Large-scale human exome sequencing can identify rare protein-coding variants with a large impact on complex traits such as body adiposity. We sequenced the exomes of 645,626 individuals from the United Kingdom, the United States, and Mexico and estimated associations of rare coding variants with body mass index (BMI). We identified 16 genes with an exome-wide significant association with BMI, incl

The realization of unique scientific phenomena in two-dimensional nanomaterials (2DNMs) has led to their applications in several electronic fields; making it imperative to understand the conduction mechanism of charge carriers in such systems. Though several studies have been conducted on 2DNMs with pristine crystallinity, the inevitable presence of defects in the crystals requires careful conside

AbstractModern radiotherapy aims to treat the decease while minimizing the radiation dose to the adjacent normal tissue, to minimize acute and late effects of the treatment. The foremost technological approaches have been intensity modulated radiotherapy (IMRT) and intensity modulated proton therapy (IMPT) in combination with image guided radiotherapy (IGRT). IMRT and IMPT is characterized by a moModern radiotherapy aims to treat the decease while minimizing the radiation dose to the adjacent normal tissue, to minimize acute and late effects of the treatment. The foremost technological approaches have been intensity modulated radiotherapy (IMRT) and intensity modulated proton therapy (IMPT) in combination with image guided radiotherapy (IGRT). IMRT and IMPT is characterized by a more confo

The pericardial cavity, sinuses, and recesses are frequently depicted on Computed Tomography (CT) and Magnetic Resonance (MR). We here review the normal human pericardial structures as provided by MR imaging of young, healthy subject and CT scans acquired after iatrogenic coronary dissection. We compared such radiological information with cadaveric axial and sagittal sections of the human body pro

Automation is a collection of a whole set of theories and methods to make a system work automatically as intended, in our case the urban water supply system. A critical feature of automation is the feedback principle: a sensor is measuring a certain variable, e.g. a concentration; a computer tests that the measurement is valid; a computer algorithm calculates and decides what should be corrected;

In this work, we analyse the all-orders resummation structure of the momentum sharing fraction, zg, opening angle, θg, and relative transverse momentum, kt,g, of the splitting tagged by the Dynamical Grooming procedure in hadronic collisions. We demonstrate that their resummation does non-exponentiate and it is free of clustering logarithms. Then, we analytically compute the probability distributi

Latin America is often considered the world’s most unequal region. This inequality is not limited to socioeconomic differences; it is also seen through discrepancies in access to nature, land, and natural resources. The Covid-19 pandemic has intensified existing vulnerabilities felt by communities, especially susceptible to environmental degradation through furthering their socioeconomic disadvant

Double-chain amphiphilic compounds, including surfactants and lipids, have broad significance in applications like personal care and biology. A study on the phase structures and their transitions focusing on dioctadecyldimethylammonium chloride (DODAC), used inter alia in hair conditioners, is presented. The phase behaviour is dominated by two bilayer lamellar phases, Lβ and Lα, with “solid” and “

Recent political, legal and social shifts in relation to the rights and recognition of lesbian, gay, bisexual, transgender and queer (LGBTQ) people in Vietnam have facilitated increasing openness about the non-heteronormative preferences of young adults. However, established societal and familial norms related to the importance of heteronormative marriage and family values continue to impact signi

Despite advances in treatment over the last decades, subarachnoid hemorrhage (SAH) continues to carry a high burden of morbidity and mortality, largely afflicting a fairly young population. Several animal models of SAH have been developed to investigate the pathophysiological mechanisms behind SAH and to test pharmacological interventions. The pre-chiasmatic, single injection model in the rat pres

Long-distance migration has evolved repeatedly in animals and covers substantial distances across the globe. The overall speed of migration in birds is determined by fueling rate at stopover, flight speed, power consumption during flight, and wind support. The highest speeds (500 km/day) have been predicted in small birds with a fly-and-forage strategy, such as swallows and swifts. Here, we use GL

Museomics is a valuable approach that utilizes the diverse biobanks that are natural history museums. The ability to sequence genomes from old specimens has expanded not only the variety of interesting taxa available to study but also the scope of questions that can be investigated in order to further knowledge about biodiversity. Here, we present whole genome sequencing results from the enigmatic

A g-C3N4/CdSe quantum dot/[Fe2S2(CO)6] composite has been successfully constructed. The structure and chemical composition of the composite were investigated via, inter alia, transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS). The ability of the assembly to act as a photocatalyst for proton reduction to form hydrogen g

The Pleistocene-Holocene transition brought turbulent times to human societies confronted by rapid climatic fluctuations, shifts inbiogeographic zones and the flooding of continental shelves. While the disappearance of Doggerland’s inhabited landscapes underthe grey waters of the North Sea marks the culmination of these changes for European Archaeologists, our aim is this paper is todraw parallels

We extend the notion of quasibounded harmonic functions to the plurisubharmonic setting. As an application, using the theory of Jensen measures, we show that certain generalized Dirichlet problems with unbounded boundary data admit unique solutions, and that these solutions are continuous outside a pluripolar set.

Major volcanic eruptions are one of the most devastating and unpredictable events for all societies past and present. Althoughmajor progress has been made by archaeologists in understanding volcanic impacts on past societies, almost all this work hasfocused on urban or settled agricultural societies. In contrast, there is a major gap in knowledge about how forager communitieswere able to respond a

Background: Kangaroo mother care including skin-to-skin care aims to overcome the negative effects of separating parents and infants and to increase the quality of care for infants and parents in need of neonatal care. In most cases where inter-hospital transport is needed, the infant is placed in a transport incubator, which increases the risk of separation due to ambulance service restrictions t

Stress factors such as climate change and drought may switch the role of temperate peatlands from carbon dioxide (CO2) sinks to sources, leading to positive feedback to global climate change. Water level management has been regarded as an important climate change mitigation strategy as it can sustain the natural net CO2 sink function of a peatland. Little is known about how resilient peatlands are