Aging exerts profound effects on the hematopoietic system, leading to a loss of homeostatic control and reduced regenerative capacity. Clinical consequences of these changes include anemia, compromised immune function and an increased prevalence of myeloid disorders among the elderlies. A growing body of evidence suggests that defects at the stem and progenitor cell levels contribute to many of th

Familjen styltflugor (Dolichopodidae) är en flugfamilj som i Sverige rönt ganska stor uppmärksamhet under de senaste tvåhundra åren. Ett flertal checklistor har publicerats, den senaste 2004. Trots detta har ingen regelrätt landskapskatalog upprättats. En landskapskatalog visar inte bara vilka arter som finns i landet utan också i vilken del av landet de olika arterna förekommer. En tidsfönsterbas

Consider a dynamical systems ([0, 1], T, µ) which is exponentially mixing for L1 against bounded variation. Given a non-summable sequence (mk) of non-negative numbers, one may define rk(x) such that µ(B(x, rk(x)) = mk. It is proved that for almost all x, the number of k ≤ n such that Tk(x) ∊ Bk(x) is approximately equal to m1+· · ·+mn. This is a sort of strong Borel–Cantelli lemma for recurrence.

Delägande av bostadsrätter mellan en boendedelägare och en kommersiell delägare är en ny företeelse i Sverige. OBOS införde deleie-modellen efter att ha utvecklat den i Norge. Där har systemet fungerat väl under lång tid. Norska kommersiella aktörer är starkt begränsade av viktiga rättsregler och de rättsliga oklarheter som där finns håller på att klarläggas. Sverige är på många sätt annorlunda. O

The paper considers a time-adaptive finite element method for determination of drug efficacy in a parameter identification problem (PIP) for a system of ordinary differential equations (ODE) that describes dynamics of the primary human immunodeficiency virus (HIV) infection with drug therapy. Tikhonov’s regularization method, optimization approach and finite element method to solve this problem ar

Background It is clinically important to predict the conversion of major depression (MD) to bipolar disorder (BD). Therefore, we sought to identify related conversion rates and risk factors. Methods This cohort study included the Swedish population born from 1941 onward. Data were collected from Swedish population-based registers. Potential risk factors, including family genetic risk scores (FGRS)

About a third of all meteorites that fall on Earth today, the stony L-chondrites, originate from a major breakup event in the asteroid belt 466 Ma, in the early Darriwilian. This is the largest asteroid breakup in the past three billion years documented by K-Ar gas-retention ages of recently fallen meteorites. There has been a debate whether the breakup had any effects on Earth’s biota. Based main

Background and Purpose: High levels of Ca2+ in the endoplasmic reticulum (ER), established by the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), are required for protein folding and cell signalling. Excessive ER Ca2+ release or decreased SERCA activity induces unfolded protein accumulation and ER stress in pancreatic β-cells, leading to defective insulin secretion and diabetes. Here we have inve