide nanowires. Zinc oxide nanowires with 250-300 nm diameters and approximately 1.2 mu m lengths were grown on the surface of silver wires with a diameter of 250 mu m. Glucose oxidase (GOD) was electrostatically immobilized on the surface of the well aligned zinc oxide nanowires resul

Interventions enabling aging individuals to fulfill their plastic potential promise to postpone, attenuate, or even reverse the adverse effects of senescent brain changes on cognitive abilities and everyday competence in old age. Based on an overview of the concept of plasticity in lifespan development, we selectively review evidence from cognitive intervention studies and conclude that most of th

Prostate cancer is one of the most frequent cancers in males in Western countries. Radical prostatectomy serves as the first line of treatment for patients with localised prostate cancer. However, in many cases the cancer will recur. It is currently difficult to identify those patients at a high risk of tumour recurrence. Therefore, molecular markers associated with and predicting disease recurren

Mutations in the CETP gene resulting in defective CETP activity have been shown to cause remarkable elevations of plasma HDL-C levels, with the accumulation in plasma of large, buoyant HDL particles enriched in apolipoprotein E. Genetic CETP deficiency thus represents a unique tool to evaluate how structural alterations of HDL impact on HDL atheroprotective functions. Aim of the present study was

OBJECTIVE: To estimate the accuracy of endometrial thickness measurement in the detection of endometrial cancer among women with postmenopausal bleeding with individual patient data using different meta-analytic strategies. DATA SOURCES: Original data sets of studies detected after reviewing the included studies of three previous reviews on this subject. An additional literature search of publishe

Background Clinical classification of rare sequence changes identified in the breast cancer susceptibility genes BRCA1 and BRCA2 is essential for appropriate genetic counselling of individuals carrying these variants. We previously showed that variant BRCA1 c.5096G>A p.Arg1699Gln in the BRCA1 transcriptional transactivation domain demonstrated equivocal results from a series of functional assays,

Popular Abstract in Swedish Bakgrund Med stigande ålder ökar antalet kroniska sjukdomar hos patienten och därmed även mängden läkemedel. I grunden är läkemedel bra produkter som lindrar, botar eller förebygger sjukdomar och lidande. Dock är äldre (>65 år) mer utsatta för potentiellt negativa effekter av läkemedel. Äldre personer använder många läkemedel, i synnerhet gäller det de äldre som bor påIntroduction: Older patients’ knowledge about their medicines is generally poor. Patients are entitled to be informed on an individual and adequate level. Evidence-based guidelines should, in most cases, be followed also in the treatment of elderly to avoid suboptimal treatment, for example for cardiovascular conditions, or risky prescriptions in the case of renal impairment. Objectives: 1. To de

The objective of this paper is to give an overview of some recently developed sum rules and physical bounds in scattering and antenna theory. The sum rules are based on integral identities for Herglotz functions that relate the quantity of interest with its low and high-frequency behavior. The sum rules are transformed to bounds by estimating the integrals and applying variational results to the p

This paper elucidates the increased need of correct calculations of thermal bridges for low/near zero energy buildings. The variability of the results from calculations of transmission losses for a building can be large if the calculation method within EN ISO 13789:2007 is not fully understood. A survey has been carried out which shows that there are no consensus in Sweden regarding how to define