Objective: A liquid mepolizumab formulation in a single-use prefilled syringe (PFS) is under development. We evaluated the usability of mepolizumab self-injected via PFS by patients with severe eosinophilic asthma (SEA), or their caregivers, in clinic and at home. Methods: This open-label, single-arm, Phase IIIa study included patients with SEA, aged ≥12 years, and receiving mepolizumab (100 mg su

The local magnetic field inside and around an object in a magnetic resonance imaging unit depends on the magnetic susceptibility of the object being magnetized, in combination with its geometry/orientation. Magnetic susceptibility can thus be exploited as a source of tissue contrast, and susceptibility imaging may also become a useful tool in contrast agent quantification and for assessment of ven

Background: In clinical research information can be retrieved through various sources. The aim is to evaluate the agreement between answers in patient questionnaires and clinical reports in a study of patients after radical prostatectomy and patient characteristics associated with agreement between these two data sources. Methods: In the prospective non-randomized longitudinal trial LAParoscopic P

Contrary to common perception, we show that the current Higgs data does not eliminate the possibility of a sequential fourth generation that get their masses through the same Higgs mechanism as the first three generations. The inability to fix the sign of the bottom-quark Yukawa coupling from the available data plays a crucial role in accommodating a chiral fourth generation which is consistent wi

Vilka nya konsumtionsformat växer fram inom den kollaborativa ekonomin och hur förhåller dessa sig till en normativ konsumtionskultur? Bidraget diskuterar tre olika exempel på hur olika former för delande - med lånepraktiker i centrum - kan organiseras och vilka normer och värderinhgar som är knutna till dessa.

The authors present calculations of the two-photon one-electron ionisation of the 5p shell of xenon including non-linear response. Screening effects are described within the random-phase approximation (RPA). The authors use both a local-density approximation (LDA) and a Hartree-Fock average basis set. They describe a large energy region from the two-photon ionisation threshold to above the one-pho

We review the main experimental results obtained in the multielectron multiphoton ionization of rare gases. Multiple ionization is interpretated as a sequential process. We study the influence of many‐electron effects in multiphoton ionization within the framework of the random phase approximation. This is applied to a calculation of the two‐photon ionization cross section of xenon. Finally, the r

We study the influence of many-electron effects in multiphoton ionization within the framework of diagrammatic many-body perturbation theory. We renormalize the electron-dipole coupling by summing to infinite order both many-electron interactions using the random-phase approximation and higher-order intensity terms. We introduce an effective intensity, which takes into account the screening of the

During lipolysis of chylomicron triacylglycerol by lipoprotein lipase, arachidonic acid (AA) esters are hydrolyzed at a slower rate than the predominant 16-18 carbon fatty acid esters. The further metabolism of the AA that is hereby enriched in the chylomicron remnant acylglycerols has not been investigated. In the present study, we examined the low density lipoprotein (LDL) dependent and independDuring lipolysis of chylomicron triacylglycerol by lipoprotein lipase, arachidonic acid (AA) esters are hydrolyzed at a slower rate than the predominant 16-18 carbon fatty acid esters. The further metabolism of the AA that is hereby enriched in the chylomicron remnant acylglycerols has not been investigated. In the present study, we examined the low density lipoprotein (LDL) dependent and independ

Innate immune responses are rapid, dynamic and highly regulated to avoid overt reactions. This regulation is executed by innate immune tolerance mechanisms that remain obscure. Wnt5a is a signalling protein mainly involved in developmental processes and cancer. The effect of Wnt5a on inflammatory myeloid cells is controversial. Here, we combine primary cell cultures, in vitro binding studies, mass

The electronic structure of eleven crystalline nickel oxides was investigated by band theory - CNDO method. Both the band and local properties of the electronic structure were calculated and were used for the description of chemical bonding in Ni(II) (NiO, Li2NiO2, Na2NiO2, K2NiO2, BaNiO2, La2NiO4), Ni(III) (LiNiO2, NaNiO2, LaNiO3) and Ni(IV) (BaNiO3) compounds.

In a truly model-independent approach, we reexamine a minimal extension of the Standard Model (SM) through the introduction of an additional U(1) symmetry leading to a new neutral gauge boson (Z′), allowing its kinetic mixing with the hypercharge gauge boson. An SM neutral scalar is used to spontaneously break this extra symmetry, leading to the mass of the Z′. Except for three right-handed neutri

The stress driven growth of an expanding precipitate at a crack tip is studied. The material is assumed to be linearly elastic, and the expansion is considered to be isotropic or transversely isotropic. The extent of the precipitate is expected to be small as compared with the crack length and distance to boundaries. The problem has only a single length scale given by the squared ratio of the stre

Worldwide, but subject to substantial variations across countries, housing adaptations and home modifications constitute important and common interventions in occupational therapy practice. Starting out from the notion that occupational performance is the outcome of person–environment–occupation (P–E–O) transactions, such interventions are applicable with all kinds of clients with occupational per