The accumulation of senescent cells drives inflammaging and increases morbidity of chronic inflammatory lung diseases. Immune responses are built upon dynamic changes in cell metabolism that supply energy and substrates for cell proliferation, differentiation, and activation. Metabolic changes imposed by environmental stress and inflammation on immune cells and tissue microenvironment are thus chi

The upcoming Artificial Intelligence (AI) Act is the European Union's attempt to regulate high-risk AI systems and foundation models. We give an up-to-date overview of the act's key requirements, explain how the high-risk classification works, and highlight what matters for its operationalization.

Tysta leken är en konceptuellt utforskande sång som utgår från ett ifrågasättande av den ritualiserade konsertformen inom konstmusiken. Syftet med det konstnärliga arbetet var att gestalta de sociala konventioner som återfinns i själva konsertsituationen. Genom att författa, komponera och framföra verket kunde temat artikuleras och bli föremål för kritisk diskussion. Arbetet resulterade i ett note

Monitoring available feed for livestock is a key factor for developing pastoralism in the Sahel, and satellite images has proven useful in monitoring dry mass on large spatial scales. This approach requires field measurements of dry mass (herbaceous and woody plants) to calibrate such models based on Earth observation data. However, the need for representative field measurements can be a challenge

The development of operatic works that involve artificial intelligence (AI) is an expanding field of artistic inquiry. In order to test how AI-generated text can be used in a dynamic and responsive opera libretto, the prototypical micro-opera The Oracle was conceived and presented live at PlayLab in Skövde. The theme of the immersive opera was the myth of the Delphic oracle, with the twist that th

A recent singleshot multiplane image (MPI) generation enables to copy an observed reality within a camera frame into other reality domains via view synthesis. While the scene scale is unknown due to the nature of singleshot MPI processing, camera tracking algorithms can estimate depth within the application world coordinate system. Given such depth information, we propose to adjust the scale of si

Chronos minnesbank är en experimentell opera i vilken besökarna behandlas som spelare istället för publik. Genom verket introducerades uppdragsinstruktioner för rollspelande operabesökare och den modulbaserade formen gav utrymme för dynamiskt sammansatta och varierade upplevelser utifrån ett och samma grundmaterial. Syftet med det konstnärliga arbetet var att pröva operabesökares benägenhet till i

A role of Yes1-associated transcriptional regulator (YAP) and WW domain-containing transcription regulator 1 (TAZ) in vascular and gastrointestinal contractility due to control of myocardin (Myocd) expression, which in turn activates contractile genes, has been demonstrated. Whether this transcriptional hierarchy applies to the urinary bladder is unclear. We found that YAP/TAZ are expressed in hum

We present a geometric approach to portfolio theory with a focus on risk-adjusted returns, in particular Jensen’s alpha. We find that while the alpha/beta approach has severe limitations, especially in higher dimensions, only minor conceptual modifications (e.g., using orthogonal Sharpe ratios rather than risk-adjusted returns) are needed to identify the efficient trading strategies. We further sh