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Hypermethylation of endoplasmic reticulum disulfide oxidase 1α leads to trophoblast cell apoptosis through endoplasmic reticulum stress in preeclampsia

Abnormal trophoblast cell apoptosis is implicated in the pathogenesis of pregnancy-related disorders including preeclampsia (PE), and endoplasmic reticulum (ER) stress has been considered as a novel pathway in the regulation of cell apoptosis. In this study, we observed that both apoptosis and ER stress are triggered in trophoblast cells under hypoxia as well as in the placenta of PE rats. Quantit

A novel partial volume correction method for accurate quantification of [18F] flortaucipir in the hippocampus

Background: Off-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [18F] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed using a novel partial volume correction method (PVC). Methods: PVC was performed on 20 [18F] flortaucipir dynamic PET scans (10 probable AD and 10 controls). Volumes of interest (VO

MCPLOTS : A particle physics resource based on volunteer computing

The mcplots.cern.ch web site (mcplots) provides a simple online repository of plots made with high-energy-physics event generators, comparing them to a wide variety of experimental data. The repository is based on the hepdata online database of experimental results and on the rivet Monte Carlo analysis tool. The repository is continually updated and relies on computing power donated by volunteers,

Evolution effects in Z0 fragmentation into charmonium

In Z0 decay into prompt charmonium, i.e. charmonium not originating from B-meson decays, the most important contribution is expected to come from colour-octet mechanisms. However, previous fixed-order calculations of the colour-octet contribution contain large logarithms which, in a more complete treatment, should be resummed to all orders. We study this resummation by using a Monte Carlo QCD casc

Quark Jet Fragmentation

A semiclassical model is presented for the way the energy of a fast quark is transformed into observable hadrons. It reproduces the features of 1 + 1 dimensional QED (the Schwinger model) concerning a flat rapidity distribution in the central region. In particular the model predicts that the probability to find a meson containing a leading quark is independent of the Feynman scaling variable. Also

Drop size distribution and LWC in Po valley fog

In this paper results are presented of ground-based fog microphysical measurements obtained during the CHEMDROP experiment in the Po Valley (Northern Italy) in November 1994. Altogether about 85 hours of drop microphysical data are analyzed. At the beginning of the experiment a comparison of some of the different microphysical instruments, operated during the experiment, was performed. It has reve

PIXE and proton microprobe advances at the Lund Institute of Technology

A review of recent advances in high-energy ion beam analysis at the Lund Institute of Technology is presented. A nonvacuum specimen chamber allows chemical speciation using a combination of ion beam analysis and controlled heating. The development of a new versatile scanning proton microbeam based on a new dedicated accelerator, an achromatic triplet lens and an advanced specimen chamber is outlin

Inner-shell ionization processes in low Z (Z ≤ 20) elements by proton bombardment

K-shell X-ray ionization cross section from thin targets of P, S, Cl, K and Ca by proton impact in the energy range of 1.0-5.0 MeV are reported using a Si(Li) detector. Our experimental results are compared with previous very scanty available data and with ECPSSR theory. Data for P are reported for the first time. Results for S, Cl and K in this wide energy range are also new data. Our results sho

Circadian onset and prognosis of myocardial infarction with non-obstructive coronary arteries (MINOCA)

Background Many acute cardiovascular events such as myocardial infarction (MI) follow circadian rhythms. Myocardial infarction with non-obstructive coronary arteries (MINOCA) is a newly noticed entity with limited data on onset pattern and its impact on prognosis. Material and methods In this observational study of Swedish MINOCA patients registered in the SWEDEHEART registry between 2003–2013 and