Gastric bypass surgery improves type 2 diabetes, but the weight loss independent mechanisms remain elusive. We set out to unravel a potential benefi cial role of gastric bypass surgery on islets of Langerhans. Eight week old male C57Bl/6 mice were fed a high fat diet (60% kcal fat) for 14 weeks and subsequently subjected to Roux-en-Y gastric bypass (RYGB; n=16). Weight matched (WMS; n=13) and pair

Inflation-targeting central banks commonly fail to hit their official inflation targets, so targets are combined with a tolerance band which is either implicit or explicit. Taking the Swedish Riksbank as an example, this column argues that adopting an explicit tolerance band would better communicate to the public the central bank’s lack of full control over the rate of inflation and thus foster puInflation-targeting central banks commonly fail to hit their official inflation targets, so targets are combined with a tolerance band which is either implicit or explicit. Taking the Swedish Riksbank as an example, this column argues that adopting an explicit tolerance band would better communicate to the public the central bank’s lack of full control over the rate of inflation and thus foster pu

Skildring av de profranska stämningarna inom Lunds universitet vid tiden för fransk-tyska kriget samt hur dessa sedan successivt förbyttes mot en ökad orientering mot Tyskland.

Microstructure and crystallographic texture are the key factors that determine the sputtering target properties. Clock rolling plays an important role in improving the microstructure homogeneity, but the effect of strain during rolling on deformation and recrystallization behavior is not clear. Thus, high-purity tantalum (Ta) plates were 135° clock rolled to 70% and 87% reduction and then annealed

The EU Blue Growth agenda is being implemented at a time when European coastal fisheries and traditional fishing communities are struggling to survive or have already vanished from areas where they used to flourish. Driven by the strong conviction that current disadvantaged and vulnerable coastal fishers still have a central role to play in rural development, local level initiatives are calling fo

In this study we investigate different parameters used for mapping global flame structures and identify the most universal in terms of comparing flames emerging from different geometrical burner arrangements. Simultaneously the study was carried out to determine the discharge conditions yielding the blue flame of a high degree of partial premixing, and to examine the instantaneous local flame stru

AQP7 is an important glycerol channel in human adipocytes, and its dysfunction is linked to metabolic disorders. The high-resolution X-ray structures of AQP7 unravels the molecular details of how glycerol travels through the channel and provide a structural basis for development of small-molecule drugs for targeting AQP7.

Cardiovascular disease (CVD) is the leading cause of death globally. In the European Union (EU) alone, CVD accounts for 1.8 million deaths each year. CVD is a group of disorders involving the heart and the blood vessels. The main risk factors of CVD include unhealthy lifestyles, tobacco smoking, and obesity. It has been demonstrated that chronic high blood pressure (medically termed hypertension)

Diagnostic measurement of electric skin conductivity (ESC) called the Ryodoraku system was introduced in mid 1950s by Nakatani. As has been shown by Ziobro et al. in case of infantile cerebral palsy, changes of ESC may provide a valuable electrophysiological parameter for monitoring a therapy. In this study ESC was measured in asthmatic children treated with a bioelectronic unit VEGA-SELECT. Analy

In the setting of transplantation, T cells are deliberately depleted to prevent allograft rejection. However, this IL-7 activates the accelerated proliferation of effector memory T cells, which are the predominant mediators of graft rejection. Multipotent adult progenitor cells (MAPC) have been previously shown to modulate the response of T cells to IL-7, in vitro but not in vivo. Here, for the fi

In the formulation of an active enzyme enclosed in a matrix for controlled delivery, it is a challenge to achieve a high protein load and to ensure high activity of the protein. For the first time to our knowledge, we report the use of a highly swollen lipid sponge (L3) phase for encapsulation of the large active enzyme, β-galactosidase (β-gal, 238 kDa). This enzyme has large relevance for applica

Background:Commonly used islet transplantation protocols experiencesignificant islet injury and graft loss; therefore new methods to support thelong-term benefits of this treatment are needed. Recent studies have shownthat non-endothelial bone marrow-derived multipotent adult progenitor cells(MAPC) possess significant immune-modulating abilities and can secreteangiogenic molecules, which could mak

OBJECTIVE: Type 2 diabetes mellitus (T2DM) is associated with dyslipidemia, but the detailed alterations in lipid species preceding the disease are largely unknown. We aimed to identify plasma lipids associated with development of T2DM and investigate their associations with lifestyle. RESEARCH DESIGN AND METHODS: At baseline, 178 lipids were measured by mass spectrometry in 3,668 participants wit

The antimicrobial peptide LL-37 is active against oral bacteria and has been demonstrated to be present in human saliva, but its distribution in different fractions of saliva is not known. LL-37 is formed from its intracellular pro-form, hCAP18, in an extracellular enzymatic reaction catalyzed by proteinase 3 and kallikrein 5. Here, we prepared cell-containing and cell-free fractions of unstimulat

OBJECTIVE: Recent in vivo results have shown prominent tissue sparing effect of radiotherapy with ultra-high dose rates (FLASH) compared to conventional dose rates (CONV). Oxygen depletion has been proposed as the underlying mechanism, but in vitro data to support this have been lacking. The aim of the current study was to compare FLASH to CONV irradiation under different oxygen concentrations in