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Rolando Garcı́a nos enseña que el marco socio-polı́tico determina en alguna medida el marco epistémico e influye igualmente en la estructura social del campo cientı́fico. Una recorrida por los acontecimiento principales, para la civilización europea, desde el presente hasta mediados de siglo XIX nos permiten poner a prueba esta tesis. En lugar de una “historia de las ideas”, una narrativa históric

Decreased spermatogonial numbers in boys with severe haematological diseases

This study examines spermatogonial numbers in testicular samples from 43 prepubertal patients undergoing haematopoietic stem cell transplantation (HSCT). High-dose chemotherapy and/or radiation during HSCT can impact spermatogenesis requiring fertility preservation. Results show that 49% of patients have decreased and 19% severely depleted spermatogonial pool prior to HSCT. Patients with Fanconi a

Dangerous remembering in volatile spaces : Activist memory work in the Iranian context

This article studies the interrelations of memory work and activism in the Iranian context by focusing on the way remembering victims of state violence informs political activism. Due to constant repression, the recurrence of state violence and the criminalisation of oppositional activities and non-conforming lifestyles, the Iranian context is saturated with contentious memories that cannot be bro

The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis

Introduction: Galectin-3 is a pro-fibrotic β-galactoside binding lectin highly expressed in fibrotic liver and implicated in hepatic fibrosis. Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that has high affinity for galectin-3 (human KD = 25 nM; rabbit KD = 12 nM) and high oral bioavailability in rabbits and man. In this study the efficacy of

The Gaia -ESO Survey : No sign of multiple stellar populations in open clusters from their sodium and oxygen abundances

Context. The light element (anti-)correlations shown by globular clusters (GCs) are the main spectroscopic signature of multiple stellar populations. These internal abundance variations provide us with fundamental constraints on the formation mechanism of stellar clusters. Aims. Using Gaia-ESO, the largest and most homogeneous survey of open clusters (OCs), we intend to check whether these stellar

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A correct diagnosis and treatment of fingertip- and nail injuries, commonly seen in the emergency room, is crucial. Insufficient treatment can result in long-term complications, including finger dysfunction and dysaesthesia, nail deformity, infection, or pain. These remaining problems may induce severe impairment of the quality of life of the patient. This review summarises the diagnosis and treat

Alcohol intake and endogenous sex hormones in women : Meta-analysis of cohort studies and Mendelian randomization

Background: The mechanisms underlying alcohol-induced breast carcinogenesis are not fully understood but may involve hormonal changes. Methods: Cross-sectional associations were investigated between self-reported alcohol intake and serum or plasma concentrations of estradiol, estrone, progesterone (in premenopausal women only), testosterone, androstenedione, dehydroepiandrosterone sulfate, and sex

Frequent use of IGHV3-30-3 in SARS-CoV-2 neutralizing antibody responses

The antibody response to SARS-CoV-2 shows biased immunoglobulin heavy chain variable (IGHV) gene usage, allowing definition of genetic signatures for some classes of neutralizing antibodies. We investigated IGHV gene usage frequencies by sorting spike-specific single memory B cells from individuals infected with SARS-CoV-2 early in the pandemic. From two study participants and 703 spike-specific B

Convexity subarachnoid hemorrhage revealed contralateral internal carotid artery dissection due to Eagle syndrome: a case report

BACKGROUND: Atraumatic localized convexity subarachnoid hemorrhage (cSAH) is an uncommon form of nonaneurysmal subarachnoid hemorrhage characterized by bleeding limited to the cerebral convexities. Ipsilateral cSAH can result from a variety of causes, such as internal carotid artery stenosis, obstruction, and dissection, although concomitant contralateral cSAH is exceptionally rare. In this case,

Correlation of adenomyosis features to live birth rates after the first IVF/ICSI treatment, when using the revised Morphological Uterus Sonographic Assessment group definitions

IntroductionData regarding the impact of adenomyosis on the outcomes after in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment are conflicting. Standardized diagnostic criteria are prerequisites for studying a potential association between adenomyosis and IVF/ICSI treatment outcomes. This study aims to examine the cumulative live birth rate (CLBR) after the first IVF/

Cryosurgery of eyelid actinic keratosis and the effect of adrenaline in local anesthetics - temperature mapping using IR thermography

The efficacy of cryosurgery is believed to depend on the thaw time. The presence of adrenaline in local anesthetics affects blood perfusion, and may thus also affect the thaw time. The aim of the present study was to use IR thermography to monitor the tissue temperature during cryosurgery of actinic keratosis, and to assess the effect of adrenaline in local anesthetics.MethodsTwelve patients with

β-galactosidase immobilization on ceramic ultrafiltration membrane for simultaneous lactose hydrolysis and protein separation

Protein and lactose of cheese whey can be separated using ultrafiltration membranes and lactose can be hydrolyzed by β-galactosidase. This study investigated the integration of ultrafiltration and enzymatic hydrolysis for simultaneous protein concentration and lactose hydrolysis. β-galactosidase was immobilized on ceramic membrane via surface activation with gelatin and subsequent enzyme cross-lin

Electrodialysis with sacrificial magnesium anode for nutrient recovery from primary municipal wastewater : Effect on membrane fouling behaviours

The fertilizer industry is experiencing tremendous stress due to its dependence on limited natural resources and high energy consumption, thus great attention has been paid for alternative nitrogen and phosphorus resources. This study employed electrodialysis (ED) with sacrificial magnesium anode to recover nitrogen and phosphorus (towards struvite formation) from primary municipal wastewater and

Urgent endovascular repair of juxtarenal/pararenal aneurysm by off-the-shelf multibranched endograft

Objective: To report outcomes of urgent juxtarenal/pararenal aneurysms (J/P-AAAs) managed by off-the-shelf multibranched thoracoabdominal endografts (Cook, T-branch). Methods: In this observational, multicenter, retrospective study, patients with J/P-AAAs treated by urgent endovascular repair by T-branch in 23 European aortic centers, from 2013 to 2023, were analyzed. Contained J/P-AAAs rupture, p