Amiodarone is a potent antiarrhythmic drug and displays substantial liver toxicity in hu-mans. It has previously been demonstrated that amiodarone and its metabolite (desethylamioda-rone, DEA) can inhibit mitochondrial function, particularly complexes I (CI) and II (CII) of the elec-tron transport system in various animal tissues and cell types. The present study, performed in human peripheral blo

Background: Unhealthy diets, the rise of non-communicable diseases, and the declining health of the planet are highly intertwined, where food production and consumption are major drivers of increases in greenhouse gas emissions, substantial land use, and adverse health such as cancer and mortality. To assess the potential co-benefits from shifting to more sustainable diets, we aimed to investigate

In this contribution, a measurement campaign for high- speed-train (HST) channel is introduced where the down- link signals of in-service Long Time Evolution-Advanced (LTE-A) network deployed along the HST railway between Beijing to Shanghai are acquired. Channel impulse responses (CIRs) are extracted from received signals, and concatenated power delay profiles (CPDPs) are illustrated. According t

In this article, a novel vector network analyzer (VNA)-based ultrawideband (UWB) channel sounder using radio-over-fiber (RoF) techniques is presented. Benefiting from the usage of optical fiber cable, the measurement range and the dynamic range are significantly increased compared with the conventional coaxial-based VNA system. Specifically, using RoF increases the dynamic range to a maximum of 11

In this paper, a recently conducted measurement campaign for unmanned-aerial-vehicle channels is introduced. The downlink signals of an in-service long-time-evolution network, which is deployed in a suburban scenario were acquired. Five horizontal and five vertical flight routes were considered. The channel impulse responses (CIRs) are extracted from the received data by exploiting the cell-specif

Introduction A second peak of inhibitors has been reported in patients with severe hemophilia A (HA) aged >50 years in the United Kingdom. The reason for this suggested breakdown of tolerance in the aging population is unclear, as is the potential impact of regular exposure to the deficient factor by prophylaxis at higher age. No data on hemophilia B (HB) have ever been reported. Aim The ADVANCE W

Remiss över EU-kommissionens meddelande - Mot en modernare och mer europeisk ram för upphovsrätten - JURFAK 2016/3

In today’s knowledge-based global economy, most inventions are made by employed persons through their employers’ research and development activities. However, methods of establishing rights over an employee’s intellectual property assets are relatively uncertain in the absence of international solutions. Given that increasingly more businesses establish entities in different countries and more emp

Anion exchange membranes (AEMs) functionalized with certain alicyclic quaternary ammonium cations show high alkaline stability, which is necessary for use in fuel cells and water electrolyzers. Here, we have prepared and studied a series of poly(fluorene alkylene)s incorporating N,N-dimethylpiperidinium (DMP) and 6-azoniaspiro[5.5]undecane (ASU) cations in spirocyclic and bis-spirocyclic arrangeme

To ensure building construction with low heating demand, efficient use of sustainable energy carriers, and neutrality between heating technologies, Sweden recently introduced weighting factors (WFs) for different energy carriers which are now used in Energy Performance Certificates (EPCs). As EPC ratings are gaining increased influence in Swedish energy policy and regulation, with recent examples

Over the past decade, characteristic mode analysis (CMA) research has grown from a niche topic to a mainstream topic, warranting a tutorial-style special issue to survey the significant progress that has been made in this field. In thisintroductory article (PAPER 1), the focus is on providing the big picture. We start with a simple description of characteristic modes. Next, we examine the trends in

Substitution of IgG in antibody deficiency or application of high-dose intravenous IgG (IVIg) in patients with autoimmunity are well-established treatments. Data on the mode of action of IVIg are, however, controversial and may differ for distinct diseases. In this study, we investigated the impact and molecular mechanism of high-dose IgG treatment in murine autoantibody-induced skin inflammation,

Software evolves continuously. As software evolves, it's code bases require implementations of new features. These new functionalities are sometimes mere extensions of existing functionalities with minor changes. A commonly used method of extending an existing feature into a similar new feature is to copy the existing feature and modify it. This method of extending feature is called "Copy-paste-mo

Phase-noise (PN) estimation and compensation are crucial in millimeter-wave (mmWave) communication systems to achieve high reliability. The PN estimation, however, suffers from high computational complexity due to its fundamental characteristics, such as spectral spreading and fast-varying fluctuations. In this paper, we propose a new framework for low-complexity PN compensation in orthogonal freq

Landscapes play an important role in many areas of biology, in which biological lives are deeply entangled. Here we discuss a form of landscape in evolutionary biology which takes into account (1) initial growth rates, (2) mutation rates, (3) resource consumption by organisms, and (4) cyclic changes in the resources with time. The long-term equilibrium number of surviving organisms as a function o

During eyeblink conditioning, Purkinje cells that control the eyelid learn to respond with a pause in simple spike firing to the conditional stimulus. This conditional pause response (CR) in the Purkinje cell is adaptively timed and drives the overt response. Recent results show that the Purkinje cell CR does not depend on modification of synaptic strength such as long-term depression but on a nov

BACKGROUND: This study aimed to estimate the birth prevalence of children born with isolated or non-isolated clubfoot in Sweden using a national clubfoot register. Secondarily we aimed to describe the clubfoot population with respect to sex, laterality, severity of deformity, comorbidity and geographic location.METHODS: A national register, the Swedish Pediatric Orthopedic Quality register, was us

Single-cell RNAseq is a routinely used method to explore heterogeneity within cell populations. Data from these experiments are often visualized using dimension reduction methods such as UMAP and tSNE, where each cell is projected in two or three dimensional space. Three-dimensional projections can be more informative for larger and complex datasets because they are less prone to merging and flatt