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A multicentre, prospective, randomised controlled trial to assess the safety and effectiveness of cooling as an adjunctive therapy to percutaneous intervention in patients with acute myocardial infarction : The COOL AMI EU Pivotal Trial

Background: Despite primary PCI (PPCI), ST-elevation myocardial infarction (STEMI) can still result in large infarct size (IS). New technology with rapid intravascular cooling showed positive signals for reduction in IS in anterior STEMI. Aims: We investigated the effectiveness and safety of rapid systemic intravascular hypothermia as an adjunct to PPCI in conscious patients, with anterior STEMI,

Relationship between sensorial and physical characteristics of topical creams : A comparative study on effects of excipients

Rising consumer demands for safer, more natural, and sustainable topical products have led to increased interest in finding alternative excipients, while retaining functionality and cosmetic appeal. Particle-stabilized Pickering creams have emerged as possible alternatives to replace traditional surfactant-stabilized creams and are thus one of the focuses in this study. The aim of this paper was t

Getting invasive species on the political agenda : agenda setting and policy formulation in the case of ash dieback in the UK

This study reviews how the issue of ash dieback has been placed on the political agenda in the UK, a country where the disease has affected one of the largest national extents, thus representing a particularly severe case. Comparisons are made between how the scientific community framed the ash dieback threat and the resulting response strategy and how both the media and the British government fra

An overview of cryptographic primitives for possible use in 5G and beyond

This survey overviews the potential use of cryptographic primitives in the fifth-generation mobile communications system (aka 5G) and beyond. It discusses the new security challenges that come with 5G and presents the upcoming security architecture. It shows the use of current cryptographic algorithms and discusses new algorithms or modifications of existing ones, that can be relevant. It also dis

Developmental neurobiology of cerebellar and Basal Ganglia connections

BACKGROUND: The high prevalence of mixed phenotypes of Early Onset Ataxia (EOA) with comorbid dystonia has shifted the pathogenetic concept from the cerebellum towards the interconnected cerebellar motor network. This paper on EOA with comorbid dystonia (EOA-dystonia) explores the conceptual relationship between the motor phenotype and the cortico-basal-ganglia-ponto-cerebellar network.METHODS: In

B lymphocyte specification is preceded by extensive epigenetic priming in multipotent progenitors

B lymphocyte development is dependent on the interplay between the chromatin landscape and lineage-specific transcription factors. It has been suggested that B lineage commitment is associated with major changes in the nuclear chromatin environment, proposing a critical role for lineage-specific transcription factors in the formation of the epigenetic landscape. In this report, we have used chromo

Mapping and characterising the urban agricultural landscape of two intermediate-sized Ghanaian cities

Extending beyond previous research biases towards large cities or analyses based largely on one type of urban agriculture (UA) (such as market gardening, or home gardening), this research aimed to investigate all forms of UA within two intermediate-sized Ghanaian cities (Techiman and Tamale). Where was being farmed? For whom, and why? The paper considers how findings compare to Ghana's larger citi

Development and primary validation of the School Health Assessment Tool for Primary Schools (SHAT-PS)

Background. School health programs need to target all aspects of physical, psychological, and social well-being. Using a slightly modified version of the COSMIN Risk of Bias checklist, we developed and conducted the first validation of the School Health Assessment Tool for Primary Schools (SHAT-PS). Method. The exploratory sequential mixed method was used in this study. In the first phase, scienti

Greening of the Earth and its drivers

Global environmental change is rapidly altering the dynamics of terrestrial vegetation, with consequences for the functioning of the Earth system and provision of ecosystem services. Yet how global vegetation is responding to the changing environment is not well established. Here we use three long-term satellite leaf area index (LAI) records and ten global ecosystem models to investigate four key

The Partisan Impact on Local Government Dissemination of COVID-19 Information : Assessing U.S. County Government Websites

This study explores the relationship between local government dissemination of COVID-19 information and partisanship. The unit of analysis is all official county government websites in the United States. In particular, we investigate if there is a correlation between the overall partisanship of a county and whether a county government's website 1) mentions COVID-19, and 2) provides safety instruct

Three-dimensional reconstruction of human interactions

Understanding 3d human interactions is fundamental for fine grained scene analysis and behavioural modeling. However, most of the existing models focus on analyzing a single person in isolation, and those who process several people focus largely on resolving multi-person data association, rather than inferring interactions. This may lead to incorrect, lifeless 3d estimates, that miss the subtle hu

Changes in diatom productivity and upwelling intensity off Peru since the Last Glacial Maximum : Response to basin-scale atmospheric and oceanic forcing

New records of stable silicon isotope signatures (δ30Si) together with concentrations of biogenic opal and organic carbon from the central (9°S) and northern (5°S) Peruvian margin reveal changes in diatom productivity and nutrient utilization during the past 20,000 years. The findings are based on a new approach using the difference between the δ30Si signatures of small (11–32 µm) and large (>150

Factors controlling plankton community production, export flux, and particulate matter stoichiometry in the coastal upwelling system off Peru

Eastern boundary upwelling systems (EBUS) are among the most productive marine ecosystems on Earth. The production of organic material is fueled by upwelling of nutrient-rich deep waters and high incident light at the sea surface. However, biotic and abiotic factors can modify surface production and related biogeochemical processes. Determining these factors is important because EBUS are considere

Exploring risk factors for developing occupational ill health–departing from an occupational perspective

Background: Sick leave due to stress-related mental ill health increases in society. In occupational therapy, occupational balance is considered important for experiencing health and well-being. Thus, knowledge regarding occupational balance and occupational value constitute essential parts of occupational therapists’ work with people suffering from occupational ill health. Objective: The aim of t

Towards a Time Adaptive Neumann-Neumann Waveform Relaxation Method for Thermal Fluid-Structure Interaction

Our prime motivation is thermal fluid-structure interaction (FSI) where two domains with jumps in the material coefficients are connected through an interface. There exist two main strategies to simulate FSI models: the monolithic approach where a new code is tailored for the coupled equations and the partitioned approach that allows to reuse existing software for each sub-problem. Here we want to

Population of lead isotopes in binary reactions using a Rb 94 radioactive beam

We measured absolute cross sections for neutron transfer channels populated in the Rb94+Pb208 binary reaction. Cross sections have been extracted identifying directly the lead isotopes with the high efficiency MINIBALL γ-ray array coupled to a particle detector combined with a radioactive Rb94 beam delivered at Elab=6.2 MeV/nucleon by the HIE-ISOLDE facility. We observed sizable cross sections in

Changes in numbers of staging and wintering geese in Sweden : 1977/78-2019/20

Regular goose counts made throughout Sweden since 1977/78 show that the total numbers staging and wintering in the country have increased markedly over the decades. October totals were of 51,000 geese in 1977, rising to c. 600,000 in 2018, during which time January totals also increased from 31,000 to 252,000 birds. The greatest change recorded was for the Greylag Goose Anser anser, numbers of whi