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Structural analysis and thermodynamics of the ionotropic glutamate receptor GluA2 modulator BPAM-97

Ionotropic glutamate receptors are tetrameric ligand gated ion channels that mediate in ux and ef ux of metal ions in response to glutamate. Positive allosteric modulators of the ionotropic glutamate receptor 2 (GluA2) are promising lead compounds for drugs against cognitive disorders. These compounds bind within the dimeric interface formed by the receptor ligand binding domains (LBDs) attenuatin

The housing market in Sweden: a political-historical perspective

The price of housing in Sweden has, over the past couple of decades, increased at a much faster rate than salaries. Politicians have tried to steer the housing market towards the provision of affordable housing, but have not succeeded. After 1993, the responsibility for regulating the price of housing transferred to the market, which is more interested in building for high-income earners. Despite

Psychometric properties of the original and short versions of the Falls Efficacy Scale-International (FES-I) in people with Parkinson's disease

Background: Fear of falling is common in people with Parkinson's disease (PD) and is associated with an increased risk for future falls, activity limitations and a reduced quality of life. The Falls Efficacy Scale-International (FES-I) assesses fear of falling conceptualized as concerns about falling. The original FES-I has good psychometric properties in people with PD, but whether this applies a

Epidemiology and causes of death in a Swedish cohort of patients with autoimmune hepatitis

Background: Epidemiological studies of autoimmune hepatitis (AIH) show varying figures on prevalence and incidence, and data on the long-term prognosis are scarce. Objective To investigate the epidemiology, long-term prognosis and causes of death in a Swedish AIH cohort. Material and methods: Data collected from 634 AIH patients were matched to the Cause of Death Registry, and survival analyses we

Evolution and forcing mechanisms of El Niño over the past 21,000 years

TheEl Niño SouthernOscillation(ENSO) isEarth's dominant source of interannual climate variability, but its response to globalwarming remainshighly uncertain1.To improve ourunder standing of ENSO's sensitivity to external climate forcing, it is paramount to determine its past behaviour by using palaeoclimate data and model simulations. Palaeoclimate records show that ENSO has varied considerably si

Close to the edge: growth restrained by the NAD(P)H/ATP formation flux ratio

Most fermentative microorganisms grow well-under anaerobic conditions managing a balanced redox and appropriate energy metabolism, but a few species do exist in which cells have to cope with inadequate energy recovery or capture and/or redox balancing. Two cases of these species, i.e., the metabolically engineered Saccharomyces cerevisiae enabling it to ferment xylose and Lactobacillus reuteri fer