Predictive information and maintenance optimization for deteriorating structures is concerned with scheduling (a) the collection of information by inspection and monitoring and (b) maintenance actions such as repair, replacement, and retrofitting based on updated predictions of the future condition of the structural system. In this article, we consider the problem of jointly identifying—at the beg

Although science has been a formidably successful force of social and technological development in the modern era, and a main reason for the wealth and well-being of current societies compared to previous times, a fundamental distrust characterizes its current status in society. According to prevalent discourse, science is insufficiently productive and in need of stricter governance and bureaucrat

The institution of science is said to be under pressure from political, economic and social interests, manifested in alleged bureaucratization, managerial reforms, anti-intellectual movements on university campuses, and widespread questioning of expert knowledge in society. Commercialization of academic publishing and the growth of competitive funding have increased the importance of journal and g

Background: The mechanism of synaptic loss in Alzheimer’s disease is poorly understood and may be associated with tau pathology. In this combined positron emission tomography (PET) and magnetoencephalography (MEG) study, we aimed to investigate spatial associations between regional tau pathology ([18F]flortaucipir PET), synaptic density (synaptic vesicle 2A [11C]UCB-J PET) and synaptic function (M

Structure liming aims to improve soil structure (i.e., the spatial arrangement of particles and pores) and its stability against external and internal forces. Effects of lime application on soil structure have received considerable interest, but only a few studies have investigated effects on macro- and mesopore networks. We used X-ray computed tomography to image macropore networks (ø ≥ 0.3 mm) i

Nanosized spherical copper particle embedded on oxide matrix (Cunp-Cu2O/SiO2) is synthesized from a low cost chalcopyrite concentrate. The concentrate is reduced by hydrogen at 1323 K, followed by acid leaching to produce Cunp-Cu2O/SiO2. Powder X-ray diffraction confirms the formation of metallic copper as the principal phase along with oxides of silicon and copper. The weight fractions of Cu, SiO

Study region: Sixty-four river gauging stations distributed over Sweden. Study focus: To investigate the influence of climate teleconnection patterns (TP) on streamflow in Sweden. Streamflow data is regionalized and the average hydrographs of each homogeneous region is divided into hydrological seasons. Thereafter the impact of different TPs on the streamflow, per homogeneous region and per hydrol

Anthropogenic nitrogen (N) enrichment in boreal forests has been shown to enhance aboveground net primary production and downregulate soil respiration, but it is not well understood if these effects are driven by reduced belowground C allocation or shifts between biomass production and respiration in fine-roots and ectomycorrhizal fungi (EMF). We utilized an experiment in a Pinus sylvestris (L.) f

PICT (Pollution Induced Community Tolerance) to Cu is a useful and sensitive tool to assess the effects of Cu pollution in soils under laboratory conditions. However, in field situations, the absence of reference values, i.e. bacterial community tolerance to Cu baseline from non-polluted soils, make the method uncertain when we want to know if a soil is or is not polluted from a microbiological po

Our understanding of the early Cambrian bioradiation is largely driven by the contrasting information obtained from small skeletal fossils (SSF) and various types of exceptionally preserved fossils from different parts of the world. In this study, a new ‘Orsten’-type fossil Lagerstätte is reported from the Cambrian Series 2 upper Shuijingtuo Formation in the eastern Three Gorges area, South China.

Most developments in regenerative medicine have in common that there are many uncertainties and knowledge gaps. These features make the evaluation of long-term consequences of the available options difficult and have consequences for the ethical issues raised. This paper presents an overview of ethical issues raised in regenerative medicine, using as a starting point a list of stakeholders and theMost developments in regenerative medicine have in common that there are many uncertainties and knowledge gaps. These features make the evaluation of long-term consequences of the available options difficult and have consequences for the ethical issues raised. This paper presents an overview of ethical issues raised in regenerative medicine, using as a starting point a list of stakeholders and the

Bull fertility is an important trait in breeding as the semen of one bull can, potentially, be used to perform thousands of inseminations. The high number of inseminations needed to obtain reliable measures from Non-Return Rates to oestrus creates difficulties in assessing fertility accurately. Improving molecular knowledge of seminal properties may provide ways to facilitate selection of bulls wi

Bracko has commented on our paper ‘forces on hockey players: vectors, work, energy and angular momentum’and refers to extensive studies on skaters using traditional techniques. We note that results based on one skating technique, such as a correlation between stride rate and speed, cannot be immediately applied to a different technique.

Many metabolic pathways, including lipid metabolism, are rewired in tumors to support energy and biomass production and to allow adaptation to stressful environments. Neuroblastoma is the second deadliest solid tumor in children. Genetic aberrations, as the amplification of the MYCN-oncogene, correlate strongly with disease progression. Yet, there are only a few molecular targets successfully expl