Background: Breast cancer arises within specific regions in the human breast referred to as the terminal duct lobular units (TDLUs). These are relatively dynamic structures characterized by sex hormone driven cyclic epithelial turnover. TDLUs consist of unique parenchymal entities embedded within a fibroblast-rich lobular stroma. Here, we established and characterized a new human breast lobular fi

Background: Blood-based biomarkers for Alzheimer's disease (AD) might facilitate identification of participants for clinical trials targeting amyloid beta (Abeta) accumulation, and aid in AD diagnostics. We examined the potential of plasma markers Abeta(1-42/1-40), glial fibrillary acidic protein (GFAP) and neurofilament light (NfL) to identify cerebral amyloidosis and/or disease severity. Methods

Efficient unit propagation for clausal constraints is a core building block of conflict-driven clause learning (CDCL) Boolean satisfiability (SAT) and lazy clause generation constraint programming (CP) solvers. Conflict-driven pseudo-Boolean (PB) solvers extend the CDCL paradigm from clausal constraints to integer linear constraints, also known as (linear) PB constraints. For PB solvers, many diff

As glaciers retreat, their forelands represent “natural laboratories” for the study of primary succession. This review describes how certain arthropods conquer pristine ground and develop food webs before the establishment of vascular plants. Based on soil samples, pitfall traps, fallout and sticky traps, gut content studies, and some unpublished data, we compare early arthropod succession on glac

OBJECTIVE: To compare consultations carried out via video with those performed in person for patients with painful, hard-to-heal ulcers, with a focus on ulcer pain and pain treatment. A further aim was to investigate predictors for pain and pain treatment.METHOD: This was a register-based, quasi-experimental study based on data from the Swedish Registry of Ulcer Treatment (RUT). A total of 100 pat

To utilise carbon dioxide as a resource rather than treating it only as a polluting greenhouse gas is gaining increased attention. Expectations on the future capabilities of technologies that could make utilisation of carbon dioxide possible are currently raised in scientific literature. These are in important ways shaping the development process by defining what is possible and desirable to devel

Regional roles of universities in the Global South have been under-explored, and it is not clear how relevant are concepts originating from the Global North when applied in this context. The paper interrogates the concept of the ‘entrepreneurial university’ and its regional impact and engagement via a case study in Brazil. It is found that, in addition to purely entrepreneurial and economic activi

Purpose: Age-related macular degeneration (AMD) is generally considered a disease of the macula. However, recent studies show peripheral retinal lesions are prevalent in patients with AMD, indicative of a disease process that is more widespread. Full-field electroretinography (ffERG) measures an electrical response, not only from the macula, but from the entire retina. We wanted to study the ffERG

Objective: In previous studies, atherosclerotic vascular events (AVEs) were shown to occur in ~10% of patients with systemic lupus erythematosus (SLE). We undertook this study to investigate the annual occurrence and potential risk factors for AVEs in a multinational, multiethnic inception cohort of patients with SLE. Methods: A large 33-center cohort of SLE patients was followed up yearly between

Background: Swefoot is a Swedish national registry, that covers surgery in the foot and ankle. Surgical treatment of hallux rigidus (HR) vary within and between countries. The aim of this study was to report baseline variables for patients with HR. Methods: We extracted baseline characteristics, surgical procedures and patient-reported data for patients with HR entered in the registry during the p

A technique for enhancing the bandwidth of a broadside tri-modal patch antenna is described. The key idea of the technique is to incorporate a dual-resonance structure into the broadside tri-modal patch geometry. By increasing one edge of the tri-modal patch while decreasing its size at the opposite edge, the resulting structure can be viewed as two super-imposed Y-shaped structures of different r

It is generally found that human capital has had positive effects on industrial development and economic growth, but the relationship between formal education, work practice, industrial development and economic growth, and the relationships between them over time, remains unclear, largely because of a lack of empirical evidence. This note argues that an investigation of the Danish dairy industry c

Breast cancer is a disease of genomic alterations, of which the panorama of somatic mutations and how these relate to subtypes and therapy response is incompletely understood. Within SCAN‐B (ClinicalTrials.gov: NCT02306096), a prospective study elucidating the transcriptomic profiles for thousands of breast cancers, we developed a RNA‐seq pipeline for detection of SNVs/indels and profiled a real‐w

Background. Chaos Engineering is proposed as a practice to verify a system’s resilience under real, operational conditions. It employs fault injection, is originally developed at Netflix, and supported by several tools from there and other sources. Aims. We aim to intro- duce Chaos Engineering at ICA Gruppen AB, a group of companies whose core business is grocery retail, to improve their systems’

ObjectivePediatric anxiety disorders can have a chronic course and are considered gateway disorders to adult psychopathology, but no consistent predictors of long-term outcome have been identified. A single latent symptom dimension that reflects features shared by all mental health disorders, the p factor, is thought to reflect mechanisms that cut across mental disorders. Whether p predicts outcom

The penicillinase thermistor biosensor（Penicillinase sensor） was developed for the rapid monitoring of blood penem antibiotics concentration and rapid identification of extraneous penicillinase in milk on site.However, the wide application of the penicillinase thermistor biosensor was limited due to its intrinsic poor activity to hydrolyze cephem and carbapenem antibiotics.The recently identified

Our aim was to assess the incidence of symptomatic ulnar nerve dislocation and its influence on surgical outcome after primary and revision surgeries in ulnar nerve entrapment at the elbow (ulnar neuropathy at the elbow (UNE) or cubital tunnel syndrome). The influence of pre- or intra-operative ulnar nerve dislocation on postoperative outcome was assessed in 548 surgically treated cases (548 nerve

The recent rise of disinformation and propaganda on social media has attracted strong interest from social scientists. Research on the topic has repeatedly observed ideological asymmetries in disinformation content and reception, wherein conservatives are more likely to view, redistribute, and believe such content. However, preliminary evidence has suggested that race may also play a substantial r

The presence or absence of intermediate-mass black holes (IMBHs) at the centre of Milky Way globular clusters (GCs) is still an open question. This is due to either observational restrictions or limitations in the dynamical modelling method; in this work, we explore the latter. Using a sample of high-end Monte Carlo simulations of GCs, with and without a central IMBH, we study the limitations of s