Filtyp
Regenerative medicine is an emerging and rapidly evolving field of research and therapeutics aimed to restore, maintain, and improve body functions. In the adult mammalian brain, very few neurons, if any, are generated after disease onset or an injury, and its ability to self-repair is therefore limited. Replacing neurons that are lost during neurodegenerative diseases or due to injury therefore r
The transformation of a polyacrylonitrile (PAN) precursor fibre into carbon fibre using varying stabilization times during carbon fibre manufacture is presented in this work. The wet-spun precursor fibre is a specifically designed PAN co-polymer made up of acrylonitrile, methyl acrylate and 3 wt% itaconic acid. The residence or stabilization times in the oxidation ovens are varied from 32, 64 and
Resilience – broadly understood as withstanding, and adapting to, shocks and risks – has emerged as a central discursive device for converging humanitarian needs with climate change responses. This paper's human-centred engagement with resilience draws on the case of smallholder farmers engaged in rain-fed cocoa production in Ghana's Central Region, to systematically unpack how poverty shapes smal
One way of controlling global warming is to substitute fuel driven cars with electric cars. Electric vehicles need to be charged. For maximal efficiency the charging times should be as short as possible. In the US charging stations are classified as Level 1 charging 5–10 miles/h, Level 2 25 miles/h and Fast DCFC stations 150–1000 miles/h. We asked participants to select one of two upgrades of char
The cerebral blood flow, CBF, is an important clinical parameter in neuro-intensive care. The possibility to continuously monitor CBF, computed from referential ICP, rICP (calculated from measured intracranial pressure, ICP, and central venous pressure, CVP) and venous outflow resistance, Rv, could importantly improve patient care. For the CBF(1) method the pulsative part of CBF (with rICP increas
COVID-19 is a severe respiratory disease affecting millions worldwide, causing significant morbidity and mortality. Adrenomedullin (bio-ADM) is a vasoactive hormone regulating the endothelial barrier and has been associated with COVID-19 mortality and other adverse events. This prospective cohort pilot study included 119 consecutive patients with verified SARS-CoV-2 infection admitted to two inten
Due to the fragility of the ophiuroid (brittle star) skeleton, the bulk of the group’s fossil record consists of dissociated ossicles preserved as microfossils. In spite of their great potential as basis for taxonomic and phylogenetic studies, however, ophiuroid ossicles from the Paleozoic have received very little attention so far. Here, we provide an exhaustive taxonomic assessment of such fossi
Granular materials (assemblies of contacting grains with inter-granular porosity) form a vast family of materials important in both natural and industrial contexts. Under mechanical loads such systems show complex behaviours relating to the inter-and intra-granular stresses, strains and force transmission as well as the individual grain kinematics and interactions leading to multi-scale, heterogen
The effective macroscopic behaviour of a material is a manifestation of the underlying microstructure and microscale processes. This renders the generation of highly accurate digital microstructure twins indispensable for multiscale simulations. MOSAIC is a Python-based, open-source software tool designed to address the challenge of incorporating non-planar, periodic microstructures generated by t
Microorganisms play a crucial role in various physiological processes, including metabolism, immune defense, nutrition absorption, defense against cancer, and protection against pathogen colonization. Changes in microbial communities serve as potential biomarkers for diseases, offering significant insights into disease treatment and diagnosis. However, the association between microorganisms and di
Structure-based drug design is highly dependent on the availability of structures of the protein of interest in complex with lead compounds. Ideally, this information can be used to guide the chemical optimization of a compound into a pharmaceutical drug candidate. A limitation of the main structural method used today - conventional X-ray crystallography - is that it only provides structural infor
Although fathers experience emotional stress both during the care period and after discharge, there is limited research focusing exclusively on fathers’ experiences after their time in a neonatal intensive care unit. Their experiences are important for tailoring support to fathers based on their individual needs. This paper is part of a longitudinal study in which parents were followed by means of
Introduction Management of testicular torsion varies between specialties resulting in lack of standardization. The aim of this survey was to assess pre-, peri-, and postoperative differences. Methods An online questionnaire was distributed in 2023 to general and pediatric surgeons, pediatric urologists, and urologists by the Trainees of European Pediatric Surgery. Main Results Among 88 respondents
In this, the tenth annual update for the F1000Research Tics collection, we summarize research reports from 2023 on Gilles de la Tourette syndrome and other tic disorders. The authors welcome article suggestions and thoughtful feedback from readers.
Background: The detrimental impacts of adverse childhood experiences (ACEs) on health have been extensively studied, mainly focusing on the effects of ACEs on adults. However, there is a dearth of studies exploring their influences on adolescents. Objective: This study aims to investigate the associations between ACEs and psychological distress among Swedish adolescents. Participants and setting:
The European spruce bark beetle is a major disturbance agent in Norway spruce forests in Europe, and with a changing climate it is predicted that damage will increase. To prevent the bark beetle population buildup, and to limit further spread during outbreaks, it is crucial to detect attacked trees early. In this study, we utilize Sentinel-2 data in combination with a risk map, created from geodat
Introduction: The scapular osseous free flap (SOFF) is being increasingly used for complex head and neck reconstructions. This study examined the surgical outcomes, focusing on post-operative complications and sequelae in patients who underwent SOFF for maxillary and mandibular reconstructions. Material and Methods: This retrospective, observational, population-based study included patients who un
In this study, wireless embedded relative humidity, RH, probes, developed by Electrotech Kalix AB, were evaluated in a laboratory setting. These RH-probes are designed to monitor the drying of concrete at construction sites in a Swedish climate. Two concrete slabs, each with a thickness of 100 mm, were fabricated, using two different concrete mixes, with water-to-cement (w/c) ratios of 0.6 and 0.4
This paper discusses the role of different factors determining the linguistic competence of heritage speakers (HSs) based on examples from speakers who speak a Romance language (French, Italian, Portuguese, or Spanish) as heritage language (HL) and German as the environmental language. Since the relative amount of contact with the HL and the environmental language may vary during the acquisition p
