Chronic myeloid leukemia (CML) stem cells appear resistant to tyrosine kinase inhibitors (TKIs) in vitro, but their impact and drug sensitivity in vivo has not been systematically assessed. We prospectively analyzed the proportion of Philadelphia chromosome-positive leukemic stem cells (LSCs, Ph+CD34+CD38=) and progenitor cells (LPCs, Ph+CD34+CD38+) from 46 newly diagnosed CML patients both at the

In experimentally induced myocardial ischemia, mild hypothermia (33-35 degrees C) has a robust cardioprotective effect. Tissue plasminogen activator (t-PA) is a profibrinolytic enzyme that is released from the vascular endothelial cells in response to ischemia and other injurious stimuli. t-PA has also been found to have proinflammatory properties that could contribute to reperfusion injury. We po

Insect wing shapes are remarkably diverse and the combination of shape and kinematics determines both aerial capabilities and power requirements. However, the contribution of any specific morphological feature to performance is not known. Using targeted RNA interference to modify wing shape far beyond the natural variation found within the population of a single species, we show a direct effect on

Photon time-of-flight spectroscopy (PTOFS) is a powerful tool for analysis of turbid materials. We have constructed a time-of-flight spectrometer based on a supercontinuum fiber laser, acousto-optical tunable filtering, and an InP/InGaAsP microchannel plate photomultiplier tube. The system is capable of performing PTOFS up to 1400 nm, and thus covers an important region for vibrational spectroscop

Background: The 'Convention on the Rights of Persons with Disabilities' (CRPD) requires governments to meet the assistive technology needs of citizens. However, the access to assistive technology in developing countries is severely limited, which is aggravated by a lack of related services. Objectives: To summarize current knowledge on assistive technology for low- and lower-middle-income countrie

Plant functional response groups (PFGs) are now widely established as a tool to investigate plant-environment relationships. Different statistical methods to form PFGs are used in the literature. One way is to derive emergent groups by classifying species based on correlation of biological attributes and subjecting these groups to tests of response to environmental variables. Another way is to sea

alpha-Synuclein (alpha-Syn) accounts, as a major component of Lewy bodies (LB), for the filamentous deposits in many cases of neurodegenerative diseases. Yet, little is known about the molecular mechanisms of neuronal loss in these diseases. The correlation between alpha-Syn oligomerization/aggregation and pathologies raises the key question of which molecular form of alpha-Syn (i.e. monomeric alp

Orange is a tropical fruit used in the juice industry, yielding important quantities of by products. The objective of this work was to obtain a dietary fiber-rich orange bagasse product (DFROBP), evaluate its chemical composition and its use in the preparation of a bakery product (muffin). Muffins containing two different levels of DFROBP were studied regarding chemical composition, in vitro starc

Despite the wide diversity of available solar technologies, solar energy systems are still not considered as main stream technologies in building practice. This may be attributed to several factors such as lack of awareness and knowledge among architects, lack of tools supporting the design process, and lack of solar products designed for building integration. In order to address these issues, the

Despite its remarkable receptivity to immigrants entering the country, Sweden has one of the worst track records in Europe in terms of employing immigrants. However, although there are various studies devoted to integration issues, little scholarly attention has been directed toward public employment officers and their role as professional mediators in the integration process. By investigating the

The present article represents a quite literal take on the theme of the special issue of Australian Feminist Law Journal in which it appears by discussing the public park as a garden of justice: on the one hand a concrete, geographical setting in which law and morality become manifest, on the other hand the site of a more intangible space which is constituted by the struggles between different spa

Liquid fermentations of the fungus Stereum rameale (No 2511) yielded extracts with antibacterial -activity. The antibacterial activity reached its peak after 216 h of stirring. Bioassay-guided fractionation methods were employed for the isolation of the bioactive metabolites. Three known compounds were identified: MS-3 (1), vibralactone (2) and vibralactone B (3). The three compounds showed antiba

Lime–hemp concrete (LHC) is a sustainable building material that combines hemp shiv and building limes. Moisture fixation and thermal properties of LHC were determined so as to gain knowledge about the material’s behaviour in a cold, wet climate. Sorption isotherms were produced over the whole moisture range for two LHC mixes by means of glass jar tests and a pressure plate apparatus. Thermal prop