Sökresultat

Human carbonic anhydrases (hCAs) play various roles in cells, and have been drug targets for decades. Sequence similarities of hCA isoforms necessitate designing specific inhibitors, which requires detailed structural information for hCA-inhibitor complexes. We present room temperature neutron structures of hCA II in complex with three clinical drugs that provide in-depth analysis of drug binding,

The structural investigation of cellular membranes requires access to model systems where the molecular complexity is representative of the cellular environment and that allow for the exploitation of structural techniques. Neutron scattering, and in particular neutron diffraction can provide unique and detailed information on the structure of lipid membranes. However, deuterated samples are desira

The economic literature on migration has a strong focus on labor migration. It typically distinguishes between migration within countries and between countries and it focuses on the determinants of migration rather than their consequences. Motives and consequences of migration are difficult to separate. We explore the policy implications and empirical support of six common theories. We distinguish

Aims and objectives: The aim of this study was to explore the associations between patients' gender, education, health status in relation to assessments of patient-centred quality and individuality in care and trust in nurses for those <65 (working age) and ≥65 years (older people). Background: Patients' assessments of the quality of care they receive are essential for the development of the provi

We explore time-resolved Coulomb explosion induced by intense, extreme ultraviolet (XUV) femtosecond pulses from a free-electron laser as a method to image photo-induced molecular dynamics in two molecules, iodomethane and 2,6-difluoroiodobenzene. At an excitation wavelength of 267 nm, the dominant reaction pathway in both molecules is neutral dissociation via cleavage of the carbon-iodine bond. T

Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses proton-proton collision data corresponding to an integrated luminosity of 36.1 fb−1 at a centre-of-mass energy of 13 TeV collected in 2015 and 2016 with the ATLAS detector at the Large Hadron Collider. Events are required to have at least one jet with a tr

A search for heavy neutral Higgs bosons and Z′ bosons is performed using a data sample corresponding to an integrated luminosity of 36.1 fb−1 from proton-proton collisions at s=13 TeV recorded by the ATLAS detector at the LHC during 2015 and 2016. The heavy resonance is assumed to decay to τ+τ− with at least one tau lepton decaying to final states with hadrons and a neutrino. The search is perform

In this paper we present new techniques for constructing compact and robust minimal solvers for absolute pose estimation. We focus on the P4Pfr problem, but the methods we propose are applicable to a more general setting. Previous approaches to P4Pfr suffer from artificial degeneracies which come from their formulation and not the geometry of the original problem. In this paper we show how to avoi

This paper considers the problem of recovering either a low rank matrix or a sparse vector from observations of linear combinations of the vector or matrix elements. Recent methods replace the non-convex regularization with ℓ1 or nuclear norm relaxations. It is well known that this approach recovers near optimal solutions if a so called restricted isometry property (RIP) holds. On the other hand i

The results of a search for squarks and gluinos in final states with an isolated electron or muon, multiple jets and large missing transverse momentum using proton-proton collision data at a center-of-mass energy of √ = 13 TeV are presented. The data set used was recorded during 2015 and 2016 by the ATLAS experiment at the Large Hadron Collider and corresponds to an integrated luminosity of 36.1 f

A scheme for exploiting cooperation in satellite receivers is proposed. The cooperation takes place through a capacity-constrained link, and we assume that a relay node quantizes its received signal and sends it to the destination node. We demonstrate its effectiveness with three different schemes on satellite channels with high-order APSK modulations. The first two schemes employ equidistant quan

In this paper, we present a time-recursive implementation of a recent hyperparameter-free group-sparse estimation technique. This is achieved by reformulating the original method, termed group-SPICE, as a square-root group-LASSO with a suitable regularization level, for which a time-recursive implementation is derived. Using a proximal gradient step for lowering the computational cost, the propose

We consider the over-fitting problem for multinomial probabilistic Latent Semantic Analysis (pLSA) in collaborative filtering, using a regularization approach. For big data applications, the computational complexity is at a premium and we, therefore, consider a maximum a posteriori approach based on conjugate priors that ensure that complexity of each step remains the same as compared to the un-re

Objective: The aim was to evaluate surgical routes for benign hysterectomy in a Swedish population, including abdominal and minimally invasive surgery. Study design: Prospectively collected data from the Swedish National GynOp Registry 2009–2015: 13 806 hysterectomy cases were included: abdominal (AH, n = 7485), vaginal (VH, n = 3767), conventional laparoscopic (LH, n = 1539) and robotically-assis

This synopsis covers evidence for the effects of conservation interventions for native farmland wildlife. It is restricted to evidence captured on the website www.conservationevidence.com. It includes papers published in the journal Conservation Evidence, evidence summarized on our database and systematic reviews collated by the Collaboration for Environmental Evidence. It is the thrid volume in t

The weaving together of fragments under the heading of a “weak” theme has a long tradition in research. The strategy has, however, not been so popular after the 19th century, even though advocates of a more modern fragmentology can be found, e.g. in Walter Benjamin. For Benjamin, the artefacts truly showed themselves only when the context had disappeared or been forgotten. In this article we would