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Acute systemic LPS-exposure impairs perivascular CSF distribution in mice

BACKGROUND: The exchange of cerebrospinal (CSF) and interstitial fluid is believed to be vital for waste clearance in the brain. The sleep-dependent glymphatic system, which is comprised of perivascular flow of CSF and is largely dependent on arterial pulsatility and astrocytic aquaporin-4 (AQP4) expression, facilitates much of this brain clearance. During the last decade, several observations hav

Analysis and design of recovery behaviour of autonomous-vehicle avoidance manoeuvres

Autonomous vehicles allow utilisation of new optimal driving approaches that increase vehicle safety by combining optimal all-wheel braking and steering even at the limit of tyre–road friction. One important case is an avoidance manoeuvre that, in previous research, for example, has been approached by different optimisation formulations. An avoidance manoeuvre is typically composed of an evasive p

Application of lean methods into design process of large power transformers

The paper presents application of lean engineering methods at design process re-engineering. Lean principles are harder to implement in an one-of-a-kind production environment rather than in an environment of a serial production, where there are almost no changes during production process. There are considerable differences in value-added activities that characterize lean production on one hand an

Exact expressions for numerical evaluation of high order modes of vibration in uniform Euler-Bernoulli beams

In the literature, expressions can be found for the mode shape functions of uniform Euler-Bernoulli beams. However, these expressions permit the evaluation of only the first 12 modes or so due to numerical issues associated with the evaluation of near field waves that increase exponentially with frequency. To overcome this problem, approximate expressions have been developed that avoid the evaluat

Performing building vibration assessments by acoustic measurements

This article presents an innovative application of the frequency domain decomposition method based on an acoustic and vibration response. Frequency domain decomposition method has been frequently used for operational modal analysis testing in the last decade to identify modal parameters for in-situ case studies. For these studies, the outputs of the vibration response through accelerometers have b

A new approach to detection of antigen-antibody complexes by microcalorimetric measurements of heat production in blood cells

Using batch microcalorimeters of the thermopile conduction type, heat production was measured in human blood in the presence of defined antigens and their specific antibodies. A large increase in heat production, reflecting increased metabolic activity in the blood cells, was found when antigens and specific antisera at certain antigen-antibody proportions were mixed with the blood. The reproducib

Application of lean methods into aircraft maintenance processes

Aircraft Maintenance and Repair Organizations (MRO) have to be competitive and attractive for the existing and new customers. Aircraft ground time at the MRO has to be as short as possible as well as cost efficient without reducing the quality of the accomplished work. Application of lean methods into aircraft maintenance processes means continuous improvement process and elimination of non-value-

Does risk communication really decrease cooperation in climate change mitigation?

Effective communication of risks involved in the climate change discussion is crucial and despite ambitious protection policies, the possibility of irreversible consequences actually occurring can only be diminished but never ruled out completely. We present a laboratory experiment that studies how residual risk of failure of climate change policies affects willingness to contribute to such polici

Solving Galbrun’s Equation with a Discontinuous galerkin Finite Element Method

Over many years, scientists and engineers have developed a broad variety of mathematical formulations to investigate the propagation and interactions with flow of flow-induced noise in early-stage of product design and development. Beside established theories such as the linearized Euler equations (LEE), the linearized Navier–Stokes equations (LNSE) and the acoustic perturbation equations (APE) wh

Traffic noise sources in cutting dips adjacent to screens

The use of a single vertical screen to obstruct the propagation of noise from source to receiver over hard and soft flat ground is well known. However, In addition to considerations of acoustical efficiency, the design of road traffic noise barriers depends on many other factors. Site conditions, planning restraints and visual considerations will affect the final selected design, as will engineeri

Decreased responsiveness to immune complexes of granulocytes from patients with acute leukemia in remission demonstrated by microcalorimetry

Functional activity of granulocytes from healthy individuals and from patients with acute leukemia in remission was studied. The increase of heat production rate (metabolic activity) after stimulation of the blood cells with in vitro formed immune complexes was measured by microcalorimeters of heat conduction type. It was demonstrated that increased heat production rate after exposure to immune co