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The underlying cause of neuronal loss in Parkinson's disease (PD) remains unknown, but evidence implicates neuroinflammation in PD pathobiology. The pro-inflammatory cytokine soluble tumor necrosis factor (TNF) seems to play an important role and thus has been proposed as a therapeutic target for modulation of the neuroinflammatory processes in PD. In this regard, dominant-negative TNF (DN-TNF) ag

This article covers some of the findings of a pilot study of what we per-ceive to be a tendency towards a codification of the contemporary urban vernacular in written Swedish. In Sweden, the urban vernacular has tradi-tionally been described as a youth language, and, as such, studied as a part of an (ephemeral) youth culture. However, both internationally and in Sweden there are claims to treat th

Introduction: Self-monitoring of blood glucose (SMBG) is the standard of care for women with gestational diabetes mellitus (GDM). This study aimed to review SMBG profiles in women with GDM and to examine how glucose metrics derived from SMBG relate to fetal overgrowth and infants born large for gestational age (LGA, >90th percentile). Material and Methods: This was a single-center, historical, obs

Objective The aim of this study was to assess associations between endostatin levels and short-term mortality in unsorted acute hospitalised dyspnoea patients with or without congestive heart failure (CHF), adjusted for common cardiovascular risk factors.Design, setting and participants In this prospective observational study, 723 hospitalised patients who visited the emergency department at Skåne

RATIONALE: Preterm infants diagnosed with bronchopulmonary dysplasia (BPD) are thought to have fewer and larger alveoli than their term peers, but it is unclear to what degree this persists later in life.OBJECTIVES: To investigate to what degree the distal airspaces are enlarged in adolescents born preterm and to evaluate the new Airspace Dimension Assessment (AiDA) method in investigating this gr

This configurative review explores how nurturing and enacting a community-oriented praxis (COP) in teacher education can enhance teacher candidates’ preparedness for teaching roles whilst addressing some broader educational and societal concerns. Here, CoP is defined as practices that consider, connect with, and draw on local community strengths, needs, and aspirations for the good of individuals,

Although the literature widely discusses the role of academics as experts in public policy making, empirical case studies on ethical problems related to the production and implementation of health policy are scarce. During COVID-19, the Swedish policy document (PD) National Principles for Prioritization in Intensive Care under Extraordinary Conditions was produced in collaboration with 11 academic

In this article, I explore concerns that have been raised regarding the relation between love and uptake of reproductive technologies, embryo selection and enhancement. Objections to (certain) uses of these technologies in terms of fractures in love, either parental or between partners, come from a variety of directions, from the conservative to the liberal. I examine two claims: (1) that the sepa

Ojämlikhet, i termer av hur resurser fördelas mellan olika kategorier av människor, är ett genomgripande samhällsfenomen. Den svenska arbetsmarknaden är inget undantag och uppvisar en betydande grad av klassad, etnifierad och könad ojämlikhet när det gäller tillgång till kontroll och makt över produktionsförhållanden. Denna avhandling syftar till att bidra med kunskap om hur och varför ojämlikhetsInequality, in terms of how resources are distributed between different categories of people is a pervasive phenomenon in society. The Swedish labour market is no exception, exhibiting a significant degree of classed, ethnified and gendered inequality in terms of access to control and power over production conditions. This thesis aims to contribute knowledge about how and why inequality regimes ar

Trots att majoriteten av dem som dör av opioidöverdoser haft kontakt med sjukvård, socialtjänst eller kriminalvård, visar en ny analys att en stor grupp – nästan hälften – saknar betydande vårdkontakter kopplade till sina drogproblem. För att stärka det förebyggande arbetet mot överdoser behövs en förändring i vården, där lågtröskelinsatser kompletteras med bredare screening och mindre stigmatiserDespite the fact that the majority of those who die from opioid overdoses have been in contact with healthcare, social services, or the justice system, a new analysis shows that a large group – nearly half – lacks significant care connections related to their drug problems. To strengthen preventive efforts against overdoses, a change in care is needed, where low-threshold interventions are complem

European semi-natural grasslands are hotspots for biodiversity and important for the provisioning of multiple ecosystem services, but their extent has declined considerably during the past century. Increasing demands for agricultural and forest biomass risk causing further loss of grasslands, raising concern about a goal conflict between climate mitigation and biodiversity conservation. This study

The Gaia-ESO Survey is an European Southern Observatory (ESO) public spectroscopic survey that targeted 105 stars in the Milky Way covering the major populations of the disk, bulge and halo. The observations were made using FLAMES on the VLT obtaining both UVES high (R ~ 47 000) and GIRAFFE medium (R ~ 20 000) resolution spectra. The analysis of the Gaia-ESO spectra was the work of multiple analys

Outcome under-ascertainment, characterized by the incomplete identification or reporting of cases, poses a substantial challenge in epidemiologic research. While capture-recapture methods can estimate unknown case numbers, their role in estimating exposure effects in observational studies is not well established. This paper presents an ascertainment probability weighting framework that integrates