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On the Effectiveness of Loan-to-Value Regulation in a Multiconstraint Framework

Models in the infinite horizon macro-housing literature often assume that borrowers are constrained exclusively by the loan-to-value (LTV) ratio. Motivated by the Swedish microdata, I explore an alternative arrangement where borrowers are constrained by a collateral constraint and by a debt-service-to-income ratio. While stricter LTV limits are often considered as a measure to tackle the rise in h

Diurnal variations in the quality of stroke care in Sweden

Objectives: A recent study of acute stroke patients in England and Wales revealed several patterns of temporal variation in quality of care. We hypothesized that similar patterns would be present in Sweden and aimed to describe these patterns. Additionally, we aimed to investigate whether hospital type conferred resilience against temporal variation. Materials and Methods: We conducted this nation

Occupational exposure to organic particles and combustion products during pregnancy and birth outcome in a nationwide cohort study in Sweden

Objective: To study if children of women exposed to organic particles and combustion products at work during pregnancy, have an increased risk of low birth weight, preterm birth or small for gestational age. Methods: A nationwide cohort of all occupationally active mothers and their children from single births during 1994 to the end of 2012 (1 182 138 observations) was formed. Information on birth

Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers

INTRODUCTION: More than 70 common alleles are known to be involved in breast cancer (BC) susceptibility, and several exhibit significant heterogeneity in their associations with different BC subtypes. Although there are differences in the association patterns between BRCA1 and BRCA2 mutation carriers and the general population for several loci, no study has comprehensively evaluated the associatio

A diagnosis of rheumatoid arthritis, endometriosis or IBD is associated with later onset of fibromyalgia and chronic widespread pain

BACKGROUND: Widespread pain is a common comorbidity in several chronic diseases and is suspected to be caused by the underlying disease that has provoked a state of central sensitization. However, this argument is currently limited by evidence that has not sufficiently captured the temporal nature of the relationship between diagnosis of the underlying disease and onset of widespread pain. The aim

The age of the Middle Ordovician Winneshiek Shale : reply to a critical review by Lindskog & Young (2019) of a paper by Bergström et al. (2018a)

A recent review by Lindskog & Young (2019) of a paper published in Lethaia by Bergström et al. (2018a) contains many errors, misleading statements and unsupported opinions. Their review claims that we did not consider biostratigraphy in our efforts to chemostratigraphically date the Winneshiek Shale. That this is incorrect is shown by the fact that Liu et al. (2017), which contains a two-page

Community Currencies as Means of Local Economic Empowerment : Innovations from Mombasa and Nairobi to Kisumu, Kenya

Community currencies have emerged as a tool for building more inclusive local economic development and governance. Grassroots organisations in Nairobi and Mombasa (Kenya) have been experimenting with this form of local monies. Communities in informal settlements in Kisumu have shown interest in introducing their own community currency. Challenges remain concerning the best diffusion strategy of su

A performative view of language : Methodological considerations and consequences for the study of culture

Although researchers across the social sciences speak of a linguistic turn, most research exploring culture still assumes a traditional perspective on language, which conceives meaning as representation. Yet, Wittgenstein convincingly criticized the epistemological basis of such a perspective, offering an alternative view on language. The paper begins by explaining the central points of a performa

Obesutten och osynliggjord : En betraktelse över historisk arkeologi på marginalen

In the 19th and early 20th centuries there were numerous non-proprietors paupers in the Swedish countryside such as crofters, boarders and inhabitants of rural slums. With a change in the heritage legislation, increased possibilities to archaeologically investigate the non-proprietors of the recent past have emerged, but the archaeological material is still both scarce and of a repetitive characteIn the 19th and early 20th centuries there were numerous non proprietor, poor and pauper people in the Swedish countryside such as crofters, boarders and inhabitants of rural slums. With a change in the heritage legislation, increased possibilities to archaeologically investigate the non proprietors of the recent past has emerged, however the archaeological material is still both scarce and of a r

Automatic detection of small areas of Gleason grade 5 in prostate tissue using CNN

There are several different approaches used to treat prostate cancer, depending on age and general health conditions of the patient but also how severe the cancer is. To determine the latter, Gleason grading is used. The grade is determined by a pathologist, based on structures in histology samples from prostate biopsies. To determine the diagnosis, both the most common Gleason grade but also the

WISC-III index score profiles of 520 Swedish children with pervasive developmental disorders

WISC-III (Wechsler, 1991) index score profiles and their characteristics were examined with traditional statistics in a large Swedish sample consisting of children with autistic disorder (n = 85), Asperger's disorder (n = 341), or pervasive developmental disorders not otherwise specified (PDD-NOS; n = 94). There was a clear and significant difference in level between children with Asperger's disor

Accurate Orbital Solution for the New and Metal-poor Eclipsing Binary Tycho 5227-1023-1

The orbit and physical parameters of the previously unsolved double-lined eclipsing binary Tyc 5227-1023-1, discovered during the search for RR Lyr variable candidate members of the Aquarius stream, are derived using high-resolution chelle spectroscopy and V, i' photometry. A synthetic spectral analysis of both components has been performed, yielding metallicity [M/H] =-0.63± 0.11 for both stars a

The K2-HERMES Survey. I. Planet-candidate Properties from K2 Campaigns 1-3

Accurate and precise radius estimates of transiting exoplanets are critical for understanding their compositions and formation mechanisms. To know the planet, we must know the host star in as much detail as possible. We present first results from the K2-HERMES project, which uses the HERMES multi-object spectrograph on the Anglo-Australian Telescope to obtain R ∼ 28000 spectra of up to 360 stars i

Non-negative least squares fitting of multi-exponential T2 decay data: Are we able to accurately measure the fraction of myelin water?

The ability to determine the myelin water fraction (MWF) in vivo is essential to assessments of neurodevelopmental myelination and myelin damage in neurodegenerative diseases. The analysis of multi-exponential T2 decay data relies on the non-negative-least-squares (NNLS) fitting, which may be sensitive to the chosen fitting parameters. We performed simulations to explore the outcomes of NNLS under

Using MODIS derived fPAR with ground based flux tower measurements to derive the light use efficiency for two Canadian peatlands

We used satellite remote sensing data; fractionof photosynthetically active radiation absorbed by vegetation(fPAR) from the Moderate Resolution Imaging Spectrora-diometer (MODIS) in combination with tower eddy covari-ance and meteorological measurements to characterise theLight Use Efficiency parameter (ε)variability and the maxi-mumε(εmax)for two contrasting Canadian peatlands. Eight-day MODISfPA

Chapter 40 - Lymphocyte Trafficking to Mucosal Tissues

Lymphocytes are the key cells of the adaptive immune system that provide antigen-specific responses tailored to the context of antigen exposure. Through cytokine release and antibody production, lymphocytes orchestrate and amplify the recruitment and function of other immune cells and contribute to host defense against invading pathogens and the pathogenesis of many inflammatory diseases. Lymphocy

Bacterial attachment to uro-epithelial cells : mechanisms and consequences.

Microbial attachment to mucosal surfaces is a first step in mucosal infection. Specific interactions between microbial surface ligands and host receptors influence the distribution of microbes in their sites of infection. Adhesion has often been regarded as a sufficient end point, explaining tissue tropism and bacterial persistence at mucosal sites. Adherence, however, is also a virulence factor t