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In search of the best method to predict acute coronary syndrome using only the electrocardiogram from the emergency department.

INTRODUCTION: The aim of this study was to compare different methods to predict acute coronary syndrome (ACS) using only data from a single electrocardiogram (ECG) in the emergency department (ED). METHOD: We compared the ACS prediction abilities of classical ECG criteria, human expert ECG interpretation, a logistic regression model and an artificial neural network ensemble (ANN). The ED ECG and d

Fibre type proportion and fibre size in trapezius muscle biopsies from cleaners with and without myalgia and its correlation with ragged red fibres, cytochrome-c-oxidase-negative fibres, biomechanical output, perception of fatigue, and surface electromyography during repetitive forward flexions

In the literature enlarged/increased cross-sectional area (CSA) of type I muscle fibres has been reported as a morphological mark of work-related localised myalgia in the descending part of the trapezius muscle of women. These studies did not use enough subjects or lacked an adequate control group. The recording of surface electromyograms (EMG) is central to the research field of work-related myal

{alpha}1-antitrypsin Inhibits the Activity of the Matriptase Catalytic Domain in vitro.

Matriptase is a type II transmembrane protease which is characterized by an N-terminal transmembrane and multiple extracellular domains, in addition to the conserved extracellular serine protease catalytic domain. The expression pattern of matriptase suggests that this protease may play broad roles in the biology of surface lining epithelial cells. In this study we report that alpha1-antitrypsin (

Contrasting Soil pH Effects on Fungal and Bacterial Growth Suggest Functional Redundancy in Carbon Mineralization

The influence of pH on the relative importance of the two principal decomposer groups in soil, fungi and bacteria, was investigated along a continuous soil pH gradient at Hoosfield acid strip at Rothamsted Research in the United Kingdom. This experimental location provides a uniform pH gradient, ranging from pH 8.3 to 4.0, within 180 m in a silty loam soil on which barley has been continuously gro

Detailed models of the binary pulsars J1141-6545 and B2303+46

We have modelled the formation of the eccentric double-degenerate binaries J1141-6545 and B2303+46 using the Henyey-type full stellar evolution code STARS and the population synthesis code BSE. We find that the outcome depends strongly on the common envelope (CE) evolution efficiency parameter alpha(CE) and show that both systems can be modelled with a single value of alpha(CE). The final orbit of

Closed-loop Combustion Control of Homogeneous Charge Compression Ignition (HCCI) Engine Dynamics

Homogeneous charge compression ignition (HCCI) is a hybrid of the sparkignition and compression ignition engine concepts. As in a sparkignition engine, a homogeneous fuel-air mixture is created in theinlet system. During the compression stroke the temperature of themixture increases and reaches the point of auto ignition, just as in acompression ignition engine (or Diesel). One challenge with HCCI

Impact of trait anxiety and social conformity on responses to experimental chemical challenge

The study examined the impact of trait anxiety and social conformity on ratings and test performance during controlled solvent challenge. Healthy women (n = 20) and men (n = 18) were exposed to increasing levels of toluene and n-butyl acetate in a challenge chamber, during which they repeatedly rated smell intensity and annoyance, and completed neurobehavioral tests. Trait anxiety was measured by

Isothermal Calorimetry for Biological Applications in Food Science and Technology

All physical, chemical and biological processes produce heat and isothermal calorimetry is a general measurement technique to study all kinds of processes by the heat they produce. This paper gives several examples of studies of biological processes in the food area using isothermal calorimetry. It is for example shown how different unit operations influence respiration of vegetable tissue, how th

Population viability analysis on domestic horse breeds (Equus caballus)

In this study, we performed a population viability analysis on 3 domestic horse breeds (Equus caballus) of Danish origin, namely, the Frederiksborg, the Knabstrupper, and the Jutland breeds. Because of their small population sizes, these breeds are considered endangered. The Vortex software simulation package was used for the population viability analysis. First, we investigated the future viabili

Endothelial expression of MHC class II molecules in autoimmune disease

Major histocompatibility complex (MHC) class II molecules are up-regulated on endothelial cells in human allografts, and are thought to be involved in graft rejection. The MFIC class 11 subtypes HLA-DR, DQ and DP regulate T cell dependent immune responses, and aberrant expression could be important in autoimmunity. Increased endothelial MHC class II expression has been demonstrated in several auto

Exposure-response relationships in the formation of specific antibodies to hexahydrophthalic anhydride in exposed workers

OBJECTIVES--Exposure-response relationships in the formation of specific antibodies to hexahydrophthalic anhydride (HHPA) was studied in exposed workers. METHODS--The relation between exposure to HHPA and the levels of specific immunoglobin E [(radioallergosorbent test (RAST)] and immunoglobin G (enzyme-linked immunosorbent assay) antibodies was investigated in a cross-sectional study on 95 worker

The role of fungi in weathering

No rock at the Earth's surface escapes weathering. This process is the primary source of all the essential elements for organisms, except nitrogen and carbon. Since the onset of terrestrial life, weathering has been accelerated under the influence of biota. The study of biological weathering started at the end of the 19th century. Although the role of bacteria (Eubacteria, Archaea) has attracted a

Mid-Holocene Littorina Sea transgressions based on stratigraphic studies in coastal lakes of NW Russia

The mid-Holocene Littorina Sea transgression has been studied in sediment cores from four coastal lakes in NW Russia. The basins are situated in the same drainage system at elevations from 6.9 to 9.2 m a.s.l. Complementary parameters have been applied to identify water-level changes. Chronological models are based on AMS radiocarbon dating of bulk sediments but also wood remains and moss sedge pea

Multicolor COBRA-FISH analysis of chronic myeloid leukemia reveals novel cryptic balanced translocations during disease progression.

During the initial indolent chronic phase of chronic myeloid leukemia (CML), the t(9;22)(q34;q11), resulting in the Philadelphia chromosome (Ph), is usually the sole cytogenetic anomaly, but as the disease progresses into the accelerated phase (AP), and eventually into aggressive blast crisis (BC), secondary aberrations, mainly unbalanced changes such as +8, i(17q), and +Ph, are frequent. To date,

Pathogen infection and selection on fertilization success in Cucumis sativus

We investigated whether resistant pollen genotypes can be selected for when the maternal plants are infected and whether infection can result to changes in the pistil nutrient level influencing reproductive outcome. Both resistance and susceptibility come with costs that may affect pre- and post-fertilization reproductive functions. We performed the study by crossing zucchini yellow mosaic virus r

Effects of ethanol intake on lipoprotein lipase activity in adipose tissue of fasting subjects

Ethanol (ca. 1 g/kg body weight) was given alone or together with glucose or lipid (mixed triglycerides) perorally to young, fasting subjects. The changes with time (0-6 hr) of lipoprotein lipase activity (LLA) in adipose tissue, plasma glycerol, triglyceride, insulin, blood glucose, and alcohol concentrations were followed. A maximal mean blood alcohol concentration of 0.09% (w/v) was obtained 1

Identification of p53 as a strong predictor of survival for patients with malignant peripheral nerve sheath tumors

The purpose of this study was to identify new prognostic biomarkers with clinical impact in malignant peripheral nerve sheath tumor (MPNST), a highly aggressive malignancy for which no consensus therapy exists besides surgery. We have used tissue microarrays (TMAs) to assess in situ expression of 14 cell-cycle-regulating proteins in 64 well-characterized MPNST patients: 36 sporadic and 28 with neu