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Background and Objectives. Thalidomide modulates the production of tumor necrosis factor (TNF-alpha). Soluble TNF receptors, TNFR p55 and TNFR p75, modify TNF-a activity. In this study, we explored the relation between soluble TNF receptors and outcome in patients with advanced multiple myeloma treated with thalidomide. Design and Methods. The levels of soluble TNF receptor p55 and p75 were assess

The article is devoted to investigation of classes of functions monotone as functions on general C-*-algebras that are not necessarily the C-*-algebra of all bounded linear operators on a Hilbert space as in classical case of matrix and operator monotone functions. We show that for general C-*-algebras the classes of monotone functions coincide with the standard classes of matrix and operator mono

Denna litteraturstudie utgör första etappen i ett licentiatarbete om utbytbarhet, material- och energiflöden för installationer i byggnader (Orsaker till byte av VVS-installationer; TABK--01/1020).

This thesis documented lake-level changes across Eurasia and made reconstructions of regional climates and atmospheric circulation patterns during the late Quaternary; analysed temporal signals in lake record; used lake data to improve pollen-based quantitative recostructions of climate; and compared lake data with simulated P-E fields from Atmospheric General Circulation (AGC) models. Lake record

Abstract is not available.

Popular Abstract in Swedish Alzheimers sjukdom och vaskulär demens är de vanligaste orsakerna till demens hos äldre, ett tillstånd som i takt med den ökande åldrade befolkningen kommer att innebära ett allt större lidande och en alltjämt ökande ekonomisk belastning. Direkta och indirekta kostnader för vård och omsorg av demenspatienter uppgår sannolikt till ca 40 miljarder kronor om året. Detta ärDementia is a state of permanent loss of cognitive function, most commonly affecting the elderly. With a rapidly growing aged population, the spectrum of disorders that lead to dementia is exerting an ever-increasing toll on patients, families and society alike. The most common dementing disorders are Alzheimer's disease and vascular dementia. Although Alzheimer's disease is very common and was de

To assess the age-related loss of muscle mass and to determine the mechanisms behind this aging atrophy, the muscle structure and fiber type composition have been estimated, using invasive and noninvasive techniques. Limb muscles from older men and women are 25-35% smaller and have significantly more fat and connective tissue than limb muscles from younger individuals. Comparisons of muscle biopsi

This paper presents a new relationship between the roughness height and the main hydrodynamic and sediment parameters for plane beds under steady current conditions. In order to derive such a formula, a large data base involving plane-bed experiments was compiled from previous investigations and analyzed. Comparisons between the data and different existing predictive formulas for the bed roughness

Caloplaca gyalectoides S. Kondratyuk & Karnefelt from the Cape Province, South Africa, and Caloplaca chilensis S. Kondratyuk, Karnefelt, Froden & Arup with an associated parasymbiont Arthonia tetraspora S. Kondratyuk & Karnefelt occurring mainly along the coast in central Chile are described as new. Possible associated taxa are briefly discussed. Distribution maps are provided for all

Background: The molecular genetics of the P blood group system and the absence of P1 antigen in the p phenotype are still enigmatic. One theory proposes that the same gene encodes for both the P1 and P-k glycosyltransferases, but no polymorphisms in the coding region of the P-k gene explain the P-1/P-2 phenotypes. We investigated the potential regulatory regions up- and downstream of the A4GALT (P

The effects on wood of simultaneous mechanical and moisture loading are studied. In order to clarify the mechano-sorptive behaviour of wood, a review of different phenomena presented in the literature is included. Compressive tests have been performed on spruce. The tests have been performed with both constant load and varying load. The humidity has been varied during the tests. The properties of

[abstract missing]

We have identified a new cyclic-nucleotide phosphodiesterase isoform, PDE3A, and cloned its cDNA from cultured aortic myocytes. The nucleotide sequence of its coding region is similar to that of the previously cloned myocardial isoform except for the absence of the initial 300-400 nt that are present in the latter, as confirmed by reverse-transcriptase-mediated PCR, 5' rapid amplification of cDNA

Sedan våren 2005 har en grupp tonåriga pojkar inom habiliteringen i Region Skåne engagerats i en till synes udda fritidsaktivitet. Tillsammans med medlemmar i en motorförening och en fritidsförening samlas de en kväll i veckan på en motorgård i Väla utanför Helsingborg för att meka med en gammal bil. ”Projekt Raggarbil” har på kort tid blivit mycket populärt bland ungdomarna, deras föräldrar och

1. Stocking of piscivores in shallow, eutrophicated lakes to reduce cyprinid densities is a common approach in lake restorations. Young-of-the-year (YOY) pike Esox lucius are frequently used to reduce cyprinid densities, but their effectiveness is equivocal. This study uses a simple model to assess the efficacy of pike stocking as a lake restoration tool. 2. The model evaluates YOY pike consumptio

Cell culture models were used to study the effects of long-term ethanol exposure on neuronal cells. Effects on phospholipase C and phospholipase D mediated signal transduction were investigated by assaying receptor-binding, G protein function, activities of lipases, formation of second messengers and c-fos mRNA. The signal transduction cascades displayed abnormal activities from 2 to 7 days of exp