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Deep thiopental anesthesia alters steady-state glucose homeostasis but not the neurochemical profile of rat cortex

Barbiturates are regularly used as an anesthetic for animal experimentation and clinical procedures and are frequently provided with solubilizing compounds, such as ethanol and propylene glycol, which have been reported to affect brain function and, in the case of (1)H NMR experiments, originate undesired resonances in spectra affecting the quantification. As an alternative, thiopental can be admi

Activated protein C resistance : from phenotype to genotype and clinical practice

The anticoagulant protein C system is an important regulator of the blood coagulation process. Its targets are the procoagulant cofactors factor Va and factor VIIIa, which are cleaved and inactivated by activated protein C, protein S and intact factor V working as cofactors. Genetic defects of protein C or protein S were, together with antithrombin III deficiency, the previously established major

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Despite having the best statistics in developing countries, there are a number of gaps in Chile's economic series, which have been being corrected over the years. Our joint work has allowed knowing the similarities and differences between series made from the Chilean statistical yearbooks and official trade statistics of G-3 (Germany, USA and Great Britain). The article aims to contrast both machi

Resistance to activated protein C, the FV:Q506 allele, and venous thrombosis

Vitamin K-dependent protein C is an important regulator of blood coagulation. After its activation on the endothelial cell surface by thrombin bound to thrombomodulin, it cleaves and inactivates procoagulant cofactors Va and VIIIa, protein S and intact factor V working as cofactors. Until recently, genetic defects of protein C or protein S were, together with antithrombin III deficiency, the estab

A common thrombomodulin amino acid dimorphism is associated with myocardial infarction

Endothelial dysfunction and haemostatic imbalance are believed to be important aetiological factors in the development of acute coronary syndromes. Thrombomodulin (TM) is an integral membrane protein crucial for normal endothelial function and activation of the protein C anticoagulant pathway. We have investigated the importance of a common C/T dimorphism in the TM gene (nucleotide 1418) for devel

Bridging across length scales : multi-scale ordering of supported lipid bilayers via lipoprotein self-assembly and surface patterning

We show that a two-step process, involving spontaneous self-assembly of lipids and apolipoproteins and surface patterning, produces single, supported lipid bilayers over two discrete and independently adjustable length scales. Specifically, an aqueous phase incubation of DMPC vesicles with purified apolipoprotein A-I results in the reconstitution of high density lipoprotein (rHDL), wherein nanosca

Evaluation of novel hollow fiber membranes for NOM removal by advanced membrane autopsy

A full-scale inside out hollow fibre membrane module was operated in a pilot-scale water treatmentplant in Sweden for a period of 12 months from August 2013 to July 2014. Liquid chromatography–organic carbon detection (LC-OCD) chromatogram indicated the membranes could effectivelyremove 86% of dissolved organic carbon and 92% of humic substances from the feedwater. Routinecleaning-in-place was conA full-scale inside out hollow fibre membrane module was operated in a pilot-scale water treatment plant in Sweden for a period of 12 months from August 2013 to July 2014. Liquid chromatography– organic carbon detection (LC-OCD) chromatogram indicated the membranes could effectively remove 86% of dissolved organic carbon and 92% of humic substances from the feedwater. Routine cleaning-in-place was

Gender Equality in Employment in Turkish Legislation with Comparisons to EU and International Law

As a candidate for membership of the European Union (EU), Turkey has to harmonize its existing legislation with the EU requirements for gender equality in employment. Also the amended Turkish Constitution states that where a conflict between ratified international treaties and domestic law exists, international treaties shall prevail. These treaties are binding upon the legislative, executive, and

Serum Potassium Is Positively Associated With Stroke and Mortality in the Large, Population-Based Malmö Preventive Project Cohort

BACKGROUND AND PURPOSE: Low serum potassium is associated with stroke in populations with cardiovascular disease, hypertension, and diabetes mellitus but has not been studied in a mainly healthy population. We aimed to study the relation between serum potassium and incident stroke and mortality in the Malmö Preventive Project, a large cohort with screening in early mid-life and follow-up >25 years

Jedek : a newly discovered Aslian variety of Malaysia

Jedek is a previously unrecognized variety of the Northern Aslian subgroup of the Aslian branch of the Austroasiatic language family. It is spoken by about 280 individuals in the resettlement area of Sungai Rual, near Jeli in Kelantan state, Peninsular Malaysia. The community originally consisted of several bands of foragers along the middle reaches of the Pergau river. Jedek’s distinct status fir