The canonical Wnt signaling can be silenced either through β-catenin-mediated ubiquitination and degradation or through phosphorylation of Tcf and Lef by nemo-like kinase (NLK). In the present study, we generated NLK deficient animals and found that these mice become cyanotic shortly before death because of lung maturation defects. NLK-/- lungs exhibited smaller and compressed alveoli and the mese

This paper explores the meaning and potential impact of a number of street artworks that in different ways address and problematise how human beings relate to the biotic community – that is to say a community founded on biocentrism that includes as its members “soils, waters, plants, and animals, or collectively: the land” (Leopold, 1949/1968, p. 203.).The paper argues that while, for example, inf

INTRODUCTION: Not only repolarization, but also depolarization ECG indexes reflect the progression of ischemic injury. The aim was to assess the QRS duration and morphology dynamics during the prolonged coronary occlusion and their association with the myocardial area at risk (MaR) and final infarct size (IS).METHODS: In pigs, myocardial infarction was induced by inflation of an angioplasty balloo

Huntington's Disease (HD) is an inherited neurodegenerative disease caused by a polyglutamine expansion in the huntingtin protein. The YAC128 mouse model of HD expresses the full-length human huntingtin protein with 128 CAG repeats and replicates the phenotype and neurodegeneration that occur in HD. Several studies have implicated a role for neuroinflammation in HD pathogenesis. Studies on presymp

The purpose of this work is to develop and implement a simple and robust preservation technology that can enhance food and economic security and thereby improve the lives of people in developing countries. The technique under development is termed “solar assisted pervaporation (SAP)”. It is a sustainable technology whereby fruit juices or purées are concentrated using reusable pouches made of “bre

Den 15 mars hoppade Felix Baumgartner från 22 km höjd. Detta var ett steg på vägen att slå det tidigare höjdrekordet: Joe Kittinger hoppade 1960 hoppade från en heliumballong på mer än 3 mils höjd, som en del av USAs rymdprogam. Att man kan komma så högt med en heliumballong, och sedan falla mot jorden, medan temperaturen varierar och luftens densitet och luftmotståndet hela tiden ökar, inbjuder t

Hopp från ballonger på flera mils höjd inbjuder till fysiksamtal.

Due to the increasing power requirement and the limited available space in vehicles, placing the heat exchanger at the roof or the underbody of vehicles might increase the possibility to handle the cooling requirement. A new configuration of the heat exchanger has to be developed to accommodate with the position change. In this paper, a countercurrent heat exchanger is developed for position on th

The manifesto of a new philosophy of technology

Many studies assume a respiratory quotient (RQ = molar ratio of CO2 produced to O2 consumed) close to 1 when calculating bacterioplankton respiration. However, evidence suggests that RQ depends on the chemical composition of the respired substrate pool that may be altered by photo-chemical production of oxygen-rich substrates, resulting in elevated RQs. Here we conducted a novel study of the impac

Specialiseringstjänstgöringen i Sverige har under de senaste åren genomgått genomgripande förändringar och ställer handledare av ST-läkare inför nya förutsättningar och utmaningar. Denna bok är skriven för handledare av läkare under utbildning och för alla som är intresserade av sådan handledning. Författarna utgår från de nya föreskrifterna och målbeskrivningarna och visar hur handledningen kan

Background: Ischemic stroke (IS) is a leading cause of death and disability worldwide. As genetic heritability for IS is estimated at about 35%-40%, the identification of genetic variants associated with IS risk is of great importance. The main objective of this study was to carry out a meta-analysis for polymorphisms in CRP, EPHX2, FGA, and NOTCH3 genes and the risk for IS. Methods: Literature se

Contactin genes CNTN5 and CNTN6 code for neuronal cell adhesion molecules that promote neurite outgrowth in sensory-motor neuronal pathways. Mutations of CNTN5 and CNTN6 have previously been reported in individuals with autism spectrum disorders (ASDs), but very little is known on their prevalence and clinical impact. In this study, we identified CNTN5 and CNTN6 deleteriousvariants in individuals

OBJECTIVE: To compare the clinical presentation of children with anorexia nervosa (AN group) with that of children with low-weight food intake disorder without weight and shape-related psychopathology (non-AN group). METHOD: Medical and psychiatric data were obtained from the case records of a consecutive series of 102 children with an eating disorder and a pronounced low weight who were below t

State-ownership has often been discussed as one of the major causes of poor industrial energy efficiency performance. This paper utilizes long-run historical data on the energy and material use in one specific industrial sector – the iron and steel production – in countries with both central-planning and market-based system, with a particular focus on former Czechoslovakia paralleled with the deve

Ischemic stroke is caused by occlusion of a cerebral artery, which gives rise to focal ischemia with irreversible injury in a core region and partially reversible damage in the surrounding penumbra zone. Stroke leads to neural death and consequently neurological impairments. Therapeutic intervention of stroke comprises thrombolysis and thrombectomy by chemical or surgical means, respectively. If d