Background: Mobile health (mHealth), wearable activity trackers (WATs) and other digital solutions could support physical activity (PA) in individuals with hip and knee osteoarthritis (OA), but little is described regarding experiences and perceptions of digital support and the use of WAT to self-monitor PA. Thus, the aim of this study was to explore the experiences of using a WAT to monitor PA an

Aquaporin-9 (AQP9) is a facilitator of glycerol and other small neutral solute transmembrane diffusion. Identification of specific inhibitors for aquaporin family proteins has been difficult, due to high sequence similarity between the 13 human isoforms, and due to the limited channel surface areas that permit inhibitor binding. The few AQP9 inhibitor molecules described to date were not suitable

Colour vision allows animals to use the information contained in the spectrum of light to control important behavioural decisions such as selection of habitats, food or mates. Among arthropods, the largest animal phylum, we find completely colour-blind species as well as species with up to 40 different opsin genes or more than 10 spectral types of photoreceptors, we find a large diversity of optic

Background: Few studies have evaluated the efficacy of ketamine-assisted psychotherapy (KAP) in the treatment of treatment-resistant depression (TRD) and substance use disorders (SUD). Methods: A systematic review of clinical trials reporting on the efficacy of KAP and discussing mechanisms of action, identified on PubMed and PsycInfo. Results: Five randomized-controlled trials reported on the eff

Estimation of the defect content is important to enable quality control throughout the software development process. Capture-recapture methods and curve fitting methods have been suggested as tools to estimate the defect content after a review: The methods are highly reliant on the quality of the data. If the number of reviewers is fairly small, it becomes difficult or even impossible to get relia

This study focused on improving the performance of the near real-time Integrated Multi-satellitE Retrievals for Global Precipitation Measurement (IMERG) Early Run (IMERG-E) product based on a newly developed bias-correction scheme, LSCDF. The LSCDF was established by integrating the mean-based Linear Scaling (LS) and quantile-mapping Cumulative Distribution Function (CDF) matching approaches. The

Ball rolling dung beetles use a wide range of cues to steer themselves along a fixed bearing, including the spectral gradient of scattered skylight that spans the sky. Here, we define the spectral sensitivity of the diurnal dung beetle Kheper lamarcki and use the information to explore the orientation performance under a range of spectral light combinations. We find that, when presented with spect

Background:The optimal treatment of displaced femoral neck fractures in patients 55 to 70 years old remains controversial. The aim of the present study was to assess the effect of closed reduction and internal fixation with cannulated screws (IF) compared with total hip arthroplasty (THA) on hip pain and function, with use of data for outcome measures, complications, and reoperations.Methods:This

Background: Dizziness and vertigo affect around 15% of adults annually and represent common reasons for contacting health services, accounting for around 3% of all emergency department visits worldwide. Vertigo is also associated with excessive use of diagnostic imaging and emergency care and decreased productivity, primarily because of work absenteeism. Vestibular rehabilitation is an evidence-ba

The ISSCR has developed the Informed Consent Standards for Human Fetal Tissue Donation and Research to promote uniformity and transparency in tissue donation and collection. This standard is designed to assist those working with and overseeing the regulation of such tissue and reassure the wider community and public.

Lateglacial and Holocene summer sea-surface temperature (SST) variability in the northern North Atlantic was reconstructed based on diatom records from two sediment cores from the North Icelandic shelf. The temperature changes are discussed in relation to palaeoceanographic circulation patterns and past climatic changes. Modern diatom data from surface sediments from around Iceland and Southeast a

In a large, multiethnic cohort of youths with obesity, we analyzed pathophysiological and genetic mechanisms underlying variations in plasma glucose responses to a 180 min oral glucose tolerance test (OGTT). RESEARCH DESIGN AND METHODS Latent class trajectory analysis was used to identify various glucose response profiles to a nine-point OGTT in 2,378 participants in the Yale Pathogenesis of Youth

Following years of increasing bureaucracy and micro-management, there is a need for more trust in the judgement of street-level professionals and citizens in the public administration. After an intense debate in Sweden for several years, the Swedish Government launched a trust reform in 2016. This was organized around a government commission, called the Trust Commission. At the centre of its work

Background: Infertile men with non-obstructive azoospermia (NOA) have impaired spermatogenesis. Dilated and un-dilated atrophic seminiferous tubules are often present in the testes of these patients, with the highest likelihood of active spermatogenesis in the dilated tubules. Little is known about the un-dilated tubules, which in NOA patients constitute the majority. To advance therapeutic strate

With the increase of computing power, large eddy simulation (LES) within the Lagrangian–Eulerian two-phase flow framework has evolved as an useful numerical tool to gain insights to the spray combustion processes in advanced internal combustion engines. However, the inherent effect of grid/filter size (G/FS) on the physics revealed by LES is not fully understood. In this paper, we present several

Exocytosis in excitable cells is essential for their physiological functions. Although the exocytotic machinery controlling cellular secretion has been well investigated, the function of the vesicular cargo, i.e. secretory granular content remains obscure. Here we combine dSTORM imaging and single-domain insulin antibody, to dissect the in situ structure of insulin granule cores (IGCs) at nano lev

Transparency is generally cited as a key consideration towards building Trustworthy AI. However, the concept of transparency is fragmented in AI research, often limited to transparency of the algorithm alone. While considerable attempts have been made to expand the scope beyond the algorithm, there has yet to be a holistic approach that includes not only the AI system, but also the user, and socie