Alpha1-microglobulin (alpha1m) is an electrophoretically heterogeneous plasma protein. It belongs to the lipocalin superfamily, a group of proteins with a three-dimensional (3D) structure that forms an internal hydrophobic ligand-binding pocket. Alpha1m carries a covalently linked unidentified chromophore that gives the protein a characteristic brown color and extremely heterogeneous optical prope

cDNA coding for alpha 1-microglobulin, an immunoregulatory plasmaprotein, was isolated from bovine liver. The sequence of a total of 1258 nucleotides revealed an open reading frame of 352 amino acids. This included alpha 1-microglobulin, 182 amino acids, and bikunin, the light chain of the plasmaprotein inter-alpha-inhibitor, 147 amino acids. The two proteins were connected by a basic tetrapeptide

Most group A streptococcal strains bind immunoglobulins (Ig) and fibrinogen to their cell walls. It is shown in this paper that the Ig-binding of three different strains was much weaker at 37 degrees C than at room temperature (20 degrees C), whereas the fibrinogen binding was unaffected by temperature. The binding properties and molecular sizes of two purified group A streptococcal cell surface p

alpha 1-Microglobulin is an immunosuppressive plasma protein synthesized by the liver. The isolated protein is yellow-brown, but the hypothetical chromophore has not yet been identified. In this work, it is shown that a human liver cell line, HepG2, grown in a completely synthetic and serum-free medium, secretes alpha 1-microglobulin which is also yellow-brown, suggesting a de novo synthesis of th

The precursor protein alpha 1-microglobulin-bikunin was cleaved to the same degree whether expressed in CHO cells or in mutated CHO cells, RPE.40 cells, suggested to lack a functional form of the intracellular protease furin. Thus, alpha 1-microglobulin-bikunin probably is not cleaved in vivo by furin. However, simultaneous overexpression of the precursor and furin in COS, CHO and RPE.40 cells inc

Two nitrifying MBBR reactors were operated in parallel, one with PAC dosing and one without, to determine the effects of PAC dosing on nitrification and micropollutant adsorption in municipal wastewater. The removal of micropollutants was evaluated for several doses of PAC and batch experiments were performed to measure adsorption kinetics and nitrification rates. The influence of PAC on the nitri

Introduction: The Visual Ergonomics Risk Assessment Method (VERAM) is a newly developed and validated method to assess visual ergonomics at workplaces. VERAM consists of a questionnaire and an objective evaluation. Objective: To evaluate reliability of VERAM by assessing test-retest reliability of the questionnaire, and intra- and inter-rater reliability of the objective evaluation. Methods: Forty

A measurement of the production of prompt Λ c + baryons in Pb–Pb collisions at s NN =5.02 TeV with the ALICE detector at the LHC is reported. The Λ c + and Λ‾ c − were reconstructed at midrapidity (|y|

INTRODUCTION: Standard treatment of congenital haemophilia A is based on replacement therapy with coagulation factor VIII (FVIII) products. A major complication of FVIII therapy is the occurrence of IgG alloantibodies (inhibitors) that neutralize FVIII activity.AIM: The aim of the analysis was estimating the risk of high-titre inhibitor associated with the second-generation full-length product com

Rationale: Smoking is a primary risk factor for chronic bronchitis, emphysema, and chronic obstructive pulmonary disease, but since not all smokers develop disease, it has been suggested that some individuals may be more susceptible to exogenous factors, such as smoking, and that this susceptibility could be genetically determined. Objectives: The aim of the present study was to assess, in a popul

Lexical frequency effects on word accent processing in SwedishSeveral studies have investigated the neurophysiological underpinnings of the Swedish word accents, “accent 1” and “accent 2” ([1]-[5]), which are known to have a strong association with morphology ([6]-[8]). For example, if the singular noun suffix -en is attached to the word stem bil (‘car’), the resulting word is bil1-en (‘the car’)

The broad utilisation of imidacloprid (IMI)in agriculture poses an increasing risk to aquatic organisms. However, the potential impacts on commercially important shellfish and chemical residues after exposure, are yet to be assessed. We investigated the levels of IMI in Sydney rock oyster (SRO)tissue during a three-day uptake and four-day depuration cycle using liquid chromatography-mass spectrome

From the 1880s until the ban of this practice in the 1970s, German vacationers built sandcastles, some of which were artfully decorated and awarded prizes in competitions by the spa administrations. Research regards this as a manifestation of a ‘typical German’ national character. The article counters this approach with an interpretation that understands sandcastles as metaphors for typical charac

We have measured the lattice size dependence of the lightest glueball mass in SU(2) and SU(3) gauge theory at =2.2 and 2.3 [SU(2)] and =6.0 [SU(3)]. We observe an increase in the glueball mass when the lattice size shrinks below a critical value. The magnitude of this length scale, which we interpret as the physical size of the glueball, is roughly the same for SU(2) and SU(3) when expressed in un

The static potentials from bosonic string models are examined to the two-loop level. Available MC data for 4-dimensional SU(3) are in approximate agreement with the universal leading order predictions but fail to reproduce the Nambu string when the two-loop terms are included in the analysis. We also confront Nambu string model predictions for Tc σ with SU(2), SU(3) and SU(N → ∞) MC data. In the S

We study 3-dimensional SU(2) lattice gauge theory with respect to dimensional reduction. By Monte Carlo calculations we find that this reduction is valid to a good approximation (within ≈10%). The adjoint string tension is found to scale approximately. We also compare the adjoint string tension with a string theory.