OBJECTIVE: To describe and examine potential predictors of changes in pain and disability in patients with shoulder pain who have completed 3 months of digitally delivered treatment comprising exercise and patient education.DESIGN: Retrospective cohort study (clinicaltrials.org Nr: NCT05402514).SUBJECTS: Patients with shoulder pain who completed treatment (n = 682).METHODS: Primary outcome was cha

Liver-generated plasma apolipoprotein E (apoE) does not enter the brain but nonetheless correlates with Alzheimer's disease (AD) risk and AD biomarker levels. Carriers of APOEε4, the strongest genetic AD risk factor, exhibit lower plasma apoE and altered brain integrity already at mid-life versus non-APOEε4 carriers. Whether altered plasma liver-derived apoE or specifically an APOEε4 liver phenoty

Mice harbor ∼2800 intact copies of the retrotransposon Long Interspersed Element 1 (L1). The in vivo retrotransposition capacity of an L1 copy is defined by both its sequence integrity and epigenetic status, including DNA methylation of the monomeric units constituting young mouse L1 promoters. Locus-specific L1 methylation dynamics during development may therefore elucidate and explain spatiotemp

Induced pluripotent stem cells (iPSCs) can in principle differentiate into any cell of the body, and have revolutionized biomedical research and regenerative medicine. Unlike their human counterparts, mouse iPSCs (miPSCs) are reported to silence transposable elements and prevent transposable element-mediated mutagenesis. Here we apply short-read or Oxford Nanopore Technologies long-read genome seq

In Verbal Aspect in Synoptic Parallels Wally Cirafesi answers the question of why the Synoptic Gospels at times employ different tense-forms to communicate the same action. The problem has typically been explained from the perspective of redaction criticism and temporal Aktionsart approaches to the Greek verb. Cirafesi challenges these approaches by reframing the discussion in terms of recent adva

Retrotransposons are mobile DNA sequences duplicated via transcription and reverse transcription of an RNA intermediate. Cis-regulatory elements encoded by retrotransposons can also promote the transcription of adjacent genes. Somatic LINE-1 (L1) retrotransposon insertions have been detected in mammalian neurons. It is, however, unclear whether L1 sequences are mobile in only some neuronal lineage

Water management in San Pedro Mártir faces critical challenges due to gender dynamics that limit women's effective participation in water governance. Although they manage water at the domestic and community level, their voice in decision-making is minimal, perpetuating inequalities and compromising the sustainability of water management practices in a context of growing scarcity. The methodolo

Socio-environmental crisis are also crisis of imagination. In the city of Taranto, the heavy industry has had devastating socio-environmental effects, and the dominant narrative still considers environmental and social sustainability as a double bind. Consequently, to this date there is no sign that anticipate a solution to the socio-environmental crisis. By means of 3 horizons framework, this wor

This article examines the dynamics of matter and signifiers in Zola’s two novels Nana (1880) and Money (1891). Though Zola’s novels are often read with a focus on capital and economics workings, the context of marginalist economics contemporaneous to Zola is only vaguely described. In drawing upon Jean-Joseph Goux’s work on marginalism and Zola, this topic is addressed, and the article discusses d

This article presents readings of three French novels from the nineteenth century, namely Balzac's La Peau de chagrin, Huysmans' À rebours and Octave Mirbeau's Le Jardin des supplices. It examines issues of representation and meaning in relation to debt narratives and the use of bodies as a motif in relation to debt, and it argues that, in these novels, literary language and monetary representatio

Bakgrund: Denna magisteruppsats syftar till att svara på vilka likheter och skillnader som finns mellan det logopediska omhändertagandet i Sverige och andra länder av trakeostomerade och laryngektomerade patienter med dysfagi. Den syftar också till att svara på vilka lärdomar logopeder i Sverige kan dra om det logopediska omhändertagandet av dessa patientgrupper i andra länder. Metod: För att besvBackground: This thesis aims to answer what similarities and differences exist between the SLP care of tracheostomized and laryngectomized patients with dysphagia, in Sweden and other countries. It aims to answer what SLPs in Sweden can learn about SLP care in these patient groups in other countries. Method: To answer the questions the interview material was transcribed and analyzed with text cond