Sökresultat

Filtyp

Din sökning på "*" gav 530019 sökträffar

Deep, rapid, and durable prostate-specific antigen decline with apalutamide plus androgen deprivation therapy is associated with longer survival and improved clinical outcomes in TITAN patients with metastatic castration-sensitive prostate cancer

Background: The first interim analysis of the phase III, randomized, double-blind, placebo-controlled, multinational TITAN study demonstrated improved overall survival (OS) and radiographic progression-free survival (rPFS) with apalutamide added to ongoing androgen deprivation therapy (ADT) in patients with metastatic castration-sensitive prostate cancer. The final analysis confirmed improvement i

Time and space resolved operando synchrotron X-ray and Neutron diffraction study of NMC811/Si–Gr 5 Ah pouch cells

Silicon–Graphite blended electrodes in Li-ion batteries have been proposed as a way to harness the high capacity of Si as an anode material, while minimising the negative effects of their large volume expansion. NMC 811 is the current state-of-the-art layered oxide cathode material, where the cobalt content of the cathode has been minimised. These are the two of the most promising materials for ac

The risk of post-polio syndrome among immigrant groups in Sweden

To examine the risk of post-polio syndrome (PPS) in immigrant groups using native Swedish-born individuals as referents. This is a retrospective study. The study population included all individuals aged 18 years and older registered in Sweden. PPS was defined as having at least one registered diagnosis in the Swedish National Patient Register. The incidence of post-polio in different immigrant gro

Mitochondrial complex III deficiency drives c-MYC overexpression and illicit cell cycle entry leading to senescence and segmental progeria

Accumulating evidence suggests mitochondria as key modulators of normal and premature aging, yet whether primary oxidative phosphorylation (OXPHOS) deficiency can cause progeroid disease remains unclear. Here, we show that mice with severe isolated respiratory complex III (CIII) deficiency display nuclear DNA damage, cell cycle arrest, aberrant mitoses, and cellular senescence in the affected orga

ESTRO-EANO guideline on target delineation and radiotherapy details for glioblastoma

Background and Purpose: Target delineation in glioblastoma is still a matter of extensive research and debate. This guideline aims to update the existing joint European consensus on delineation of the clinical target volume (CTV) in adult glioblastoma patients. Material and Methods: The ESTRO Guidelines Committee identified 14 European experts in close interaction with the ESTRO clinical committee

Roles of TGF-β signals in tumor microenvironment via regulation of the formation and plasticity of vascular system

Tumor cells evolve in tumor microenvironment composed of multiple cell types. Among these, endothelial cells (ECs) are the major players in tumor angiogenesis, which is a driver of tumor progression and metastasis. Increasing evidence suggests that ECs also contribute to tumor progression and metastasis as they modify their phenotypes to differentiate into mesenchymal cells through a process known

What will it take for an Indian city to become low carbon? : A beginner’s guide to the sector-coupling approach, urban typologies, and the key to just transitions.

By 2050, seven billion people will be living in cities. In 2020 itself, these cities dumped a whopping 29 trillion tonnes of carbon dioxide into the atmosphere. This carbon dioxide along with other greenhouse gases poses a serious health hazard. It also manifests as extreme weather events, leading to the loss of lives, livelihoods, assets, and social wellbeing.Given the significant impact that cit

Mässfirande under en pandemi

Det är en debattartikel där författarna argumenterar för att stora fysiska samlingar är inte ett obetingat religiöst krav, även om det är något som många längtar efter. Man bör vara försiktiga med att åberopa religionsfrihetsargumentet när det gäller att utkräva olika typer av rättigheter, såsom mässfirande i större grupper under en pandemi.

