Sökresultat

Background Coronavirus disease 2019 (COVID-19) is a rapidly spreading disease that has caused extensive burden to individuals, families, countries, and the world. Effective treatments of COVID-19 are urgently needed. Methods and findings This is the first edition of a living systematic review of randomized clinical trials comparing the effects of all treatment interventions for participants in all

Background: Management of schizophrenia is sub-optimal in many patients. Targeting negative symptoms, among the most debilitating aspects of schizophrenia, together with positive symptoms, can result in significant functional benefits and dramatically improve quality of life for patients and their carers. Cariprazine, a partial agonist of the dopamine receptors D2/D3 has demonstrated effectiveness

Modern health care requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyping, and the development and application of reliable biomarkers. A detailed clinical history and phy

The COVID-19 pandemic may have severe impact on mental health, and concerns have been raised about potentially increased online behavior and possibly increased gambling problems, such as in sports bettors at risk of transfer to even riskier forms of gambling during sports lock-down. Given the need for objective data about gambling behavior during the pandemic, the present analysis, from a project

Projektet Stafetten har studerat miljömål på nationell, regional och lokal nivå,deras roll för transportplaneringen, och vad som kan göras för att målen skafå större genomslag. De senaste två omgångarna av nationell transportplanstuderades med hjälp av litteraturstudier och intervjuer. Fallstudier gjordesav regional transportplanering och kommunal samhällsplanering på motsvarande sätt. Detta mater

Objective: There are growing concerns about the short- and long-term consequences of sports-related concussion, which account for about 5–9% of all sports injuries. We hypothesized there may be sex differences in concussion history and concussion-related symptoms, evaluated among elite soccer players in Sweden. Design: Retrospective survey study. Participants and Setting: Soccer players (n = 1,030

Background and aims: Children with extremely low-birth weight (ELBW) have a high risk for cognitive, motor, and attention impairments and learning disabilities. Longitudinal follow-up studies to a later age are needed in order to increase understanding of the changes in neurodevelopmental trajectories in targeting timely intervention. The aims of this study were to investigate cognitive and motor

EUTelescope is a modular, comprehensive software framework for the reconstruction of particle trajectories recorded with beam telescopes. Its modularity allows for a flexible usage of processors each fulfilling separate tasks of the reconstruction chain such as clustering, alignment and track fitting. The framework facilitates the usage of any position sensitive device for both the beam telescope

Introduction Breathlessness is common in the general population and associated with poorer health. Prevalence, frequencies and overlap of underlying contributing conditions among individuals reporting breathlessness in the general population is unclear. The aim was to evaluate which conditions that were prevalent, overlapping and associated with breathlessness in a middle-aged general population.

The concept of the right temporal variant of frontotemporal dementia (rtvFTD) is still equivocal. The syndrome accompanying predominant right anterior temporal atrophy has previously been described as memory loss, prosopagnosia, getting lost and behavioural changes. Accurate detection is challenging, as the clinical syndrome might be confused with either behavioural variant FTD (bvFTD) or Alzheime

Background: The COVID-19 outbreak has resulted in collision between patients infected with SARS-CoV-2 and those with cancer on different fronts. Patients with cancer have been impacted by deferral, modification, and even cessation of therapy. Adaptive measures to minimize hospital exposure, following the precautionary principle, have been proposed for cancer care during COVID-19 era. We present he

Introduction: Post-traumatic stress disorder (PTSD) and substance use disorder frequently co-occur and tend to have their onset during adolescence. Although research has highlighted the importance of treating these disorders in an integrated fashion, there is a dearth of empirically validated integrated treatment options for adolescents with this comorbidity. This paper describes the study protoco

Internet-of-things systems are difficult to understand and debug due to their distributed nature and weak connectivity. We address this problem by using relational reference attribute grammars to model and analyze IoT systems with unreachable parts. A transitive device-dependency analysis is given as an example.

Managing variability in control programs often requires code duplication or that all variants are anticipated in advance. In this paper, we present a new approach to obtaining modular functionality reuse across variants. Using the language mechanisms diagram inheritance and connection interception, a feature model and an interactive feature-selection wizard can be automatically derived from the co

The amyloid cascade hypothesis, according to which the self-assembly of amyloid-β peptide (Aβ) is a causative process in Alzheimer’s disease, has driven many therapeutic efforts for the past 20 years. Failures of clinical trials investigating Aβ-targeted therapies have been interpreted as evidence against this hypothesis, irrespective of the characteristics and mechanisms of action of the therapeu

The name Edward Marsh occasionally crops up in handbooks on English literature, where he is mentioned as the editor of the five volumes of Georgian Poetry that appeared from 1912 to 1922. Georgian poetry, however defined, has been decried for the best part of a century, and Marsh’s reputation among representatives of English Literature has been correspondingly lacklustre. This article presents a r

This study provides new quantitative NO concentrations measurements in n-propanol + air and i-propanol + air flames together with a new combustion kinetic model. The heat flux method was employed to stabilize propyl alcohols flames and the initial gas conditions were set to 323 K, 1 atm, and ϕ=0.7-1.4. Saturated laser-induced fluorescence was employed to measure NO concentration in the post-combus