BACKGROUND: Widespread pain is a common comorbidity in several chronic diseases and is suspected to be caused by the underlying disease that has provoked a state of central sensitization. However, this argument is currently limited by evidence that has not sufficiently captured the temporal nature of the relationship between diagnosis of the underlying disease and onset of widespread pain. The aim

Microbial attachment to mucosal surfaces is a first step in mucosal infection. Specific interactions between microbial surface ligands and host receptors influence the distribution of microbes in their sites of infection. Adhesion has often been regarded as a sufficient end point, explaining tissue tropism and bacterial persistence at mucosal sites. Adherence, however, is also a virulence factor t

In this talk we discuss the recent progess in the computation and simulation of multi-leg hadronic final states. We focus on three recent developments: (i) Minlo as a path NNLOPS, (ii) NLO EW corrections and their matching to parton showers, and (iii) incorporating NLO splitting functions in parton showers.

It is argued that rules and norms are conceptually distinct. What is norm is not a rule, and vice versa. Versions of conflating the two are discussed and an argument for distinction given. Objections to the argument are responded to. It is accepted that rules and norms are intimately related, but they are so causally, not conceptually. What norms we live by makes a difference to what rules we acceThis paper argues that rules and norms are conceptually distinct: what is norm is not thereby rule, and vice versa. Versions of conflating the two are discussed and an argument for distinction given. Two objections to the argument are responded to. It is accepted that rules and norms are often intimately related. They are so causally, not conceptually: what norms we live by can make a difference t

BACKGROUND: An individual's subjective perception of well-being is increasingly recognized as an essential complement to clinical symptomatology and functional impairment in children's mental health. Measurement of quality of life (QoL) has the potential to give due weight to the child's perspective.SCOPE AND METHODOLOGY: Our aim was to critically review the current evidence on how childhood menta

The Transiting Exoplanet Survey Satellite (TESS) will provide high-precision time series photometry for millions of stars with at least a half-hour cadence. Of particular interest are the circular regions of 12° radius centred around the ecliptic poles that will be observed continuously for a full year. Spectroscopic stellar parameters are desirable to characterize and select suitable targets for

We determine approximate numerical integrals of motion of 2D symmetric Hamiltonian systems. We detail for a few gravitational potentials the conditions under which quasi-integrals are obtained as polynomial series. We show that each of these potentials has a wide range of regular orbits that are accurately modelled with a unique approximate integral of motion.

3D multi-gradient echo MRI can be used to estimate T1, T2*, PD and the magnetization transfer (MT), which is increasingly used for multi-parametricmapping (MPM) of human brain. The increased polarization at 7T compared to lower B0 allows for increased spatial resolution or reduced scantimes. However, SAR restrictions imposed on the MT pulse and B1 inhomogeneity pose challenges. In this work, we pr

Background: Urothelial bladder cancer (UBC) is a disease that often is discovered when the tumour is non-muscle invasive, i.e. in Ta or T1 stage. Some patients will progress into muscle-invasive disease, a potentially deadly condition. Although there are some prognostic models, the need for prognostic and predictive biomarkers is considerate and urgent. Membranous expression of podocalyxin-like pr

Determining the most desirable and achievable target dose and organ at risk (OAR) sparing using helical TomoTherapy planning system for mesothelioma treatment plans. A range of planning parameters was used. The reviewers’ ranking assessment (Ranking in Groups: 1 = Good, 2 = Above Average, 3 = Average, 4 = Poor).The overall rankings revealed that a plan with a balanced tradeoff among all planning o

Studies on the impact of cleft palate surgery on speech with stringent methodology are called for, since we still do not know the best timing or the best method for surgery. The purpose was to report on speech outcome for all Swedish-speaking 5-year-olds born with a non-syndromic unilateral cleft lip and palate (UCLP), in 2008–2010, treated at Sweden’s six cleft palate centres, and to compare spee

Introduction: Dupuytren's disease (DD) causes progressive digital flexion contracture and is more common in men of European descent. Methods: Orthopaedic and plastic surgeons in 12 European countries (the Czech Republic, Denmark, Finland, France, Germany, Hungary, Italy, The Netherlands, Poland, Spain, Sweden and the UK) with >3 and

The limit of validity of linear fracture mechanics is specified by the minimum allowable crack length through an ASTM convention. Extension into the non-linear region ought to imply an extension towards smaller allowable Cracks. In order to elucidate the question "How short is the smallest crack that fits the methods of fracture mechanics, and how do shorter cracks than that behave?" a pilot inves

The official iMechanica Blog for the Elsevier Journal Engineering Fracture Mechanics

The official iMechanica Blog for the Elsevier Journal Engineering Fracture Mechanics