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OBJECTIVE: To test a simplified blood pressure device called Rastreometro that could be used by the Health Agents.METHODS: The Rastreometro has been developed from an ordinary aneroid sphygmomanometer, in which the numeric display is covered by an adhesive with a red zone, indicating pressures equal or above 140 mmHg and a yellow zone indicating pressures below 140 mmHg. The onset of oscillations

Targeting the hydrophilic regions of recombinant proteins by MS via in-solution buffer-free trypsin digestion

A desalting step using reversed phase chromatography is a common practice prior to mass spectrometry analysis of proteolytic digests in spite of the detrimental exclusion of the hydrophilic peptides. The detection of such peptides is also important for the complete coverage of protein sequences and the analysis of posttranslational modifications as inquired by regulatory agencies for the commercia

Efficient Hardware Implementations of Grain-128AEAD

We implement the Grain-128AEAD stream cipher in hardware, using a 65 nm library. By exploring different optimization techniques, both at RTL level but also during synthesis, we first target high throughput, then low power. We reach over 33 GB/s targeting a high-speed design, at expense of power and area. We also show that, when targeting low power, the design only requires 0.23 $${\upmu }$$W runni

Electronic and molecular structures of the active-site H-cluster in [FeFe]-hydrogenase determined by site-selective X-ray spectroscopy and quantum chemical calculations

The [FeFe]-hydrogenase (HydA1) from green algae is the minimal enzyme for efficient biological hydrogen (H2) production. Its active-site six-iron center (H-cluster) consists of a cubane, [4Fe4S]H, cysteine-linked to a diiron site, [2Fe]H. We utilized the spin-polarization of the iron Kβ X-ray fluorescence emission to perform site-selective X-ray absorption experiments for spectral discrimination o

Bridging-hydride influence on the electronic structure of an [FeFe] hydrogenase active-site model complex revealed by XAES-DFT

Two crystallized [FeFe] hydrogenase model complexes, 1 = (μ-pdt)[Fe(CO)2(PMe3)]2 (pdt = SC1H 2C2H2C3H2S), and their bridging-hydride (Hy) derivative, [1Hy]+ = [(μ-H)(μ-pdt)[Fe(CO)2 (PMe 3)]2]+ (BF4-), were studied by Fe K-edge X-ray absorption and emission spectroscopy, supported by density functional theory. Structural changes in [1Hy]+ compared to 1 involved small bond elongations (

Säkerhetsutbildningar och säkerhetskulturarbete vid forskningsanläggningar med strålningsrisker och många tillfälliga internationella användare – ett fortsättningsprojekt

Det övergripande syftet med detta projekt har varit att ge ett konkret underlag somkan användas som stöd för att utveckla välfungerande kortare säkerhetsutbildningar i säkerhetskritiska verksamheter.Utgångspunkten har varit forskningsanläggningarna MAX IV och EuropeanSpallation Source (ESS) där forskare, dvs användare, från hela världen vistas tillfälligt för att genomföra experiment. Användarna k

Nomenclature and semantic descriptions of ulcerative and inflammatory lesions seen in Crohn’s disease in small bowel capsule endoscopy : An international Delphi consensus statement

Background: In the medical literature, the nomenclature and descriptions (ND) of small bowel (SB) ulcerative and inflammatory (U-I) lesions in capsule endoscopy (CE) are scarce and inconsistent. Inter-observer variability in interpreting these findings remains a major limitation in the assessment of the severity of mucosal lesions, which can impact negatively on clinical care, training and researc

Protecting OpenFlow using Intel SGX

OpenFlow flow tables in Open vSwitch contain valuable information about installed flows, priorities, packet actions and routing policies. Their importance is emphasised when collocated tenants compete for the limited entries available to install flow rules. OpenFlow flow tables are a security asset that requires confidentiality and integrity guarantees. However, commodity software switch implement

International classification of abdominal wall planes (ICAP) to describe mesh insertion for ventral hernia repair

Background: Nomenclature for mesh insertion during ventral hernia repair is inconsistent and confusing. Several terms, including ‘inlay’, ‘sublay’ and ‘underlay’, can refer to the same anatomical planes in the indexed literature. This frustrates comparisons of surgical practice and may invalidate meta-analyses comparing surgical outcomes. The aim of this study was to establish an international cla

Ocean acidification increases iodine accumulation in kelp-based coastal food webs

Kelp are main iodine accumulators in the ocean, and their growth and photosynthesis are likely to benefit from elevated seawater CO2 levels due to ocean acidification. However, there are currently no data on the effects of ocean acidification on iodine metabolism in kelp. As key primary producers in coastal ecosystems worldwide, any change in their iodine metabolism caused by climate change will p

Self-Service Business Analytics and the Path to Insights : Integrating Resources for Generating Insights

The nature of today’s business demands that Business Analytics (BA) extends to an operational level to better support employees in their decision-making. This is noticeable from the constant requests for new reports and changes in old ones at different employee levels. As a result, BA specialists or other power-users in functional departments are “bombarded” by these requests, and it becomes more

Visible light induction of an electron paramagnetic resonance split signal in photosystem II in the S 2 state reveals the importance of charges in the oxygen-evolving center during catalysis : A unifying model

Cryogenic illumination of Photosystem II (PSII) can lead to the trapping of the metastable radical Y Z •, the radical form of the redox-active tyrosine residue D1-Tyr161 (known as Y Z). Magnetic interaction between this radical and the CaMn 4 cluster of PSII gives rise to so-called split electron paramagnetic resonance (EPR) signals with characteristics that are dependent on the S state. We report

The formation of the split EPR signal from the S3 state of Photosystem II does not involve primary charge separation

Metalloradical EPR signals have been found in intact Photosystem II at cryogenic temperatures. They reflect the light-driven formation of the tyrosine Z radical (YZ) in magnetic interaction with the CaMn4 cluster in a particular S state. These so-called split EPR signals, induced at cryogenic temperatures, provide means to study the otherwise transient YZ and to probe the S states with EPR spectro

Split EPR signals from photosystem II are modified by methanol, reflecting S state-dependent binding and alterations in the magnetic coupling in the CaMn4 cluster

Methanol binds to the CaMn4 cluster in photosystem II (PSII). Here we report the methanol dependence of the split EPR signals originating from the magnetic interaction between the CaMn4 cluster and the Y Z· radical in PSII which are induced by illumination at 5 K. We found that the magnitudes of the "split S1" and "split S3" signals induced in the S1 and S 3 states of PSII centers, respectively, a