Background and purpose: Dementia is one of the most common disorders and is associated with increased morbidity, mortality and decreased quality of life. The present guideline addresses important medical management issues including systematic medical follow-up, vascular risk factors in dementia, pain in dementia, use of antipsychotics in dementia and epilepsy in dementia. Methods: A systematic rev

Visualizing ligand binding interactions is important for structure-based drug design and fragment-based screening methods. Rapid and uniform soaking with potentially reduced lattice defects make small macromolecular crystals attractive targets for studying drug binding using microcrystal electron diffraction (MicroED). However, so far no drug binding interactions could unambiguously be resolved by

This chapter focuses on legal interpretation, reflecting on policy options between pluralism and harmonisation in two separate levels: (1) the desirability of establishing, or not, further harmonisation of interpretative rules, criteria and praxis in IP law; (2) whether internal harmonisation or systemic coherence between different areas of law and regulation that affect the same object or legal f

Open Source Security and Dependency Vulnerability Management (DVM) has become a more vital part of the software security stack in recent years as modern software tend to be more dependent on open source libraries. The largest open source of vulnerabilities is the National Vulnerability Database (NVD), which supplies developers with machine-readable vulnerabilities. However, sometimes Common Vulner

Petrochemical enterprises in Kazakhstan discharge polluted wastewater into special recipients. Contaminants infiltrate through the soil into the groundwater, which potentially affects public health and environment safety. This paper presents the evaluation of a 7-year monitoring program from one of the factories and includes nineteen variables from nine wells during 2013–2019. Several multivariate

Increased incidence of narcolepsy type 1 (NT1) was observed following Pandemrix®‐vaccination, initiated as a preventive measure against the 2009 Influenza pandemic. Here, single cell analysis was conducted to suggest a lower number of CD8+CD27+ T cells among these patients. These findings provide understanding into the autoimmune pathogenesis of NT1.

Post-fracture care (PFC) programs evaluate and manage patients with a minimal trauma or fragility fracture to prevent subsequent fractures. We conducted a literature review to understand current trends in PFC publications, evaluate key characteristics of PFC programs, and assess their clinical effectiveness, geographic variations, and cost-effectiveness. We performed a search for peer-reviewed art

Patient participation and the environment are critical factors in achieving qualitative healthcare. We conducted a systematic scoping review using Arksey and O’Malley’s framework to identify instruments intended to measure patient participation. We assessed those instruments’ characteristics, which areas of the healthcare continuum they target, and whether environmental factors are considered. Ins

Hans Henrik Lidgard enligt delegation Abstract: Konkurrensverkets undersökningar på plats innebär en stor belastning på företagen som normalt torde ha all anledning att försöka korta ner konkurrensverkets vistelse på företaget av i stort sett samma skäl som konkurrensverket av effektivitetsskäl önskar genomföra undersökningen i verkets egna lokaler när så är möjligt. Det förefaller därför sannolik

Dopamine replacement therapy with L-DOPA is the most efficacious symptomatic treatment for Parkinson's disease, but its utility is limited by a development of motor fluctuations and abnormal involuntary movements (dyskinesia) in the majority of patients. These complications are attributed to the combined effects of dopaminergic degeneration and non-physiological reinstatement of dopamine transmiss

Background: Swedish Emergency Departments (EDs) see 2.6 million visits annually. Sweden has a strong tradition of health care databases, but information on patients’ pathways to the ED is not documented in any registry. The aim of this study was to provide a national overview of pathways, degree of medical acuteness according to triage, chief complaints, and hospital admission rates for adult pati

How are bribes supposed to be given or taken? In this article, we study how individuals from countries with low tolerance of corruption learn, teach others and present themselves as knowledgeable about the etiquette of bribes. This involves the social practices of everyday corruption and petty bribes when working as ’strangers’ in countries where such exchanges are more common. Previous interviews

The transition from fossil jet fuel to biojet fuel is an important step towards reducing greenhouse gas (GHG) emissions from aviation. To enable such a fuel shift, the Swedish Government introduced a GHG emission reduction mandate of 27% by 2030 for aviation fuel sold in Sweden, forcing fuel suppliers to blend in biojet fuel in fossil jet fuel. A similar policy instrument is being discussed within

Edinburgh was an Enlightenment city of regional, national and global influence. But how did the people of Enlightenment Edinburgh understand and order their world? How did they encounter, compare and produce different kinds of spaces, from the urban to the world scale? And how did this city set the universal standards by which other places should be judged and transformed?The Geographies of Enligh

BACKGROUND: The recent systematic adoption of intracameral antibiotic injection during cataract surgery in Sweden, India, and the US serves as a model for the successful transitioning of local quality improvement initiatives to organization-wide implementation. Although the delivery of eye care in the 3 countries is distinctly organized with differing governances and technological infrastructure,