The planar low temperature Coulomb gas: separation and equidistribution

We consider planar Coulomb systems consisting of a large number nn of repelling point charges in the low temperature regime, where the inverse temperature β grows at least logarithmically in n as n→∞, i.e., β≳log⁡n.Under suitable conditions on an external potential, we prove results to the effect that the gas is with high probability uniformly separated and equidistributed with respect to the corr

Towards regenerative regional development in responsible value chains : an agentic response to recent crises

In this paper, we empirically and theoretically present regenerative regional development in responsible value chains as an alternative to the prevailing traditional, neoliberal economic rationale of globalization. We develop the argument on the back of a longitudinal in-depth case study on actors’ engagement in the recurring crises in the maritime industry in Sunnmøre/Norway. The alternative pers

Carbon dioxide flooding to reduce postoperative neurological injury following surgery for acute type A aortic dissection : a prospective, randomised, blinded, controlled clinical trial, CARTA study protocol - objectives and design

INTRODUCTION: Neurological complications after surgery for acute type A aortic dissection (ATAAD) increase patient morbidity and mortality. Carbon dioxide flooding is commonly used in open-heart surgery to reduce the risk of air embolism and neurological impairment, but it has not been evaluated in the setting of ATAAD surgery. This report describes the objectives and design of the CARTA trial, in

Reduced binding of apoE4 to complement factor H promotes amyloid-β oligomerization and neuroinflammation

The APOE4 variant of apolipoprotein E (apoE) is the most prevalent genetic risk allele associated with late-onset Alzheimer's disease (AD). ApoE interacts with complement regulator factor H (FH), but the role of this interaction in AD pathogenesis is unknown. Here we elucidate the mechanism by which isoform-specific binding of apoE to FH alters Aβ1-42-mediated neurotoxicity and clearance. Flow cyt

Normal science and the hidden lemmas of mathematical epidemiology

Normal science is a characterization of science in our epoch and a demarcation of what “scientific” means. It divides science in disciplined/normed paradigms. Mathematical epidemiology is the paradigm that regulates the activity of mathematicians with respect to the study of epidemics. It also represents the interest (multiple meanings implied) of the community that guards it. In contrast, a real

Affinity-Purification Combined with Crosslinking Mass Spectrometry for Identification and Structural Modeling of Host-Pathogen Protein-Protein Complexes

Host-pathogen protein-protein interactions are highly complex and dynamic and mediate key steps in pathogen adhesion to host, host invasion, and colonization as well as immune evasion. In bacteria, these interactions most often involve specialized virulence factors or effector proteins that specifically target central host proteins. Here, I present a mass spectrometry-based proteomics approach sta

Unstructured Interviews – A Conversational Iceberg

My ongoing work on the lived experiences of young adult migrants is phenomenological research aimed at the process of social resilience and social experiences of young adult migrants. I'm conducting unstructured interviews to learn more about the phenomenon's textural (what was experienced) and structural (how it was experienced) characteristics. In these unstructured interviews, I emphasize the m

Laboratory Experiments on Soil Stabilization to Enhance Strength Parameters for Road Pavement

Clay soils can cause significant distress in road construction due to their low strength. Stabilizing such soil improve with binder agents prior to the geotechnical works can significantly its performance and ensure safety and stability of roads while exploitation. This research envisaged the use of five different binders (lime, energy fly ash, bio fly ash, slag, cement) as an additive stabilizing

Effects of adsorbed molecular ordering to the superconductivity of a two-dimensional atomic layer crystal

The effect of 3,4,9,10-perylenetetracarboxylic dianhydride (PTCDA) adsorption on the physical properties of the two-dimensional (2D) atomic layer superconductor (ALSC) In/Si(111)-(7×3) has been studied by angle-resolved photoelectron spectroscopy, transport measurements, and scanning tunneling microscopy. Hole doping from the adsorbed molecules has been reported to increase the superconducting tra

Direct observation of large-area strain propagation on free-standing nanomembranes

Investigations on epitaxial nanostructures with size of tens of nanometers have been a challenging issue for techniques that present high strain sensitivity but restricted spatial resolution. This is the case of recently developed x-ray nanoprobe techniques. Despite its inherent nondestructive character, submicron x-ray spots have only been successfully applied to the study of individual nanostruc